DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and Pcsk5

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	XP_038965620.1	Gene:	Pcsk5 / 116548	RGDID:	620326	Length:	1878	Species:	Rattus norvegicus

Alignment Length:	1274	Identity:	427/1274 - (33%)
Similarity:	562/1274 - (44%)	Gaps:	307/1274 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSL--SPATHHQTRLDD 291
            ||:.|||.|..| ...||.:|..:||:|:|:|  ..|:|||.|.:..|||:  |..||  :.:..
  Rat    37 YTNHWAVKIAGG-FAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTH--SFISM 98

  Fly   292 DDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGL-----DM 351
            :.:|.|.:||..|.|:|||:       ..|||.|..    |||.|||.|||::.....     ||
  Rat    99 EPKVEWIQQQVVKKRTKRDY-------DLSRAQSTY----FNDPKWPSMWYMHCSDNTHPCQSDM 152

  Fly   352 NVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTR 416
            |:..|||.|.|||.:||||||||:|..|||:..|||..||.|||.:|.||||.||.::.|:||||
  Rat   153 NIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTR 217

  Fly   417 CAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKT 481
            ||||||||||||.|.||||:.|.:||||||||||||.|||:|:|.||||:.||||||||||||||
  Rat   218 CAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKT 282

  Fly   482 VDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVP 546
            ||||..|..:||..|...||.|.||:|:||||||||.:|:|:||||||||:|:||||..|.|..|
  Rat   283 VDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKP 347

  Fly   547 WYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRD 611
            ||.|:||||||||||||...:|:::||||...||.:|||||||||:||||.||.|::|..|||||
  Rat   348 WYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRD 412

  Fly   612 LQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHV 676
            :||::|||::..:|....|..|..|.:|||.:|:|||||..||..|..|..||:|..|..:....
  Rat   413 VQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQ 477

  Fly   677 DKVIPPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPR 736
            .|.|.|.:.:......:.|     ..|||||||..:||:|..||||:.::|.||:.|...||..|
  Rat   478 IKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 542

  Fly   737 IHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGH----ALLREWSLIFYGTTQSIGPN 797
            :.|:|..||..|.||::|.|||...|:|.||:::....:.:    ..|:||||:.|||  |:.|.
  Rat   543 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGT--SVQPY 605

  Fly   798 DPIS-VPK--------------------------PSGSE--ATTPNSSSTTSNLHQAYS-PQYPR 832
            .|.: .||                          |..||  ...|.....|..||..|. ....|
  Rat   606 SPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTR 670

  Fly   833 I-----PPNNFGSSPSGGSKLPLGKVPPPN---------------KSSYVTNNPLLNSAP--PKQ 875
            |     ||.:|.:......|.      .||               |..|..|....:...  |:.
  Rat   671 ICVSSCPPGHFHADKKRCRKC------APNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEG 729

  Fly   876 GYQQISATYGVILGKA--NGKSNNNSKEKTNNKGNKSNNGNK----------------------- 915
            .||.|...   |.||.  |.|:.......|..||..|..|::
  Rat   730 SYQDIKKN---ICGKCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFC 791

  Fly   916 GKSGGSSGNRKEQTTQSTIIQ-----TSTSKNKYYRISQQQQQKNNKQDRNGVQTQR----PKAN 971
            ....|:..:.....|:..:::     .|.|.:.|...|.:...|:.|:..|...|..    ...:
  Rat   792 ATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCS 856

  Fly   972 SGEKSY--------------DEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSS---NSRIPKLF 1019
            |....|              |       ||.....|:..|..|...|....|..   :..|.::|
  Rat   857 SCPSGYLLDLGMCQMGAICKD-------GEYIDEQGHCQICDASCAKCWGPTQDDCISCPITRVF 914

  Fly  1020 E-----------RYEKIQAIFP---ELEPYENSSPKG--KPKQAKQGKQFEVDLFKPTNGGNSRQ 1068
            :           ::|..:...|   ..:..:.|.|..  ..|..|.|:::  .|:|.....|...
  Rat   915 DDGRCVMNCPSWKFELKKQCHPCHHTCQGCQGSGPSNCTSCKADKHGQEY--FLYKGECLENCPM 977

  Fly  1069 GNTKKSPSVPPPSQTMATLSILPILPAGGSSFLP---------DQKILKKQQLLMAAAGVMAPAQ 1124
            |:                      .||.|.:.||         :..:..:    ..:..|:.|..
  Rat   978 GH----------------------YPAKGHACLPCPDNCELCYNPHVCSR----CMSGYVIVPTN 1016

  Fly  1125 VEVEMEEVHATPDYEARKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGND 1189
                    |.....|.|:.:                 |..:|                   ||..
  Rat  1017 --------HTCQKLECRQGE-----------------FQDSE-------------------YGEC 1037

  Fly  1190 MAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECNDSAYMFEDQCYDVCPVHT 1254
            |...:               |.||.|.|....          |..|....||||..||..||..|
  Rat  1038 MPCEE---------------GCVGCTVDDPGA----------CTSCATGYYMFERHCYKACPEKT 1077

  Fly  1255 YPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHS--------LLMSNSLDDKQDPLQAEDRRRRSS 1311
            :. :|::.:           .......|...|.        .|.|.|.....||....|:
  Rat  1078 FG-EKWECK-----------ACGTNCGSCDQHECYWCEEGFFLSSGSCVQDCDPGFYGDQ----- 1125

  Fly  1312 LTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQL 1350
              :|.|     |..|.|:|..|.|...:|||:|..|.||
  Rat  1126 --ELGE-----CKPCHRACETCTGLGYNQCSSCPEGLQL 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	30/78 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	193/293 (66%)
		Peptidase_S8	363..646	CDD:278510	184/282 (65%)
		P_proprotein	701..787	CDD:279782	38/89 (43%)
		FU	1320..>1350	CDD:214589	11/29 (38%)
Pcsk5	XP_038965620.1	S8_pro-domain	40..116	CDD:406785	30/78 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	128..422	CDD:173789	193/293 (66%)
		P_proprotein	507..597	CDD:396185	38/89 (43%)
		GF_recep_IV	637..751	CDD:405525	28/122 (23%)
		VSP	674..>1063	CDD:146106	78/501 (16%)
		GF_recep_IV	889..995	CDD:405525	22/129 (17%)
		VSP	1003..>1324	CDD:146106	50/252 (20%)
		VSP	1293..>1618	CDD:146106
		FU	1642..1684	CDD:214589
		FU	1694..1737	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm44400
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820