DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and pcsk6

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	XP_017947964.1	Gene:	pcsk6 / 100485543	XenbaseID:	XB-GENE-979058	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	594	Identity:	301/594 - (50%)
Similarity:	391/594 - (65%)	Gaps:	55/594 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRS--LSPATHHQTRLDD 291
            :::.|||.||.|.. :|..:|..:|:::||:|  .:::|||.|.:..|||  .|..||...|:
Frog    25 FSNHWAVRIPGGPE-VAAELAAQYGYLSLGQIGNLENYYHFYHSRTIKRSTYASRGTHSFLRM-- 86

  Fly   292 DDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLN--------RGGG 348
            ..:|.|.:||..|.|.|| .:|..|           :.::|||..||.||||:        |.
Frog    87 HPKVEWMQQQEVKKRVKR-HVRTDP-----------NLVNFNDPIWPNMWYLHCSDKSSRCRS-- 137

  Fly   349 LDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRH 413
             :|||:.||:.|.|||.|||:|||||:|.:|||:..||||.||:|||..|.||.|.||.::.|:|
Frog   138 -EMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASNENKH 201

  Fly   414 GTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDD 478
            ||||||||||:||||.|.|||||.|.:||:|||||||||.|||:||.:.|.:|||||:|||||||
Frog   202 GTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDD 266

  Fly   479 GKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEG 543
            ||||||||.||.:||.:|..|||.|.||||:|||||||||.|.|:||||||||:|:||||.||.|
Frog   267 GKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENG 331

  Fly   544 HVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLT 608
            :.|||.|:|:||||||||||...|:::|||||...||..|||||.|||:.||:.||.|::|..|.
Frog   332 YKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLN 396

  Fly   609 WRDLQHIVVRTAKPANLKDPSWSRNGVGRR------VSHSFGYGLMDAAEMVRVARNWKAVPEQQ 667
            |||:||::|:|::..:|:.|.|..||.||:      .||.:|:||:||..||..|:.|:.||.|.
Frog   397 WRDVQHLLVKTSRSVHLRAPDWKTNGAGRKGQKRMWFSHLYGFGLVDADAMVVEAKKWRTVPPQH 461

  Fly   668 RCEINAPHVDKVIPPRTHITLQL-----TVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFL 722
            .| |.|.  |:  .||....:||     ..|.|     ..|.|||||..::|::..||||:|::|
Frog   462 VC-IGAS--DR--RPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRGDLQIYL 521

  Fly   723 RSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGH----ALLREW 783
            .||:.|...||..|..|:|..||..|.||:||.|||..:|.|.||||:....:.:    ..|:||
Frog   522 ISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEW 586

  Fly   784 SLIFYGTTQ 792
            :||||||::
Frog   587 TLIFYGTSE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	29/78 (37%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	191/296 (65%)
		Peptidase_S8	363..646	CDD:278510	184/288 (64%)
		P_proprotein	701..787	CDD:279782	39/89 (44%)
		FU	1320..>1350	CDD:214589
pcsk6	XP_017947964.1	S8_pro-domain	28..104	CDD:374560	29/78 (37%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	115..409	CDD:173789	191/296 (65%)
		P_proprotein	500..590	CDD:366670	39/89 (44%)
		GF_recep_IV	642..761	CDD:373332
		FU	743..785	CDD:214589
		FU	792..834	CDD:214589
		Furin-like_2	798..880	CDD:374219
		PLAC	890..913	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7593
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR42884
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110