Protein Alignment Fur1 and pcsk9

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: XP_002931479.1
• Gene: pcsk9 / 100484989
• XenbaseID: XB-GENE-998025
• Length: 676
• Species: Xenopus tropicalis
• Alignment Length: 615
• Identity: 130/615 - (21%)
• Similarity: 203/615 - (33%)
• Gaps: 219/615 - (35%)

  Fly   341 WYLNRGGGLDMNVIPAWKMG------ITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDD 399
            |.|:|       ::||.:|.      .||..|.|.:||..::|:|.:|:..        |...|.
 Frog   147 WNLDR-------IVPAQQMANQFSPPNTGDSVEVYLLDTSIQSNHREIEGK--------VFVTDF 196

  Fly   400 DPMPHYDMTDSNR-------HGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLD--------GD 449
            ..:|..|.|..:|       |||..||.|...      ..|:|.|.:|..:|:|:        |.
 Frog   197 QNVPEEDGTRFHRQASKCESHGTHMAGVVNGR------DAGVAKGVNVRSLRVLNCQGKGTVSGS 255

  Fly   450 VTDAVEARSLSL----NPQHIDIYSASWGPDDDGKTVDGPGEL---ASRAFIEGTTKGRGGKGSI 507
            :|.....|...:    ||..:.|           ..|.|...:   ||||.:        ..|.|
 Frog   256 LTGLEFIRKTLIEQPYNPLIVLI-----------PFVGGYSRILNAASRALV--------NTGVI 301

  Fly   508 FIWASGNGGREQDNCNCDGYTNSIWTLSISSATEE-----GHVPWYSEKCS-STLATTYSS---- 562
            .|.|:||  .:.|.|            ..|.|:|.     |...:..:..: ..|.|.|.:
 Frog   302 IISAAGN--YKDDAC------------LYSPASEPEVITVGATNYQDQPATMGVLGTNYGNCVDL 352

  Fly   563 GGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKD 627
            ...|:..:..:....:|..|.:|||.:|...|||||::|....:|:..:|:
 Frog   353 FAPGDDIIGASSDCSTCFTSKSGTSQAAAHVAGIAAMILNDKPDLSVSELR-------------- 403

  Fly   628 PSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPR-THITLQLT 691
                     :|:.|.          ..:.|.|..:.||.||.         :.|.| ..:.::|.
 Frog   404 ---------QRLIHF----------STKKAINEVSFPEDQRL---------ITPNRVAGLPVKLL 440

  Fly   692 VNH---CRSV-NYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDN-------SRSGF 745
            .:.   ||:| :.......|.|.:.|..|:.::|..|..:.:.......|.:.       :.:.|
 Frog   441 TDEELFCRTVWSKPSGFARKATTSVQCSGNEEMFSCSSFSRNGKRKGEHIEEGGGRKTCIAHNAF 505

  Fly   746 NQ-----------WPFMSVHTWGESPQ------------------------GNWQLE-----IH- 769
            ..           ||....|....:|:                        |:..|.     ||
 Frog   506 GGDGVYAIARCCIWPKAVCHINSTTPEDGEEPSTVSCSNEDHILTGCSSHHGSGHLSDFVRPIHR 570

  Fly   770 --NEG-------RYMGHAL----------LREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNS 815
              |||       ....|||          ::|:|        .:|..|.::|....|...|..|:
 Frog   571 AGNEGSACVGKSEVTSHALCCHAPDIACKVKEYS--------PVGFMDKVTVSCDEGWTLTGCNA 627

  Fly   816 SSTTSNLHQAYSPQYPRIPPNNFGSSPSGG 845
            .|.:||...|||     |......|:|.||
 Frog   628 YSRSSNTLGAYS-----IDDTCVVSNPKGG 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	75/317 (24%)
		P_proprotein	701..787	CDD:460225	24/152 (16%)
		FU	1320..>1350	CDD:214589
pcsk9	XP_002931479.1	Inhibitor_I9	68..140	CDD:428674
		Peptidases_S8_PCSK9_ProteinaseK_like	147..412	CDD:173790	77/351 (22%)
		PCSK9_C-CRD	442..666	CDD:319350	44/224 (20%)