Protein Alignment Fur1 and tpp2

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: XP_005168067.1
• Gene: tpp2 / 100331669
• ZFINID: ZDB-GENE-121214-290
• Length: 1263
• Species: Danio rerio
• Alignment Length: 1103
• Identity: 215/1103 - (19%)
• Similarity: 353/1103 - (32%)
• Gaps: 317/1103 - (28%)

  Fly   153 GSSPAAPS---SAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKF 214
            |..|.||.   :....|..|.:           :|..|...|....|::.:.|..:.||....|.
Zfish    46 GVDPGAPGMQITTDGKPKIVDI-----------IDTTGSGDVNMSTVVEVKEGSVSGLTGRTLKI 99

  Fly   215 GQSGSSGSNNNHIVGHYTHTWAVHIPNG----DNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVS 275
            ..:..:.|...||          .:.||    ...:.:.:.|:    ...|::|..:..|..:.|
Zfish   100 PAAWVNPSGKYHI----------GVKNGYDFFPKALKERIQKE----RKEKLWDPTHRAALAEAS 150

  Fly   276 KRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQM 340
            :|:           ::.|:.|....|..|.:.:             .....|:.:...:.|
Zfish   151 RRT-----------EEFDQTHTNPSQMEKLQKE-------------ELQCHVELLGMLEKK---- 187

  Fly   341 WYLNRGGGLDMNVIPAWKMGITGKGVV----------VTILDDGLESDHPDIQD----NYDPKAS 391
             |.:.|...|   ..:|..|:|.:.||          .|:|     |.:.:.|:    .:....:
Zfish   188 -YSDPGPVYD---CISWHDGVTWRAVVDTSECGDLSSCTVL-----SSYRERQEFCTLGFAEMLN 243

  Fly   392 YDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDV------ 450
            :.||.:|:...... :|....|||..|...|....:.....|:|.||.:..:::  ||.
Zfish   244 FSVNIYDEGNTLCI-VTSGGAHGTHVASIAAGHFPDEPERNGVAPGAQILALKI--GDTRLSTME 305

  Fly   451 --TDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASG 513
              |..:.|....:| ...|:.:.|:     |:....|.   |....|..|:.......:|:.::|
Zfish   306 TGTGLIRAMIEVIN-YKCDLVNYSY-----GEATHWPN---SGRICEVITEAVQKYNVMFVSSAG 361

  Fly   514 NGGREQDNCNCDGYTNS--------------IWTLSISSATEEGHVPWYSE-KCS-STLATTYSS 562
            |.|.......|.|.|.|              :...|:..........|.|. .|: ..|..:.|:
Zfish   362 NNGPCLTTVGCPGGTTSSVIGVGAYVTPDMMVAEYSLREKLPPNQYTWSSRGPCTDGALGVSISA 426

  Fly   563 GGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVL----QSNQNLTWRDLQHIVVRTAKPA 623
            .|.....|....|..  |....|||.|:|.|.|..||||    |:....|...::..:..||:..
Zfish   427 PGGAIASVPNWTLRG--TQLMNGTSMSSPNACGGIALVLSGLKQNGLRPTVPAVRRALENTAQKV 489

  Fly   624 NLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQR-------CEINAPH-----V 676
            ...:.....:|: .:|..:|.| ||....:...:..:......||       ..:.||.     :
Zfish   490 EEIEVFAQGHGI-IQVERAFDY-LMQHNSLASSSLGFSVSAGSQRGIYLRDATHVTAPSDHGVGI 552

  Fly   677 DKVIPPRT----HITLQLTV------------NHCRSVNYLEHVQAKITLTSQRRG--------- 716
            :.:.|..|    .|:|||.:            :|...:|...||..:|.....|.|
Zfish   553 EPIFPENTENAARISLQLHLALVCNASWVQCPSHLELMNQCRHVNVRIDPQGLREGLHYTEVCGY 617

  Fly   717 DIQLFLRSPA-NTSVTLLTPRIHDNSRSGFNQWPFMSVH-----------------TWGE----S 759
            |.......|. ...:|::.|....:|||  .:..|..||                 :|.|    |
Zfish   618 DTTALSAGPLFRVPITVIIPTKVSDSRS--QELSFTDVHFRPGQIRRHFITVPQGASWAEISLTS 680

  Fly   760 PQGNWQLE-----IH---------NE---------------------GRYMGHALLREWS----- 784
            ..|:...:     :|         ||                     ||.:...:.|.|:
Zfish   681 HTGDVSSKFVLHAVHLVKQRAYRANEFYKFSSLLEKGSLTEAFPVLPGRTLELCIARWWASLGDV 745

  Fly   785 -----LIFYGTTQSIGP-----NDPIS---VPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPN 836
                 :.|:|...|..|     ::.||   |..|...|..:|  :.|..|..|...|...:|.|
Zfish   746 TIDYVISFHGLVTSPSPIHIHASEGISSFEVCSPLRYEDVSP--TITLKNWVQPLRPVSSKIKP- 807

  Fly   837 NFGSSPSGGSKLPLGKVPPPNKSSY---VTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNN 898
                       |.:..|.|.|:..|   :|    .|...||.|....|..   :|.:...:|..:
Zfish   808 -----------LGMRDVLPNNRQLYELVLT----YNFHQPKSGEVTPSCP---LLCELLYESEFD 854

  Fly   899 SKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKY---YRISQQQQQK------ 954
            |:.......||...|    ||.:..::         ......|..|   .::..:||.:
Zfish   855 SQLWLLFDQNKRLMG----SGDAYPHQ---------YSLKLEKGDYTVRLQVRHEQQSELERLKD 906

  Fly   955 ---------NNKQDRNGVQTQR------PKANS-------GEKSY-----DEKSRKVVGEITTNS 992
                     :|....:..:|.|      .||||       .:..|     |:|..|..|.....|
Zfish   907 LPFVVSHRLSNTLSLDVYETHRAALLAKKKANSITLSPGASQPFYITSLPDDKIPKGSGPGGFIS 971

  Fly   993 GNGSIKAAKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYENSSPKGKPKQAKQGKQFEV 1055
            |:..:..::..|::...:|..|..| |::  .|..||..|.|..|.|..||.|:....|:.:|
Zfish   972 GSLVLPKSEFGKKAQGQASAKRQGK-FKK--DIVPIFYHLVPAPNKSKNGKEKEKDPEKEKDV 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	12/78 (15%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	70/330 (21%)
		P_proprotein	701..787	CDD:460225	26/161 (16%)
		FU	1320..>1350	CDD:214589
tpp2	XP_005168067.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	101/518 (19%)
		TPPII	778..963	CDD:463636	42/218 (19%)
		TPPII_N	<1033..1079	CDD:403697