DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and pcsk1

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001131134.1	Gene:	pcsk1 / 100005716	ZFINID:	ZDB-GENE-071009-1	Length:	755	Species:	Danio rerio

Alignment Length:	695	Identity:	316/695 - (45%)
Similarity:	416/695 - (59%)	Gaps:	92/695 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            |.:.|||.||.|... |.::|.:.|:..:.:|  .::||.|..|....|:...|.|...||.:||
Zfish    29 YLNEWAVEIPGGVQN-ARSIADEFGYQLVRQIGALENHYLFKRHSHPSRTKRSADHITKRLSEDD 92

  Fly   294 RVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYL--NRGGG----LDMN 352
            ||.||:||..|.|:||     .|.....:..| ||.: |:|..|.|.|||  .|...    ||::
Zfish    93 RVSWAEQQYEKRRAKR-----APLGVECKDCS-VDKL-FDDPMWNQQWYLQDTRTSSSLPKLDLH 150

  Fly   353 VIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRC 417
            |||.||.||||||||:|:||||||.:|.||..||||.||||.|.:|.||.|.||.|:.|:|||||
Zfish   151 VIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTNENKHGTRC 215

  Fly   418 AGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTV 482
            |||:|..|:|:.|.||:||.:.|||:|||||.||||:||.|:..||.|:|||||||||:||||||
Zfish   216 AGEIAMQADNNKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGYNPDHVDIYSASWGPNDDGKTV 280

  Fly   483 DGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPW 547
            :|||.||.:||..|..||||||||||:||||||||:.|||:|||||:|::|:|||||:::|..||
Zfish   281 EGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSLYTISISSASQQGLSPW 345

  Fly   548 YSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDL 612
            |:|||||||||.||||...::::.:.|||:.||.:||||||||||||||.||.|:.|.:||||||
Zfish   346 YAEKCSSTLATAYSSGDYTDQRITSADLHNECTETHTGTSASAPLAAGIFALALEQNPDLTWRDL 410

  Fly   613 QHIVVRTAKPANL-KDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVA--RNWKAVPEQQRCEINAP 674
            ||:||.|::...| .:|.|.|||.|..|:..||:||::|..:|.:|  :.||.|||:::|.:.
Zfish   411 QHLVVWTSEFDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPKVWKHVPEKKQCIVR-- 473

  Fly   675 HVDKVIPPRT-----HITLQLTVNHC----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSV 730
              |:...||.     .|::::....|    .||..|||||.::::...||||:.:.|.||:.|:.
Zfish   474 --DETFQPRPLKAAGEISIEIPTKACAGQANSVMSLEHVQVEVSIEYTRRGDLHITLTSPSGTTT 536

  Fly   731 TLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEI-HNEGRYMGHALLREWSLIFYGTTQSI 794
            .||..|..|.|.:||..|.|||||||||:|.|.|.|:| ...||......:..|.||.:||::..
Zfish   537 VLLAERERDTSSNGFRNWAFMSVHTWGENPTGTWILKITDTSGRMENEGQIISWKLILHGTSEKP 601

  Fly   795 G-----------------------------------------PNDPISVPKPSGSEATTP--NSS 816
            .                                         ||..|....||.:..:.|  ||.
Zfish   602 EHMKKARVYTPYNAVQNDRRGVEPMEDMMKQEAPTPALKPEIPNQAIPDSPPSTASMSIPEVNSG 666

  Fly   817 STTSN------LHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPP 855
            .:|:|      |..|::.|.|..||.:|...          ::||
Zfish   667 PSTANLALLRLLQSAFNRQMPAAPPKSFQQE----------RIPP 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	29/76 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	191/294 (65%)
		Peptidase_S8	363..646	CDD:278510	183/283 (65%)
		P_proprotein	701..787	CDD:279782	39/86 (45%)
		FU	1320..>1350	CDD:214589
pcsk1	NP_001131134.1	S8_pro-domain	32..108	CDD:293079	29/76 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	124..418	CDD:173789	190/293 (65%)
		Peptidase_S8	161..435	CDD:278510	179/273 (66%)
		P_proprotein	507..594	CDD:279782	39/86 (45%)
		Proho_convert	716..752	CDD:288988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	581	1.000	Inparanoid score	I991
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.800