DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp54D and KIF3B

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_004789.1	Gene:	KIF3B / 9371	HGNCID:	6320	Length:	747	Species:	Homo sapiens

Alignment Length:	592	Identity:	184/592 - (31%)
Similarity:	298/592 - (50%)	Gaps:	91/592 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 DNINVVVRVRPLNDKEKRDRHGSTLQFPGN-GQVILEGNDVGQKRSHNRDSVRVFTYNVVFEPGA 228
            :::.||||.||:|.|||...:...:..... |||     .|...:....:..:.||::.|::..|
Human     8 ESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQV-----SVKNPKGTAHEMPKTFTFDAVYDWNA 67

  Fly   229 TQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRHGLIFRSF 293
            .|.::.|.: .:.:::..::||:.|.|.|||||:|||:|:.|    ..|.|.    :.|:|..||
Human    68 KQFELYDET-FRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEG----IRGDPE----KRGVIPNSF 123

  Fly   294 LYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSGGFFVENLFTVDCEE 358
            .::|..|...::..|:::||::|||.|.:.|||:....:: |.:: .:...|.:|::|.:...:.
Human   124 DHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKR-LELK-ERPDTGVYVKDLSSFVTKS 186

  Fly   359 LDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI-LSDQQTDGGVFLSKH---GKINFVDLA 419
            :.::..|:..|.:||:||:..||:||||||.|..:.| .|:...||    ..|   ||:|.||||
Human   187 VKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDG----ENHIRVGKLNLVDLA 247

  Fly   420 GSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAGNGV 484
            |||...||.::|:.|:||..||.||..||..||:|.|.|  :.|||||||:||:||.|||.||..
Human   248 GSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGK--STHIPYRDSKLTRLLQDSLGGNAK 310

  Fly   485 TLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRDIHALQMENDHLKAA 549
            |:|:|.|.||.||..|||.|||||:|||.|:.||.:..||::||:...:.:|..|:.:.:.....
Human   311 TVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIG 375

  Fly   550 LNLHHQAAPNGGPVENLLELQLDRVSSGGGVPVPKVDLQRLPELDGSELAELVKLYMVENESLRQ 614
            .....:....||             .||||....:.:.:. .|.:|.:          :::..|:
Human   376 RRKRREKRREGG-------------GSGGGGEEEEEEGEE-GEEEGDD----------KDDYWRE 416

  Fly   615 ENNHLFTVRETILRDQEIVCRENERLL----KKLEDVNKVCVRSPLIPARPAISPTTGKETPGTE 675
            :...|...:..|:.|..:|..|..|||    ||:||:.:....:.::.|:  |.....|...|
Human   417 QQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAK--IKAMESKLLVG-- 477

  Fly   676 IWTNPEPLQSPPGPDLPIEQRMSENANRRTDTAQKRIDQKR--IAKNILIMANAFRKPDSDITKE 738
                                  .:|....|:..||.::|||  ||:.        ::.:.:|.::
Human   478 ----------------------GKNIVDHTNEQQKILEQKRQEIAEQ--------KRREREIQQQ 512

  Fly   739 LNLNPEE 745
            :....||
Human   513 MESRDEE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	141/358 (39%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	136/350 (39%)
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	138/353 (39%)
		Smc	<352..>614	CDD:224117	41/226 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..412		8/61 (13%)
		Globular	580..747
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..747
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810