DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp54D and Kif3c

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_445938.1	Gene:	Kif3c / 85248	RGDID:	621538	Length:	796	Species:	Rattus norvegicus

Alignment Length:	659	Identity:	187/659 - (28%)
Similarity:	322/659 - (48%)	Gaps:	140/659 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 VASKSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGN-GQVILEGNDVGQKRSHNRD 213
            :|||:..||.       :.||.|.|||:.||:...|...|..... |||.|.     ..|:...:
  Rat     1 MASKTKASEA-------LKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLR-----NPRAAPGE 53

  Fly   214 SVRVFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTG---PPDLF 275
            ..:.||::.|::..:.|.|:.|.: ::.:|:..::||:.|.|.|||||:|||:|:.|   .|:|
  Rat    54 LPKTFTFDAVYDASSKQADLYDET-VRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPEL- 116

  Fly   276 VGKPNPKDPRHGLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLN--PGSARKPLAVR 338
                      .|:|..:|.::|..|...::..|:::||::|||.|.:.|||:  ||   |.|.::
  Rat   117 ----------RGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPG---KRLELK 168

  Fly   339 WSKKSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI-LSDQQTD 402
            .:.:: |.::::|.:...:.:.::..|:..|.:.|||||..||:.|||||.|..:.: .|::.:|
  Rat   169 ENPET-GVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSD 232

  Fly   403 GGVFLSKHGKINFVDLAGSELTKK--------------------------TMSEGKTLEEANNIN 441
            |...: :.||:|.|||||||...|                          :.|.|:..:||:.||
  Rat   233 GQDHI-RVGKLNLVDLAGSERQNKAGPNTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKIN 296

  Fly   442 KSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLR 506
            .||..||..|::|:.:  |:.|||||||:||:||.|||.||..|:|:|.:.||.:::.|:|:|||
  Rat   297 LSLSALGNVIAALAGN--RSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLR 359

  Fly   507 YASRAKRIRTKPVIKMDPREALILSLKRDIHAL--QMENDHL-------KAALNLHHQAAPNGGP 562
            :|:|||.|:.||.:..||::.|:...:.:|..|  |:|...:       |::......:||.|.|
  Rat   360 FANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYP 424

  Fly   563 ----VENLLELQLDRVSSGGGVPVPKVDLQRLPELDGSELAELVKLYMVE-NESLRQENNHLFTV 622
                :|..:..:.|..::....|.|.::         :.|.:.::.|:.| .|.|.:|
  Rat   425 EGAVIEAWVAEEEDDNNNNHRPPQPTLE---------AALEKNMENYLQEQKERLEEE------- 473

  Fly   623 RETILRDQEIVCRENERLL----KKLEDVNKVCVRSPLIPARPAISPTTGKETPGTEIWTNPEPL 683
            :..|..|:.:|..|.::||    |.|||:.:....:.|:.|:..
  Rat   474 KAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYK--------------------- 517

  Fly   684 QSPPGPDLPIEQRM---SENANRRTDTAQKRIDQKR--IAKNILIMANAFRKPDSDITKELNLNP 743
                    .:|.::   ..|....|:..||.::.||  ||:.        ::.:.::.:|:.|..
  Rat   518 --------AMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQ--------KRREREMQQEMLLRD 566

  Fly   744 EEAHAKQST 752
            ||....:.|
  Rat   567 EETMELRGT 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	134/386 (35%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	129/378 (34%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	132/388 (34%)
		Kinesin	16..367	CDD:278646	129/374 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..292		4/40 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		3/23 (13%)
		GBP_C	<463..571	CDD:303769	29/151 (19%)
		coiled coil	540..551	CDD:293879	4/10 (40%)
		coiled coil	560..571	CDD:293879	4/10 (40%)
		Globular. /evidence=ECO:0000255	633..793
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900