DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and kif26ab

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_005159017.1	Gene:	kif26ab / 58004	ZFINID:	ZDB-GENE-100716-6	Length:	2049	Species:	Danio rerio

Alignment Length:	927	Identity:	202/927 - (21%)
Similarity:	335/927 - (36%)	Gaps:	303/927 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PCPRDILVLSKQSTP-YPA--FAHSVASTQVTMVRR--ASSVPHLNSS-----------GGSSAD 53
            ||| |:..|...:.| :||  ..|.|    ||:..|  .|.:||...|           |.|.:.
Zfish   175 PCP-DMPSLPSSTFPGHPARLMTHGV----VTVSSRPTKSRIPHPAHSVLPVGERQRELGWSQSS 234

  Fly    54 SAGTSG-------SRRGRAPVAGSRGRKT------------------------PSTTSTGQSQRQ 87
            |:..|.       :..|| |:||:....|                        |:....||:: |
Zfish   235 SSSVSTLKPSVQVTMAGR-PLAGTISSVTIQAQQYLEGMWSISRVNNFLPQPNPALGLVGQAE-Q 297

  Fly    88 SSGSSSSMPRSRSLTNGMRRLSPQKGT-----GSSGGTGGGGGSSRNTPYFLRSRENEIGSADTL 147
            |..||.         |.:.|::|.|..     |.:..:.....||....:|:|       :|..|
Zfish   298 SELSSD---------NTISRVNPSKQRCPVQFGQTAPSSSEHPSSAAASFFIR-------AAQKL 346

  Fly   148 EIVASKSTGSEECSTPED------NINVVVRVRPLNDKEKRDRHGS-TLQFPGNGQV-------- 197
            .:.:.:.........|::      |.:.|::..|........|.|| ..:.||.|:|
Zfish   347 NLSSKRKKQQPPLVYPQEPSIYPTNFSAVLQFSPPPAPPCLLRAGSKAKENPGMGKVKVMMRICP 411

  Fly   198 ---ILEGN--------DVGQKR-------------SHNRDSV----RVFTYNVVFEPGATQEDIL 234
               :::.:        |:.:|:             |.:|.:|    ::|.::.||...|:|.::.
Zfish   412 SLGVVDSSESMSFLKVDMRKKQLTLYDPSLHTQPTSVHRRAVLPAPKMFAFDAVFSQDASQAEVC 476

  Fly   235 DYSG-IKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRHGLIFRSFLYLFQ 298
              || :..:|:..:.|.....||:|....|||:|:.|........        |:...:..:||:
Zfish   477 --SGTVAEVIQSVVNGADGCIFCFGHVKVGKTYTMIGTDSSMQSL--------GIAPCAISWLFK 531

  Fly   299 LIKNRKD---VNYVLKASFMEIY--NERVIDLLNPGSARKPLAVRWSKKSGGFF----------V 348
            ||..||:   ..:.::.|.:|||  :|.:.|||:.    .|.......:|.|.:          :
Zfish   532 LINERKEKTGTRFSVRVSAVEIYGKDESLQDLLSD----VPTGSLQDGQSPGVYLREDPICGTQL 592

  Fly   349 ENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSR--SHTILTVHILS---DQQTDGGVFLS 408
            :|...:.....:.....|:..:..|:. :|...|...|  ||.:.|:||..   ::...||: ..
Zfish   593 QNQCELRAPTAEKAALFLDAAIAARST-NHPDADEEDRRNSHMLFTLHIYQYRMEKSGKGGM-SG 655

  Fly   409 KHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTK 473
            ...:::.:||...|   |.:.  |:.:....:..||..||..|.:|::..|   |:|||||:||.
Zfish   656 GRSRLHLIDLGSCE---KVLC--KSRDAGGGLCLSLTALGNVILALANGAK---HVPYRDSKLTM 712

  Fly   474 LLADSLAG-NGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTK-------------------- 517
            ||.|||.. |..|.|||.:|.:..|:||:|.|::.|||..|:|.|
Zfish   713 LLRDSLGNINCRTTMIAHISDSPANYAESLTTIQLASRIHRMRKKKSKYASSSSGGESSCDEGRI 777

  Fly   518 ---PVIKMDPREALILSLKRDIHALQMENDHLK----------------AALNLHHQAAPNGGPV 563
               |.::  |.....::|..|:.:...:.|:..                ||::....:...|.|.
Zfish   778 RRPPHLR--PFHPRTVALDPDLPSFLSDPDYSSSSEQSCDTVIYVGPGGAAISDRELSDNEGPPA 840

  Fly   564 ENLLELQLDRVSSGGGVPVPK--------VDLQ-RLPELDGSELAELVKLYMVENE--------- 610
            ...:...|:|...|...||.:        .:|| ||..:||||......:...||.
Zfish   841 FVPIIPSLNRKQRGKDGPVDRDHFKCNTFAELQERLECIDGSEEPTAFVVESGENSGSSKMDHSA 905

  Fly   611 ------------SLRQENNHLFTVRETI----------------------------------LRD 629
                        |.:.....|.:.:::|                                  |||
Zfish   906 NKLKEGSSCISVSPKTPTKVLSSTQDSISKKSISVTSKLPSSPKHKSKLEHSKLQSAASDKDLRD 970

  Fly   630 Q-EIVCR---ENERLLKKLEDVNKVCVRSPLIPARPAISPTTGKETPGTEIWTNPEP-------- 682
            . |.|||   :.|::  ::.:...:|              ||||::. |.|..|.||
Zfish   971 MCENVCRTSADGEKV--QMSESGSLC--------------TTGKQSK-TIISQNSEPVVREKVFF 1018

  Fly   683 ---LQSPPGPDLPIEQR 696
               |..|..|  |.:||
Zfish  1019 NKKLPKPAPP--PPQQR 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	106/435 (24%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	102/404 (25%)
kif26ab	XP_005159017.1	KISc	402..752	CDD:276812	93/373 (25%)
kif26ab	XP_005159017.1	Kinesin	438..750	CDD:278646	88/335 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900