DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp54D and KIF17

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_065867.2	Gene:	KIF17 / 57576	HGNCID:	19167	Length:	1029	Species:	Homo sapiens

Alignment Length:	633	Identity:	199/633 - (31%)
Similarity:	302/633 - (47%)	Gaps:	114/633 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 INVVVRVRPLNDKEKR-----------DRHGSTLQFPGNG-----QVILEGNDVGQKRSHNRDSV 215
            :.||||.||:|.:|:.           .|....:|.||..     |...:|       :::.|.|
Human     6 VKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDG-------AYHVDHV 63

  Fly   216 RVFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPN 280
            ....||.:..|               ::|...||::.|.|.||||||||:.|:.|.||
Human    64 TEQIYNEIAYP---------------LVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPD------- 106

  Fly   281 PKDPRHGLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSG- 344
            |...| |:|.|:|.::|:.::..::..::::||::|||||.|.|||...:.:| |.::...:.|
Human   107 PPSQR-GIIPRAFEHVFESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQK-LELKEHPEKGV 169

  Fly   345 ---GFFVENLFTV-DCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGV 405
               |..:..:.:| .||.      ::|.|.:||:||...||..|||||:|.|:.|......:.|.
Human   170 YVKGLSMHTVHSVAQCEH------IMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGK 228

  Fly   406 FLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQ 470
            ...:.||:|.|||||||...||.:.|:.|:||..||.||..||..||:|.|.  |..|:|||||:
Human   229 DHLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALVDG--RCKHVPYRDSK 291

  Fly   471 LTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRD 535
            ||:||.|||.||..|||:||:|||..|:.|||:|||||:|||.||.||.|..||::||:...:.:
Human   292 LTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEE 356

  Fly   536 IHAL------QMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSSGGGVPVPKVDLQRLPELD 594
            |..|      ||....|.|.|:  .|..|:...||..|..|          ||.:.|::...:|.
Human   357 IKKLKAILTQQMSPSSLSALLS--RQVPPDPVQVEEKLLPQ----------PVIQHDVEAEKQLI 409

  Fly   595 GSE----LAELVKLYMVENES-LRQENN----------HLFTVRETILRDQEIVCRENERLLKKL 644
            ..|    ||.|...|..|.|| .|.|.:          .|.|:.|.:.::.|.|.:..  :|.|.
Human   410 REEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVRLSTLEENLRKETEAVLQVG--VLYKA 472

  Fly   645 EDVNKVCVRS-----PLIPARPAISPTTGKETPGTEIWTNPEPLQSPPGPDLPIEQRMSENANRR 704
            |.:::....|     |.......:.|         ::::..:.|.|.......:..|.:|..  :
Human   473 EVMSRAEFASSAEYPPAFQYETVVKP---------KVFSTTDTLPSDDVSKTQVSSRFAELP--K 526

  Fly   705 TDTAQKRIDQKRIAKNIL---IMANAFRKPDSDITKELNLNPEEAHAK 749
            .:.::..|.......:.|   .::.||..|:.....|:::..||:.::
Human   527 VEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSR 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	144/373 (39%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	138/365 (38%)
KIF17	NP_065867.2	Motor_domain	4..335	CDD:277568	140/367 (38%)
		Kinesin	11..335	CDD:278646	137/362 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..569		7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..931
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1029
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910