DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp54D and kif15

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_002666969.1	Gene:	kif15 / 573988	ZFINID:	ZDB-GENE-050622-16	Length:	1376	Species:	Danio rerio

Alignment Length:	675	Identity:	204/675 - (30%)
Similarity:	300/675 - (44%)	Gaps:	115/675 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 KSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRV 217
            |:|.....::..|.|.|.||||||.       .|:.|...|:..:.|..:.....|.|.:...|.
Zfish     6 KATAEANTNSDGDAIKVFVRVRPLT-------QGTGLSTDGDHSLCLTVSSPQTVRLHCKPEPRT 63

  Fly   218 FTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPK 282
            |||:.|.:...:||::.. |..|.|:|..:.|::.|.|.|||||||||.|:.||.:|    .|..
Zfish    64 FTYDHVADMNTSQEEVFS-SVAKNIVESCMNGYNGTIFAYGQTGSGKTFTMLGPSEL----DNFS 123

  Fly   283 DPRHGLIFRSFLYLFQLIKNRK------DVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSK 341
            |...|:|.|||.|||.|| ||:      ..:::.|.||:|||||::.|||:  |....|.:|...
Zfish   124 DELRGVIPRSFEYLFFLI-NREVERSGGTKSFLCKCSFIEIYNEQIYDLLD--SVSTSLFLREDI 185

  Fly   342 KSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGVF 406
            |. |.|||...........:...||..|.|||.|.|.:||..|||||.:.|: .|..::|...|.
Zfish   186 KR-GVFVEGSVEKYAASAAEAYQVLSMGWRNRRVASTSMNRESSRSHAVFTM-TLESKETGQEVV 248

  Fly   407 LSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSD-SKKRTGHIPYRDSQ 470
            ..:..::|.|||||||..:.|.:||..|:||::||:|||.||..|.:|.| |..:..||.||||:
Zfish   249 NIRTSQLNLVDLAGSERQRDTHTEGSRLKEASSINRSLMCLGQVIMALMDVSNGKNRHICYRDSK 313

  Fly   471 LTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRD 535
            ||.||.|||.||..|.:||.|.|......|||:||::|.|||.|:.|.::..|        .:.:
Zfish   314 LTFLLRDSLGGNAKTYIIANVHPGSKCFGETLSTLQFAQRAKLIKNKAMVNED--------TQGN 370

  Fly   536 IHALQMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSSGGGVP------------------- 581
            :..||.|...||..|   ..|...|    .::||.....:|....|
Zfish   371 VRQLQAEVRKLKEQL---ANALSQG----RIVELAPTDATSDQSEPEVSYKTQFIQAMNFWKKIH 428

  Fly   582 -VPKVDLQRLPELDGSELAELVKLYMVENESLRQENNHLFTVRETILRDQEIVCRENERLLKKLE 645
             ..|...|::.:|:.: .|:..|........|:..::|:..:::.:...|..|  |.|.|.|:|:
Zfish   429 EEKKALQQKVSQLEAA-WAQKEKFIQSNRMILKFRDDHIAQLKKELQTGQRSV--EPEELNKQLQ 490

  Fly   646 D-------------------VNKVCVRSPLIPARPAISPTTGKETPG-------------TEIWT 678
            |                   .....:|..:...|...|..:..|:..             .|...
Zfish   491 DEIRLLRDQVEHNPRMMRYAAENCSLREEIRALRALDSVKSAMESKAQSLTALEKTFLQLLEAQK 555

  Fly   679 NPEPLQSPPGPDLPIE---------QRMS----ENANRRTDTAQ-----KRIDQKRIAKNILIMA 725
            ..:...:||....|:.         :||.    :..:..|.|.|     |.:.:|::|: :....
Zfish   556 TEDSNGAPPTYSTPVTMETLSSVSMERMKVQLLQKQSELTATIQAFEEFKEVTKKQVAE-LESER 619

  Fly   726 NAFRKPDSDITKELNLNPEEAHAKQ 750
            ..|.|.:..:.|.|...  :||:||
Zfish   620 RYFEKSNKHLEKILEAT--KAHSKQ 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	149/360 (41%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	145/352 (41%)
kif15	XP_002666969.1	KISc_KLP2_like	18..367	CDD:276824	151/373 (40%)
		KISc	19..364	CDD:214526	149/361 (41%)
		SbcC	371..1007	CDD:223496	51/285 (18%)
		Kinesin-relat_1	462..547	CDD:289481	13/86 (15%)
		Ax_dynein_light	<602..658	CDD:287215	11/44 (25%)
		GBP_C	<707..805	CDD:303769
		Mplasa_alph_rch	709..1360	CDD:275316
		coiled coil	776..788	CDD:293879
		coiled coil	794..805	CDD:293879
		HMMR_C	1262..>1372	CDD:292530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810