DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and cmet

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster

Alignment Length:	693	Identity:	181/693 - (26%)
Similarity:	302/693 - (43%)	Gaps:	170/693 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 NINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRS-HNRDS-VRVFTYNVVFEPGA 228
            :|.|.::|||..              ||    :.....|.::|| |..|| ...:.::.||:.||
  Fly     8 SIQVCIKVRPCE--------------PG----LTSLWQVKERRSIHLADSHAEPYVFDYVFDEGA 54

  Fly   229 TQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRHGLIFRSF 293
            :.:::.|... |.|:...::||:.|.|.||||.||||:|:.|      .:.||     |::..:.
  Fly    55 SNQEVFDRMA-KHIVHACMQGFNGTIFAYGQTSSGKTYTMMG------DEQNP-----GVMVLAA 107

  Fly   294 LYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSGGFFVENLFTVDCEE 358
            ..:||.|.:..:.:::|:..::|||||::.||||    :|...::..:...|     :..|:|||
  Fly   108 KEIFQQISSETERDFLLRVGYIEIYNEKIYDLLN----KKNQDLKIHESGNG-----IVNVNCEE 163

  Fly   359 L-----DDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI---LSDQQTDGGVFLSKHGKINF 415
            .     .|||.:|..|.:.|.||...||:.|||||.|..:.|   .||...|..|..|   .:|.
  Fly   164 CIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQS---VLNL 225

  Fly   416 VDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLA 480
            |||||||...:|.:.|..|:|..:|||||:.|...|.|||::.... ...||||:||::|..||.
  Fly   226 VDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNR-FTNYRDSKLTRILQASLG 289

  Fly   481 GNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILS-LKRDIHAL----- 539
            ||..|.:|..:.|:...  |:.:||.:|:|||:||.||.:.....:|.::. |:|:|..|
  Fly   290 GNAFTSIICTIKPSIME--ESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLA 352

  Fly   540 --------QMENDHLKAAL--NLH-----HQAAPNG----------------------GPVENLL 567
                    |.:.:||:..:  ::|     |..:..|                      |..|:.:
  Fly   353 EEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRI 417

  Fly   568 ELQLDRVS----------SGGGV---PVPKVDLQRLPELD-GSELAELVKLYMVENESLRQENNH 618
            : |..:||          |..|.   .:||. :..|..|| |:|...      :..|.|..|...
  Fly   418 D-QFPKVSHLPKPVFFHTSNAGKRWDNIPKT-INILGSLDIGTESNS------ISEEFLPAECID 474

  Fly   619 LFTVRETILRDQEIVCRENERLLKKLEDVNKVCVRSPLIPARPAISPTTGKETPGTEIWTNPE-- 681
            ..:.|..:|:..        ..:::|.|:       ||.|..|..:....||....:::|:.|
  Fly   475 FGSPRPDVLKPM--------LTIRQLPDL-------PLTPKGPLTTDKIKKEIQDLQMFTSLEKH 524

  Fly   682 ---PLQSPPGPDLPIEQRMSENANRRTDTAQKRIDQKR----IAKNILIMA---NAFRKPDSDIT 736
               ..:...|    ::::::|...:|.:..|:.:.:|.    :.|.:..:.   .|.....|::.
  Fly   525 FEVECEEVQG----LKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELE 585

  Fly   737 KELNLNPE-------------------EAHAKQSTEFMPDMLT 760
            ::|:...:                   |||.|.|...:.|:|:
  Fly   586 EKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLS 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	125/363 (34%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	119/355 (34%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	125/364 (34%)
		Motor_domain	8..321	CDD:277568	121/357 (34%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840