DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and Kif9

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_006244056.1	Gene:	Kif9 / 501059	RGDID:	1565187	Length:	860	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	189/716 - (26%)
Similarity:	321/716 - (44%)	Gaps:	176/716 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 STGSEECST----PEDNINVVVRVRPLND-KEKRDRHGSTLQFPGNGQVILEGN---DVGQKRSH 210
            |:|.|:.:.    ....:...|||:|.:| ..:..::|             |.|   |:..|:..
  Rat    60 SSGHEQVALGRMGTRKKVQAFVRVKPTDDFAHEMIKYG-------------EDNKSIDIHLKKDT 111

  Fly   211 NRDSVR------VFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLT 269
            .|.:|.      .|..:.|....:  :|::..:..|..:...::|::.|..||||||:|||:|:|
  Rat   112 RRGAVNNQQTDWSFKLDGVLHDAS--QDLVYETVAKDAVSQALDGYNGTIMCYGQTGAGKTYTMT 174

  Fly   270 GPPDLFVGKPNPKDPRH-GLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNP----G 329
            |..:.:         :| |::.|:...:|::|:.|......::.|::|||||.:.|||:.    |
  Rat   175 GATENY---------KHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNENLFDLLSTLPYVG 230

  Fly   330 SARKPLAVRWSKKSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVH 394
            .:..|:.:  .:...|.|::.|......:.:|..::|.||..||.:.||.||.:|||||.|.|::
  Rat   231 PSVTPMTI--VENPQGVFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIY 293

  Fly   395 I------LSDQQTDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISS 453
            :      |||::     :::  .|||.|||||||...||.|||:.|:||..|||||..|...|.:
  Rat   294 MEAHSRTLSDEK-----YIT--SKINLVDLAGSERLSKTGSEGRVLKEATYINKSLSFLEQAIIA 351

  Fly   454 LSDSKKRTGHIPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHA----ETLNTLRYASRAKRI 514
            |.|..:  .|||:|.|:||..|.|||.||...:::..:    |..|    |||::||:|||.|.:
  Rat   352 LGDQNR--DHIPFRQSKLTHALKDSLGGNCNMVLVTNI----YGEAAQLDETLSSLRFASRMKLV 410

  Fly   515 RTKPVI--KMDPREALILSLKRDIHALQMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSSG 577
            .|:|.|  |.| .|.::.:|::::..|:.|   |....:|.::...|..|::   |:|:..::|
  Rat   411 TTEPAINEKYD-AERMVKNLEKELALLKQE---LAIHDSLSNRTLVNYDPMD---EIQIAEINS- 467

  Fly   578 GGVPVPKVDLQR-----LPELDGSELAELVKLYMVENESLRQENNHLFTVRETILRDQEIVCREN 637
                    .::|     |.|:|...|.::.:::......|.|:...:    |:.||.:..:..:|
  Rat   468 --------QVRRYLEGTLDEIDIINLRQIQEVFNQFRVVLSQQEQEV----ESALRRKYTLIDKN 520

  Fly   638 E----RLLKK--LEDVNKVCVRSP--------LIP--ARP----------------------AIS 664
            :    ..::|  |.||....|..|        :.|  .:|                      |.|
  Rat   521 DFAAISAVQKAGLMDVEGHLVGEPDGQSFGLGVAPFSVKPGKKSKTKKTTKDQFSSSARKEGASS 585

  Fly   665 PTTGKETPGTEI-----------------------WTNPEPLQS--------------PPGPDLP 692
            |.:||:...|.|                       .::.|||.|              ||...:.
  Rat   586 PVSGKDFDMTSISKTQLIPSSKEGDLKDMLVRERETSSIEPLPSDSPKEESRALRPSTPPSKPVA 650

  Fly   693 IEQRMSENAN--RRTDTAQKRI--DQKRIAKNILIMANAFRKPDSDITKELNLNPEEAHAKQSTE 753
            .|:..:|..:  .|.....|.|  ::|:.|.......||. |.:.|:|||. ||.:::..::..|
  Rat   651 FEEFKNERGSEINRIFKENKSILNERKKRASETTQRINAI-KQEIDVTKEA-LNFQKSLREKQGE 713

  Fly   754 F 754
            :
  Rat   714 Y 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	123/378 (33%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	120/370 (32%)
Kif9	XP_006244056.1	KISc_KIF9_like	76..408	CDD:276826	120/370 (32%)
Kif9	XP_006244056.1	Kinesin	82..410	CDD:278646	120/366 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900