DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and Klp64D

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	189/592 - (31%)
Similarity:	299/592 - (50%)	Gaps:	87/592 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 DNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRVFTYNVVFEPGAT 229
            :|:.||||.||::..|......|.:......:.|    .|.:..:...:..:.:.::.||:.|:.
  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAI----TVMKPNATANEPPKTYYFDNVFDGGSN 79

  Fly   230 QEDILDYSGIKR-IIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRHGLIFRSF 293
            |.|:  |....| |::..:||::.|...|||||:|||:|::|.||    .|..|    |:|..:|
  Fly    80 QMDL--YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPD----SPQTK----GIIPNAF 134

  Fly   294 LYLF-QLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSGGFFVENLFTVDCE 357
            .::| .:.|.:::..::::.|:||||||.|.|||.. ...|.|.|: .:...|.||::|......
  Fly   135 AHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGK-DVGKSLEVK-ERPDIGVFVKDLSGYVVH 197

  Fly   358 ELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGVFLSKHGKINFVDLAGSE 422
            ..|||..::..|.:|||||:..||..|||||.|.::.:...:..:|.|...:.||:..|||||||
  Fly   198 NADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSE 262

  Fly   423 LTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAGNGVTLM 487
            ...||.:.|:.|:||..||.||.|||..||:|.|.|  :.|||||:|:||:||.|||.||..|:|
  Fly   263 RQSKTQASGQRLKEATKINLSLSVLGNVISALVDGK--STHIPYRNSKLTRLLQDSLGGNSKTVM 325

  Fly   488 IACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRDIHALQM---ENDHLKAA 549
            .|.:|||..|:.||::|||||||||.|:.:..|..:|::||:...:.:|..|:.   |.|.|:
  Fly   326 CATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLE-- 388

  Fly   550 LNLHHQAAPNGGPVENL--------LELQLDRVSSGGGVPVPKVDLQRLPELDGSELAELVKLYM 606
                 :..|:....|:.        ||::|:..:.......||    :..|...:|..||.|.
  Fly   389 -----EEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPK----KKREKTDAEKEELAKR-- 442

  Fly   607 VENESLRQENNHLFTVRETILRDQEIVCRENERLLKKLEDVNKVCVRSPLIPARPAISPTTGKET 671
             :||. ::|..|..|.:|| ||::          |..||                      ||..
  Fly   443 -KNEH-QKEIEHAKTEQET-LRNK----------LVSLE----------------------GKIL 472

  Fly   672 PGTEIWTNPEPLQSPPGPDLPIEQRMSE-NANRRTDTAQKRIDQKRIAKNILI--MANAFRKPDS 733
            .|.|     ..|:.....:|.:||.::| ..:.:::.|.|:..|::..:.|.|  ..:..:...:
  Fly   473 VGGE-----NLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDAST 532

  Fly   734 DITKELN 740
            .|||:::
  Fly   533 GITKKIH 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	139/355 (39%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	136/347 (39%)
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	138/350 (39%)
		Kinesin	26..352	CDD:278646	134/343 (39%)
		RILP-like	<437..556	CDD:304877	32/145 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840