DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and Klp59C

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	150/545 - (27%)
Similarity:	228/545 - (41%)	Gaps:	111/545 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HSVASTQVTMVRRASSVPHL----NSSGGSSADSAGTSGSRRGRAPVAGSRGRKTPSTTSTGQSQ 85
            |:|...::.:.......||:    ..|||::|.:                  .:|.|.:.....|
  Fly    43 HTVRGKELPLELVVLMNPHIFDSPRCSGGNAASA------------------NQTASISPRSMKQ 89

  Fly    86 RQSSGSSSSM-----PR----------------SRSLTNGMRRLSPQKGT---GSSGGTGGGGGS 126
            |.::||.|.:     ||                .|......||...|..|   ...|.....|..
  Fly    90 RIATGSLSPVLATAPPRQQTAPPVREDEVVHQAERMRKERERRREAQARTRLDREQGKNEDPGNP 154

  Fly   127 SRNTPYFLRSRENEIGSADTLEIVASKSTGSE-ECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQ 190
            :......:|.:..::.|    :.|.|.:|... .|    ..|.|.||.|||..||..||....:.
  Fly   155 NWEVARMIRLQREQMES----QRVRSGTTNERINC----HQIMVCVRKRPLRRKELADREQDVVS 211

  Fly   191 FPGNGQVILEGNDVGQKRSH--------NRDSVRVFTYNVVFEPGATQEDILDYSG---IKRIIE 244
            .|....::     |.:.|.|        |..    |.::.||:...:...:.:::.   ||.|.:
  Fly   212 IPSKHTLV-----VHEPRKHVNLVKFLENHS----FRFDYVFDEECSNATVYEFTARPLIKHIFD 267

  Fly   245 MGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRH-----GLIFRSFLYLFQLIKN-- 302
            .|:    .|.|.|||||||||:|:.|.   |.|       ||     |:...:...:|..:|.
  Fly   268 GGM----ATCFAYGQTGSGKTYTMGGQ---FPG-------RHQSSMDGIYAMAAKDVFSTLKTVP 318

  Fly   303 RKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSGGFFVENLFTVDCEELDDLLAVLE 367
            ...:|..:..||.|||..||.|||.||   ||.......::....|..|.....:...::|.:||
  Fly   319 YNKLNLKVYCSFFEIYGTRVFDLLMPG---KPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLE 380

  Fly   368 EGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGVFLSKHGKINFVDLAGSEL-TKKTMSEG 431
            .|...|..|..:.|..|||||.:..:.:    ::..|..|  |||.:.:||||:|. ...:.::.
  Fly   381 LGNSVRTSGHTSANSKSSRSHAVFQIVL----RSAAGEKL--HGKFSLIDLAGNERGADNSSADR 439

  Fly   432 KTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAGNG--VTLMIACVSPA 494
            :|..|.:.|||||:||..||.:|.   :::.|:|:|.|:||::|.||..|..  .|.|||.:||.
  Fly   440 QTRLEGSEINKSLLVLKECIRALG---RQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPC 501

  Fly   495 HYNHAETLNTLRYASRAKRIRTKPV 519
            .::...||||||||.|.|.:..:.:
  Fly   502 LHSVEHTLNTLRYADRVKELSVESI 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	120/375 (32%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	119/366 (33%)
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	119/366 (33%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	116/361 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940