Protein Alignment Klp54D and neb

DIOPT Version :10

• Sequence 1: NP_001303355.1
• Gene: Klp54D / 47216
• FlyBaseID: FBgn0263076
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Alignment Length: 713
• Identity: 206/713 - (28%)
• Similarity: 327/713 - (45%)
• Gaps: 175/713 - (24%)

  Fly    68 AGSRGRKTPSTTSTGQSQRQSSGSSSSMPRSRSLTNGMRRLSPQKGTGSSGGTGGGGGSSRNTPY 132
            :||..:..|..|:.     .:..:.||:.|:.:.|.| |..:|  |||.|..:
  Fly    56 SGSTPQPKPKPTAL-----NACYTPSSLYRNANSTPG-RAKTP--GTGKSSCS------------ 100

  Fly   133 FLRSRENEIGSADTLEIVASKSTGSEEC--STPEDNINVVVRVRPLNDKE-KRDRHGSTLQFPGN 194
              |::|.     |:|         .|.|  .:.|.|:.|.|||||||..| .|.:..:.:|..||
  Fly   101 --RTKER-----DSL---------MESCLSVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGN 149

  Fly   195 GQVILEGNDVGQKRSHNRDS----VRVFTYNVVF---EPG----ATQEDILDYSGIKR-IIEMGI 247
                  .|::..:...:.|:    ...|:|:.|:   :|.    |.|..:  :.|..| :|:...
  Fly   150 ------SNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKV--FEGTARPLIDTAF 206

  Fly   248 EGFSCTAFCYGQTGSGKTHTLTGPPDL----FVGKPNPKDPRHGLIFRSFLYLF---QLIKNRKD 305
            ||::...|.||||||||::::.|...|    ..|.| |.| ..|:|.|....||   :.:|:::.
  Fly   207 EGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGP-PHD-EAGIIPRFCHELFRRIEAVKSQQQ 269

  Fly   306 VNYVLKASFMEIYNERVIDLLNPGSA-----------------RKPLAVRWSKKSGGFFVE-NLF 352
            :...::.|:.|||||::.|||:...|                 |..|.||.....|.:.|: :..
  Fly   270 LQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAH 334

  Fly   353 TVDC-EELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI-LSDQQTDGGVF--------- 406
            :||. ..|.:.|||   |...||..|.||||.|||||:|..:.: |:|..:|.|:.
  Fly   335 SVDSYSALRNWLAV---GNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTAS 396

  Fly   407 ---LSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGH----- 463
               .::..||:.|||||||....:.|.|:.:.|..:|||||:.||..|::|:||:|...:
  Fly   397 SLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGS 461

  Fly   464 ------IPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKM 522
                  :|||:|.||.||.::|.||..|:|:|.:|||..:..|||.|||||.:|:.|..:..:..
  Fly   462 GTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNE 526

  Fly   523 DPREALILSLKRDIHALQMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSSGGGVPVP-KVD 586
            .|.:.:|    ||:.|   |.|.||:..|.:.:..               |:|.....||| |:.
  Fly   527 SPHDKII----RDLRA---EVDRLKSLRNEYERQR---------------RLSGNSNNPVPRKII 569

  Fly   587 LQRLPELDGSELAEL-VKLYMVENESLRQENNHLFTVRETILRDQEIVCRENE-RLLKK----LE 645
            ::  ..:|.:|:..| .:|...|.|..|.:.:.:..::|.  .||    |::| |:||:    ||
  Fly   570 IE--TSVDETEVEALRQQLAERERELSRAQKSWMEKLKEA--EDQ----RKSELRVLKRRGLALE 626

  Fly   646 ---DVNKVCVRSPLIPARPAISPTTGKETPGTEIWTNPEPL------QSPPG-----PDLPIE 694
               :..:.|:.:  :.|.|.:|        ||..:..|:.|      :.|.|     ||:.::
  Fly   627 LTAEQKQACLVN--LTADPILS--------GTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLD 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	139/416 (33%)
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	139/418 (33%)
		SMC_N	514..>615	CDD:481474	29/130 (22%)
		FHA_KIF14	627..741	CDD:438759	12/63 (19%)