DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and CG14535

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	145/742 - (19%)
Similarity:	253/742 - (34%)	Gaps:	216/742 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 SSSSMPRSRSLTNGMRRLSPQKGTGSSGGTGGGGGSSRNTPYFLR---SRE-NEIGSADTLEIVA 151
            |:|:|.|:......::|..|..                 .|..:|   ||| ..:|....:..||
  Fly     5 STSNMSRNGGFCGALQRAPPPM-----------------PPTLIRRLSSRECYGVGKVKVMLRVA 52

  Fly   152 SKSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVR 216
            .:...|.  .|..|.:.:        ||:||.   .||..|   :.........|:|:....:.:
  Fly    53 DRDRNSG--GTEPDFMAL--------DKKKRQ---VTLTDP---RTACPPPQAAQERAPMVAAPK 101

  Fly   217 VFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNP 281
            :|.::.:|.....|.|:. .|.:..:|...:||........|...:|:..|:.|  :|..|..:.
  Fly   102 MFAFDNLFTGEDKQSDVC-ASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLG--ELGGGSGSG 163

  Fly   282 KDPRHGLIFR------SFLYLFQLIKNRKD---VNYVLKASFMEIYNERVIDLLNPGSARKPLAV 337
            .....|:...      :..:|::.|:.|:.   ..:.::.|.:.:            ||.||.|:
  Fly   164 SASGSGVACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGV------------SATKPDAL 216

  Fly   338 RW---------SKKSGGFFVENLFTVDCEEL-----DDLLAVLEEGMRNRAVGSHAMNDHSS--- 385
            ..         |..|.|.::.:.|.....||     :.....|:..:..|...|.:....||
  Fly   217 SQDLLISHAAESDDSPGIYLRDDFLGGPTELRAPTAERAALFLDSALAGRLKSSGSTASGSSGCA 281

  Fly   386 ---RSHTILTVHILSDQQTDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVL 447
               .|..|.|:|:.....:..|.......:::.:||.|.    ...:.|..|....||
  Fly   282 APLESALIFTLHVYQYSLSRKGGVAGGRSRLHIIDLGGC----ANRNGGLPLSGIGNI------- 335

  Fly   448 GYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAGNGVTLMIACVSPAH----YNHAETLNTLRYA 508
              .::.||..:    |.|::|..||.||.|.||  .:|..:|.|  ||    .::.:.|:|::.|
  Fly   336 --LLAILSGQR----HPPHKDHPLTPLLKDCLA--PITCHVAIV--AHVRPEQSYQDALSTIQIA 390

  Fly   509 SRAKRIRTKPVIKMDPREALILSLKRDIHALQMENDHLKAALNLHHQAAPNG-----GPVENLLE 568
            ||..|:|                  |..|.:.|     ..|:.|......||     |...:..|
  Fly   391 SRIHRLR------------------RRKHRVPM-----PLAVGLAQGLGGNGSSAGSGADPSSSE 432

  Fly   569 LQLDRV---------SSGGGVPVPKVDLQRLPELDGSE----LAELVKLYMVENESLRQENNHLF 620
            :..|.|         :.|...||      .||.|...:    :::.:|...:|....:..:|...
  Fly   433 ISADTVIYMGPNDDATDGEHPPV------YLPSLTAGDNRGVMSKALKGSGLEKPPSKSASNSPM 491

  Fly   621 TVRETILRDQEIVCRENERLLKKLEDVNKVCVR---------SPLIPARPAISPTTGKETPGTEI 676
            .:::.:..::          .|||...:...::         ||:||          .|.|..:.
  Fly   492 MMKKAMAAEK----------AKKLPGSHTGSLKRQAGAGACSSPMIP----------HEQPQIQA 536

  Fly   677 WTNPEPL-----------QSPPG-------PDLPIEQRMSENANRRTDTAQKRIDQKRIAKNILI 723
            ..:|.|:           .||.|       |...:||.   .|..|..|.::.||..|:::
  Fly   537 MGSPIPIPRHMVSKGSMVPSPKGSPMRRAHPGAALEQL---EAGMRKITEEQWIDGPRVSR---- 594

  Fly   724 MANAFRKPDSDITKELNLNPEEAHAKQ 750
                     :.:.:..:|..|..|.||
  Fly   595 ---------AKVAEARHLMREVNHVKQ 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	80/386 (21%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	78/378 (21%)
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	83/401 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000