DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp54D and Kif26a

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_006240697.1	Gene:	Kif26a / 314473	RGDID:	1307957	Length:	1881	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	156/804 - (19%)
Similarity:	268/804 - (33%)	Gaps:	295/804 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SSGGSSADSAGTS-----------GSRRGR---APVAGSRGRKTPSTTSTGQSQ----------R 86
            |:|||:|.||..|           .|:|.:   .|...:||..|.:|..:|..|          .
  Rat   285 SAGGSTAPSAAASFFIRAAQKLSLASKRKKHPPPPAPSARGSSTYATDFSGTLQLWPPPVPPCLL 349

  Fly    87 QSSGSSSSMPRSRSLTNGMRRLSPQKGTGSSGGTGGGGGSSRNTPYFLR--SRENEIGSADTLEI 149
            :::..:...|.:......|.|:.|.:|...|.          .:..||:  ||:.::...|
  Rat   350 RAASKAKENPSNFGKVKVMLRIWPAQGVQRSA----------ESTSFLKVDSRKKQVTLYD---- 400

  Fly   150 VASKSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDS 214
               .:.|...|:..                    ||..|...|
  Rat   401 ---PAAGPPGCAGL--------------------RHAPTAPVP---------------------- 420

  Fly   215 VRVFTYNVVFEPGATQEDILDYSG-IKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTG----PPDL 274
             ::|.::.:|...:.|.::.  || :..:::..:.|.....|.:|....||::|:.|    |..|
  Rat   421 -KMFAFDAIFPQDSEQAEVC--SGTVADVLQSVVGGADGCIFSFGHMSLGKSYTMIGKDSSPQSL 482

  Fly   275 FVGKPNPKDPRHGLIFRSFLYLFQLIKNRKD---VNYVLKASFMEI--YNERVIDLL-------- 326
                        |::..:..:||:||..||:   ..:.::.|.:|:  :::.:.|||
  Rat   483 ------------GIVPCAISWLFRLIDERKERLGTRFSIRVSAVEVCGHDQSLRDLLAEVASGCL 535

  Fly   327 ---------------------NPGSARKPLAVRWSKKSGGFFVENLFTVDCEELDDLLAVLEEGM 370
                                 |....|.|.|     :...|:           ||..||.
  Rat   536 QDTQSPGVYLREDPVCGTQLRNQNELRAPTA-----EKAAFY-----------LDAALAA----- 579

  Fly   371 RNRAVGSHAMNDHSSR-SHTILTVHILS---DQQTDGGVFLSKHGKINFVDLAGSELTKKTMSEG 431
              |:.......:.:.| ||.:.|:|:..   ::...||: .....:::.:||...|.......|.
  Rat   580 --RSTSRAGCGEDARRTSHMLFTLHVYQYRVEKCGQGGM-SGGRSRLHLIDLGSCEAAPSRGGEA 641

  Fly   432 KTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAGNG-VTLMIACVSPAH 495
                ....:..||..||..|.:|.:..|   |:||||..||.||.:|||... .|.|||.:|.:.
  Rat   642 ----SGGPLCLSLSALGSVILALVNGAK---HVPYRDHTLTMLLRESLATTSCCTTMIAHISDSP 699

  Fly   496 YNHAETLNTLRYASRAKRIRTK-----------------------PVIKMDPREALILSLKRDIH 537
            .:|||||:|::.|:|..|:|.|                       |.::......::|...|...
  Rat   700 THHAETLSTVQLAARIHRLRRKKGKHASSSSGGESSCEEGRARRPPHLRPFHPRTVVLDPDRSAP 764

  Fly   538 ALQMENDHLKAALNLHHQAAPN------GGPVENLLELQLDRVSSGGGVPVPKVDLQRLPELDGS 596
            ||..:.|:..::    .|:...      ||...:..|| .|.......||:.....:|.|. :|.
  Rat   765 ALSGDPDYSSSS----EQSCDTVIYVGPGGTALSDREL-TDNEGPPDFVPIIPALSRRRPS-EGP 823

  Fly   597 ELAELVKLYMVENESLRQENNHLFTVRETILRDQEIVCRENERLLKKLEDVNKVCV--------- 652
            ..|:..:                              |.....|.::||     |:
  Rat   824 RDADHFR------------------------------CSTFAELQERLE-----CIDGSEGFPGP 853

  Fly   653 ---------------RSPLIP----ARPAISP---------TTGKETPGTEIWTNPEPLQSPP-- 687
                           |.|.:|    .|.|::|         ::|:|||.    :..||.::.|
  Rat   854 QGGSDGAQASPSRGSRKPSLPESTCLRKAVAPSVVTGCPRSSSGQETPR----STSEPSKTGPQG 914

  Fly   688 -------GPDLPIEQRMSENANRR 704
                   .|:.|...:::....||
  Rat   915 DQRVDGTRPEPPAPDKITGGGGRR 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	87/420 (21%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	83/389 (21%)
Kif26a	XP_006240697.1	KISc	364..716	CDD:276812	95/456 (21%)
		KISc	365..725	CDD:214526	98/464 (21%)
		PRK07764	<837..1309	CDD:236090	21/111 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900