DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp54D and Kif12

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_006238315.1	Gene:	Kif12 / 313254	RGDID:	1308487	Length:	648	Species:	Rattus norvegicus

Alignment Length:	631	Identity:	225/631 - (35%)
Similarity:	315/631 - (49%)	Gaps:	118/631 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 EIGSADTLEIVASKSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILE---- 200
            |.||.|. :...:...|.|...||   |.||:||||::..|.|....|.|...|...:.:.
  Rat     3 ERGSPDG-DPARNLEQGPEGSETP---IQVVLRVRPMSTVELRRGEQSALHCSGTRTLQVSPPGG 63

  Fly   201 GNDVGQKRSHNRDSVRVFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKT 265
            |.||            .|.:..|.:...||||:....|:||:.|:.:.|||||.|.:||||||||
  Rat    64 GPDV------------AFRFGAVLDGARTQEDVFRACGVKRLGELALRGFSCTVFTFGQTGSGKT 116

  Fly   266 HTLTGPPDLFVGKPNPKDPRHGLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNPGS 330
            :||||||....|.|.|.. ..|::.|:|.:|...::: .|....|:||::|||||:|.|||:.||
  Rat   117 YTLTGPPPQAEGVPVPPS-LAGIMQRTFTWLLDRMQH-LDSPVTLRASYLEIYNEQVQDLLSQGS 179

  Fly   331 ARKPLAVRWSKKSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI 395
            .| ||.|||| |:.||:||.|..|:|..|:.|:.:|:.|:..|...||.:|..|||||.:||:||
  Rat   180 PR-PLPVRWS-KARGFYVEQLRLVECGSLEALMELLQMGLSRRRSSSHTLNQASSRSHALLTLHI 242

  Fly   396 L--SDQQTDGGVFLSK---HGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLS 455
            .  :.||.. .|.|.:   .||:.||||||||....|.|.|:.:.|||:||:||:.||:|||.|.
  Rat   243 SRPTSQQVP-PVDLGEPPVGGKLCFVDLAGSEKVAATGSRGQLMLEANSINRSLLALGHCISLLL 306

  Fly   456 DSKKRTGHIPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVI 520
            |.:::..|||:|||:|||||||||.|.|||||:|||||:.....|||:||||||||:||.|:|..
  Rat   307 DPQRKQSHIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRITTRPQG 371

  Fly   521 KMDPREALILSLKRDIHALQMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSSGGGVPVPKV 585
            ...|.......::.::..||.||                     ..|.||||::.:
  Rat   372 PKSPAVKPPQQVEAELLQLQEEN---------------------RCLRLQLDQMYT--------- 406

  Fly   586 DLQRLPELDGSELA-------ELVKLYMVENESLRQENNHLFTVRETILRDQEIVCRENERLLKK 643
               :.|.:.|:.:|       .:::.:|:|||.||:|...|.:.|:....:|.::.::...|.::
  Rat   407 ---KAPRVHGARVAWAQRNLYGMLQEFMLENEKLRKEMRQLRSSRDLAQAEQHVLAQQIHELERR 468

  Fly   644 L--------EDVNKVC-----------VRSPL------------------IPARPAISP--TTGK 669
            |        :....||           |..||                  .|.|...:|  ....
  Rat   469 LLLACSLPQQTSATVCPCRMTPAASCHVLPPLCYCYHLCPLCRVSLTHWACPWRECHAPQQVLEP 533

  Fly   670 ETPG-TEIWTNPEPLQSP--PGPDLPIEQRMSENANRRTDTAQKRI 712
            |.|| ......|.|...|  ||...|.::|      ..:|..|.|:
  Rat   534 EAPGHISPSVRPPPWAPPTSPGSAKPPQER------NHSDWTQTRV 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	171/362 (47%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	166/354 (47%)
Kif12	XP_006238315.1	KISc	25..363	CDD:276812	167/357 (47%)
		Kinesin	31..365	CDD:278646	164/350 (47%)
		Kinesin-relat_1	<384..469	CDD:289481	23/117 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352054
Domainoid	1	1.000	272	1.000	Domainoid score	I1738
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7796
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2632
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132313at2759
OrthoFinder	1	1.000	-	-		FOG0012487
OrthoInspector	1	1.000	-	-		oto97844
orthoMCL	1	0.900	-	-		OOG6_106021
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X10430
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760