DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and Kif3b

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001099999.1	Gene:	Kif3b / 296284	RGDID:	1306815	Length:	747	Species:	Rattus norvegicus

Alignment Length:	592	Identity:	183/592 - (30%)
Similarity:	299/592 - (50%)	Gaps:	91/592 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 DNINVVVRVRPLNDKEKRDRHGSTLQFPGN-GQVILEGNDVGQKRSHNRDSVRVFTYNVVFEPGA 228
            :::.||||.||:|.|||...:...:..... |||     .|...:..:.:..:.||::.|::..|
  Rat     8 ESVRVVVRCRPMNGKEKAAAYDKVVDVDVKLGQV-----SVKNPKGTSHEMPKTFTFDAVYDWNA 67

  Fly   229 TQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRHGLIFRSF 293
            .|.::.|.: .:.:::..::||:.|.|.|||||:|||:|:.|    ..|.|.    :.|:|..||
  Rat    68 KQFELYDET-FRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEG----VRGDPE----KRGVIPNSF 123

  Fly   294 LYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSGGFFVENLFTVDCEE 358
            .::|..|...::..|:::||::|||.|.:.|||:....:: |.:: .:...|.:|::|.:...:.
  Rat   124 DHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKR-LELK-ERPDTGVYVKDLSSFVTKS 186

  Fly   359 LDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI-LSDQQTDGGVFLSKH---GKINFVDLA 419
            :.::..|:..|.:||:||:..||:||||||.|..:.: .|:...||    ..|   ||:|.||||
  Rat   187 VKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITVECSEVGLDG----ENHIRVGKLNLVDLA 247

  Fly   420 GSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAGNGV 484
            |||...||.::|:.|:||..||.||..||..||:|.|.|  :.|||||||:||:||.|||.||..
  Rat   248 GSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGK--STHIPYRDSKLTRLLQDSLGGNAK 310

  Fly   485 TLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRDIHALQMENDHLKAA 549
            |:|:|.|.||.||..|||.|||||:|||.|:.||.:..||::||:...:.:|..|:.:.:.....
  Rat   311 TVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIG 375

  Fly   550 LNLHHQAAPNGGPVENLLELQLDRVSSGGGVPVPKVDLQRLPELDGSELAELVKLYMVENESLRQ 614
            .....:....||             .||||....:.:.:. .|.:|.:          :::..|:
  Rat   376 RRKRREKRREGG-------------GSGGGGEEEEEEGEE-GEEEGDD----------KDDYWRE 416

  Fly   615 ENNHLFTVRETILRDQEIVCRENERLL----KKLEDVNKVCVRSPLIPARPAISPTTGKETPGTE 675
            :...|...:..|:.|..:|..|..|||    ||:||:.:....:.::.|:  |.....|...|
  Rat   417 QQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAK--IKAMESKLLVG-- 477

  Fly   676 IWTNPEPLQSPPGPDLPIEQRMSENANRRTDTAQKRIDQKR--IAKNILIMANAFRKPDSDITKE 738
                                  .:|....|:..||.::|||  ||:.        ::.:.:|.::
  Rat   478 ----------------------GKNIVDHTNEQQKILEQKRQEIAEQ--------KRREREIQQQ 512

  Fly   739 LNLNPEE 745
            :....||
  Rat   513 MESRDEE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	140/358 (39%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	135/350 (39%)
Kif3b	NP_001099999.1	KISc_KIF3	8..340	CDD:276822	137/353 (39%)
Kif3b	NP_001099999.1	Smc	<352..>614	CDD:224117	41/226 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810