DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and Kif26b

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001155137.1	Gene:	Kif26b / 269152	MGIID:	2447076	Length:	2112	Species:	Mus musculus

Alignment Length:	809	Identity:	176/809 - (21%)
Similarity:	283/809 - (34%)	Gaps:	252/809 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ASSVPHLNSSGGSSADSAGTSGSRRGRAPVAGS---RGRKTPSTTSTGQSQRQSSGSSSSMPRSR 99
            |||||....|..:|..|.|||        ||.|   |..:..:.:|..:..|.|:.|.:..|...
Mouse   361 ASSVPAPQGSCVASETSTGTS--------VAASFFARAAQKLNLSSKKKKHRPSTPSVAEAPLFA 417

  Fly   100 SLTNGMRRLSPQKGTGSSGGTGGGGGSSRNTPYFLRSRENEI----GSADTLEIVASKSTGSEEC 160
            :..:|:.:.||...                .|..||: .|::    |......::...||.:.:.
Mouse   418 TSFSGILQTSPPPA----------------PPCLLRA-VNKVKDTPGMGKVKVMLRICSTSARDT 465

  Fly   161 STPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRVFTYNVVFE 225
            |.....:.|..|.:.:           ||..|    :...|.:..|||| ::...::|.::.||.
Mouse   466 SESSSFLKVDPRKKQI-----------TLYDP----LTCGGQNAFQKRS-SQVPPKMFAFDAVFP 514

  Fly   226 PGATQEDILDYSG-IKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRHGLI 289
            ..|:|.::.  :| :..:|:..:.|.....||:|....||::|:.|..|..        ...|:|
Mouse   515 QDASQAEVC--AGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSM--------QNLGII 569

  Fly   290 FRSFLYLFQLIKNRKD---VNYVLKASFMEIY--NERVIDLL----------------------- 326
            ..:..:||:||..||:   ..:.::.|.:|::  .|.:.|||
Mouse   570 PCAISWLFKLINERKEKTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPI 634

  Fly   327 ------NPGSARKPLAVRWSKKSGGFFVENLFT------VDCEELDDLLAVLEEGMRNRAVGSHA 379
                  |....|.|.|     :...||::....      .||:|
Mouse   635 CGTQLQNQSELRAPTA-----EKAAFFLDAAIASRRSNQQDCDE--------------------- 673

  Fly   380 MNDHSSRSHTILTVHILS---DQQTDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNIN 441
             :||.: ||.:.|:||..   ::...||: .....:::.:|| ||  ..|.:|  |..|..:.:.
Mouse   674 -DDHRN-SHMLFTLHIYQYRMEKSGKGGM-SGGRSRLHLIDL-GS--CVKALS--KNREGGSGLC 730

  Fly   442 KSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLLADSLAG-NGVTLMIACVSPAHYNHAETLNTL 505
            .||..||..|.:|.:..|   ||||::|:||.||.:||.. |..|.|||.:|.|..::||||:|:
Mouse   731 LSLSALGNVILALVNGSK---HIPYKESKLTMLLRESLGNVNCRTTMIAHISAAASSYAETLSTI 792

  Fly   506 RYASRAKRIRTKPVIKMDPREALILSLK--RDIHALQMENDHLKAALNLHHQAAPNGGPVENLLE 568
            :.|||..|::.|.............|.:  |.....|:...|.:|.::.....||        |.
Mouse   793 QIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHARAPVDPEFPLAP--------LS 849

  Fly   569 LQLDRVSSGGGVPVPKVDLQRLPELDGSELAELVKLYMVENESLRQENNHLFTVRETILRDQEIV 633
            ...|..||                   ||.:....:|:..|              .|.|.|:|:.
Mouse   850 SDPDYSSS-------------------SEQSCDTVIYIGPN--------------GTALSDKELT 881

  Fly   634 CRENERLLKKLEDVNKVCVRSPLIPARPAISPTTGKETPG------------------------- 673
            ..|..               ...:|..||:..|.|...||
Mouse   882 DNEGP---------------PDFVPIVPALQKTRGDSRPGEAAEAAASKSERDCLKCNTFAELQE 931

  Fly   674 ------------------TEIWTNPE------PLQSPPGPDLPIEQRMSENANRRTDTAQKRIDQ 714
                              ..|...||      ||....|||.|.|....:|.:......::...:
Mouse   932 RLDCIDGSEEPSKFPFEELPIQFGPEQAGRCAPLSQAVGPDTPSESEKEDNGSDNGQLTEREGTE 996

  Fly   715 KRIAKNILIMANAFRKPDSDITKELNLNP 743
            ...:|     |...|.|...:|:..:.:|
Mouse   997 LPASK-----AQRNRSPAPTVTRSSSPSP 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	101/398 (25%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	99/390 (25%)
Kif26b	NP_001155137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..286
		KISc	450..798	CDD:276812	101/410 (25%)
		KISc	451..798	CDD:214526	101/409 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..859		11/80 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..917		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	955..1165		16/71 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1405..1501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1569..1649
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1734
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1748..1801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1899..1971
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900