Protein Alignment Klp54D and KIF6

DIOPT Version :9

• Sequence 1: NP_001303355.1
• Gene: Klp54D / 47216
• FlyBaseID: FBgn0263076
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: XP_005248961.1
• Gene: KIF6 / 221458
• HGNCID: 21202
• Length: 842
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 151/531 - (28%)
• Similarity: 236/531 - (44%)
• Gaps: 109/531 - (20%)

  Fly   164 EDNINVVVRVRP-----------LNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRV 217
            :..|.:..||:|           :::.||        ..| :.::||. .|:.....:|:.....
Human     3 KQTIQIFARVKPPVRKHQQGIYSIDEDEK--------LIP-SLEIILP-RDLADGFVNNKRESYK 57

  Fly   218 FTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPK 282
            |.:..:|:..|.||.:.: :..|.:....:.|::.|.|.|||||||||.|:||..:.:..:
Human    58 FKFQRIFDQDANQETVFE-NIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDR---- 117

  Fly   283 DPRHGLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARK-----PLAVRWSKK 342
                |:|.|:..|:|:.::......|....|::|||||...|||:|.....     |........
Human   118 ----GIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDP 178

  Fly   343 SGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGVFL 407
            .....::||........::.|.:|..|..||.:....||..|:|||.|.|:|:.|.:.....|
Human   179 DQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATV-- 241

  Fly   408 SKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLT 472
             :|.|::.|||||||...||...|..|.||..||.||..|...|.:||:  |...|||||:|.:|
Human   242 -RHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIALSE--KHRSHIPYRNSMMT 303

  Fly   473 KLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVI--KMDPREALILSLKRD 535
            .:|.|||.||.:|.|||.:|....|..|:::|.|:|.|...|:.:.|:  :::||    |.:||
Human   304 SVLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAVLNEEINPR----LVIKR- 363

  Fly   536 IHALQMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSSGGGVPVPKVDLQRLPELDGSELAE 600
               ||.|...||                        |.::...|.       ||...|..:||.:
Human   364 ---LQKEIQELK------------------------DELAMVTGE-------QRTEALTEAELLQ 394

  Fly   601 LVKL---YMVENES---------LRQENNHLFTVRETILRDQEIV-------------CRE--NE 638
            |.||   ::.:.:|         :|:. :|.|...:.:|.|::|:             |:|  .|
Human   395 LEKLITSFLEDQDSDSRLEVGADMRKV-HHCFHHLKKLLNDKKILENNTVSSESKDQDCQEPLKE 458

  Fly   639 RLLKKLEDVNK 649
            ...:||.|:.|
Human   459 EEYRKLRDILK 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	116/369 (31%)
		KISc	166..512	CDD:276812	115/361 (32%)
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	115/361 (32%)
		Kinesin	11..345	CDD:278646	114/357 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810