DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and Kif6

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_006244542.1	Gene:	Kif6 / 171291	RGDID:	621070	Length:	802	Species:	Rattus norvegicus

Alignment Length:	693	Identity:	188/693 - (27%)
Similarity:	288/693 - (41%)	Gaps:	142/693 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 EDNINVVVRVRPLNDKEKR--------DRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRVFTY 220
            :..|.:..||:|...|:::        ::..|:|:       |:...|:.....:|:.....|.:
  Rat     3 KQTIQIFARVKPSVRKQQQGIYSIDEDEKLASSLE-------IVLPRDLADGFVNNKRESYKFKF 60

  Fly   221 NVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPR 285
            ..:|:..|.||.|.:... |.:.|..:.|::.|.|.|||||||||.|:||..:.:..:
  Rat    61 QRIFDQEAKQEIIFEIIA-KPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDR------- 117

  Fly   286 HGLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNP-GSARK----PLAVRWSKKSGG 345
             |:|.|:..|:|:.::......|....|::|||||...|||:| ..|.|    |...........
  Rat   118 -GIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQN 181

  Fly   346 FFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGVFLSKH 410
            ..::||........::.|.:|..|..||.:....||..|:|||.|.|||:.|.:.....|   :|
  Rat   182 IHLKNLSLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSATV---RH 243

  Fly   411 GKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTKLL 475
            .|::.|||||||...||...|..|.||..||.||..|...|.:||: |.|| |||||:|.:|.:|
  Rat   244 AKLHLVDLAGSERVSKTGVGGLLLTEAKYINLSLHYLEQVIIALSE-KHRT-HIPYRNSMMTSVL 306

  Fly   476 ADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVI--KMDPREALILSLKRDIHA 538
            .|||.||.:|.|||.:|....|..|:::|.|:|.|...|:.:.::  ::|||..::        .
  Rat   307 RDSLGGNCMTTMIATLSLEKRNIDESISTCRFAQRVALIKNEAILNEEIDPRLMIV--------R 363

  Fly   539 LQMENDHLKAALNLHHQAAPNGGP-VENLLE---LQLDRVSSG------------GGVPVPKV-- 585
            ||.|...|||.|     |...|.. .|.|.|   |||:::.:.            .|..:.|:
  Rat   364 LQKEIADLKAEL-----AMVTGEQRTEALTEAELLQLEKLIASFVEDQDPESRLEVGADLRKIHY 423

  Fly   586 ----------DLQRLPELDGSELAELVKLYMVENESLRQENNHLFTVRETIL--RDQEIVCREN- 637
                      |.:.|...|.||..    ......|.::.|.   :|...::|  ||.||....|
  Rat   424 CFHHFKKLLNDKKTLENTDSSEST----TQQACQEPVKDEE---YTKLRSLLKQRDNEINILVNM 481

  Fly   638 -ERLLKKLED------VNKVCVR----SPLIPARPAISPTTG----KETPGTEIWTNPEPL---- 683
             ::..||.:|      ..|...|    ||.|...||...|:.    .:|....::.:...|
  Rat   482 LKKEKKKTQDALQYSSTEKSEARPPPNSPFIAGSPAGQRTSFSSSLSQTQDLSVYRHRSSLLHKK 546

  Fly   684 ------------------QSPPGPDLPIE-------QRMSE---------NANRRTDTAQKRIDQ 714
                              :......:.||       ||.||         .|..:....::.|.|
  Rat   547 TGMREEMSLGRQEAFEIFKRDHADSVTIEDNKQVLKQRFSEAKALGESINEARSKIGQLKEAISQ 611

  Fly   715 KRIAKNILIMANAFRKPDSDITKELNLNP--EEAHAKQSTEFM 755
            :.:.:..|.:|.:...|.:...:|..|..  ||..::..|.||
  Rat   612 RHLQQVALGIAESMAPPSTPDPQEQKLRAQLEEEKSRYKTTFM 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	122/366 (33%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	121/358 (34%)
Kif6	XP_006244542.1	KISc_KIF9_like	5..343	CDD:276826	121/358 (34%)
Kif6	XP_006244542.1	Kinesin	28..345	CDD:278646	116/337 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900