DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and Kif9

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_006512005.1	Gene:	Kif9 / 16578	MGIID:	1098237	Length:	839	Species:	Mus musculus

Alignment Length:	715	Identity:	181/715 - (25%)
Similarity:	322/715 - (45%)	Gaps:	158/715 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KTPSTTSTGQSQRQSSGSSSSMPRSRSLTNGMRRLSPQKGTGSSGGTGGGGGSSRNTPYFLRSRE 138
            :.||:..:      |||.|:..|..|.:::|...::..|           .|:.:....|:|.|.
Mouse    17 RAPSSCCS------SSGRSTRAPLPREVSSGHEPVALAK-----------MGTRKKVQAFVRVRP 64

  Fly   139 NEIGSADTLEIVASKSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGND 203
            .:             ....|.....|||.::.:.::      |..|.|.......:....|:|
Mouse    65 TD-------------DFAHEMIKYGEDNKSIDIHLK------KDTRRGVVNNQQTDWSFKLDG-- 108

  Fly   204 VGQKRSHNRDSVRVFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTL 268
                ..||.      :.::|:|..|           |..:...::|::.|..||||||:|||:|:
Mouse   109 ----VLHNA------SQDLVYETVA-----------KDAVSQALDGYNGTIMCYGQTGAGKTYTM 152

  Fly   269 TGPPDLFVGKPNPKDPRH-GLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNP---- 328
            ||..:.:         :| |::.|:...:|::|:.|......::.|::|||||.:.|||:.
Mouse   153 TGATENY---------KHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNENLFDLLSTLPYV 208

  Fly   329 GSARKPLAVRWSKKSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTV 393
            |.:..|:.:  .:...|.|::.|......:.:|..::|.||..||.:.||.||.:|||||.|.|:
Mouse   209 GPSVTPMTI--VENPQGIFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTI 271

  Fly   394 HI------LSDQQTDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCIS 452
            ::      |||::     :::  .|||.|||||||...||.|||:.|:||..|||||..|...|.
Mouse   272 YMEAHSRTLSDEK-----YIT--SKINLVDLAGSERLSKTGSEGRVLKEATYINKSLSFLEQAII 329

  Fly   453 SLSDSKKRTGHIPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHA----ETLNTLRYASRAKR 513
            :|.|..:  .|:|:|.|:||..|.|||.||...:::..:    |..|    |||::||:|||.|.
Mouse   330 ALGDQNR--DHVPFRQSKLTHALKDSLGGNCNMVLVTNI----YGEAAQLDETLSSLRFASRMKL 388

  Fly   514 IRTKPVI--KMDPREALILSLKRDIHALQMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSS 576
            :.|:|.|  |.| .|.::.:|::::..|:.|   |....:|.::...|..|::   |:|:..::|
Mouse   389 VTTEPAINEKYD-AERMVKNLEKELALLKQE---LAIHDSLSNRTLVNYDPMD---EIQIAEINS 446

  Fly   577 GGGVPVPKVDLQR-----LPELDGSELAELVKLYMVENESLRQENNHLFTVRETILRDQEIVCRE 636
                     .::|     |.|:|...|.::.:::......|.|:...   |...:.|...::.:.
Mouse   447 ---------QVRRYLEGTLDEIDIINLRQIQEVFNQFRVVLSQQEQE---VESALRRKYTLIDKN 499

  Fly   637 NERLLKKLEDVNKVCVRSPLIPARP-------AISPTTGKETPGTEIWTNPEPLQSPPGPDLPIE 694
            :...:..::.|..:.:...|: ..|       .::|.:.|  ||.:    |:..::|       :
Mouse   500 DFAAISAVQKVGLMDIEGNLV-GEPDGQSFGLGVAPFSVK--PGKK----PKTKKTP-------K 550

  Fly   695 QRMSENANRR---TDTAQKRIDQKRIAKNILIMANAFRKPDSDITKELNLNPEEAHAKQSTEFMP 756
            .:.|.:|.:.   :..:.|..|...|:|..||       |.|   |:.:|....|..::::...|
Mouse   551 DQFSSSARKEGASSPVSGKDFDVASISKTQLI-------PSS---KDGDLKDMLARERETSSIEP 605

Fly 757 756
Mouse 606 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	118/368 (32%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	115/360 (32%)
Kif9	XP_006512005.1	KISc_KIF9_like	55..387	CDD:276826	121/397 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900