Protein Alignment Klp54D and Kif3a

DIOPT Version :10

• Sequence 1: NP_001303355.1
• Gene: Klp54D / 47216
• FlyBaseID: FBgn0263076
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Alignment Length: 639
• Identity: 193/639 - (30%)
• Similarity: 305/639 - (47%)
• Gaps: 115/639 - (17%)

  Fly   152 SKSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVR 216
            :||...|.|    ||:.||||.||||::||...:...:....     :.|.....|...:.:..:
Mouse     4 NKSEKPESC----DNVKVVVRCRPLNEREKSMCYRQAVSVDE-----MRGTITVHKTDSSNEPPK 59

  Fly   217 VFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTG---PPDLFVGK 278
            .||::.||.|.:.|.|:.:.:. :.||:..:||::.|.|.|||||:|||.|:.|   .|.|
Mouse    60 TFTFDTVFGPESKQLDVYNLTA-RPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGL---- 119

  Fly   279 PNPKDPRHGLIFRSFLYLF-QLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKK 342
                   .|:|..||.::| .:.|...|..::::.|::|||||.|.|||.....:: |.|: .:.
Mouse   120 -------RGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQR-LEVK-ERP 175

  Fly   343 SGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI-LSDQQTDGGVF 406
            ..|.::::|........||:..::..|.:||:||:..||:||||||.|.|:.| .|::..||.:.
Mouse   176 DVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMH 240

  Fly   407 LSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQL 471
            : :.||::.|||||||...||.:.|:.|:||..||.||..||..||:|.|.|  :.|:|||:|:|
Mouse   241 V-RMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGK--STHVPYRNSKL 302

  Fly   472 TKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRDI 536
            |:||.|||.||..|:|.|.:.||.||:.||::|||||:|||.|:.|..|..||::||:...:::|
Mouse   303 TRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEI 367

  Fly   537 HAL-------------------------QMENDHLKAALNLHHQAAPNGGPVENLLELQLD---- 572
            ..|                         ::..|..|........::.:.....:::|..||
Mouse   368 EELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLP 432

  Fly   573 ------RVSSGGGVPVPKVDLQRLPELDGSELAELVKLYMVENESLRQENNHLFTVRETILRDQE 631
                  :||     |...|::|  .::|....|...||.| |.|...:....|....:.:|:.|:
Mouse   433 HQAGKKKVS-----PDKMVEMQ--AKIDEERKALETKLDM-EEEERNKARAELERREKDLLKAQQ 489

  Fly   632 IVCRENERLLKKLEDVNKVCVRSPLIPARPAISPTTGKETPGTEIWTNPEPLQSPPGPDLPIEQR 696
                |::.||:||..:.|..:                  ..|.::....|..:.     |..|..
Mouse   490 ----EHQSLLEKLSALEKKVI------------------VGGVDLLAKAEEQEK-----LLEESN 527

  Fly   697 MS-ENANRRTDTAQKRIDQKRIAKNILIMANAFRKPDSDITKELNLNPEEAHAK 749
            |. |...||.:..:|.:::|             .:...||.::.....|||..|
Mouse   528 MELEERRRRAEQLRKELEEK-------------EQERLDIEEKYTSLQEEAQGK 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	139/358 (39%)
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	138/353 (39%)
		Smc	<450..>614	CDD:440809	32/160 (20%)