DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp54D and KIF20A

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_005724.1	Gene:	KIF20A / 10112	HGNCID:	9787	Length:	890	Species:	Homo sapiens

Alignment Length:	756	Identity:	179/756 - (23%)
Similarity:	307/756 - (40%)	Gaps:	197/756 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 TPYFLRSRENEIGSADTLEI-----VASKSTGSEECSTPEDN---INVVVRVRPL--NDKEKRDR 184
            :|.| .|...::||.....:     |.|.|...::....||:   :.|.:|||||  ::.|:::.
Human    21 SPMF-ESTAADLGSVVRKNLLSDCSVVSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQED 84

  Fly   185 HGS---------TLQFPGNGQVILEGNDVGQKRSHNRDSVRVFTYNVVFEPGATQEDILDYSGIK 240
            .|.         .||.| .....|:.|:.|..::.:|     ||::.:|.|...|....:.: :|
Human    85 QGCVRIENVETLVLQAP-KDSFALKSNERGIGQATHR-----FTFSQIFGPEVGQASFFNLT-VK 142

  Fly   241 RIIEMGIEGFSCTAFCYGQTGSGKTHTLTG--------PPDLFV------GKPNPKDPRHGLIFR 291
            .:::..::|.:...:.||.|.||||||:.|        |..|.:      |:.:|......|:..
Human   143 EMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDGGILPRSLALIFNSLQGQLHPTPDLKPLLSN 207

  Fly   292 SFLYLFQ-------------------------------LIKNR---------------------- 303
            ..::|..                               .|::|
Human   208 EVIWLDSKQIRQEEMKKLSLLNGGLQEEELSTSLKRSVYIESRIGTSTSFDSGIAGLSSISQCTS 272

  Fly   304 ----------------------KDVNYVLKASFMEIYNERVIDLLNPGS-ARKPLAVRWSK-KSG 344
                                  .::.:.:..||.|||||.:.|||.|.| .||...:|..: ::|
Human   273 SSQLDETSHRWAQPDTAPLPVPANIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNG 337

  Fly   345 GFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGVFLSK 409
            ..:|::|..:..::.::...:|:.|.:|::..|..:|.:|||||:|.::.|| ..|.:|.: :.|
Human   338 NPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTHLNQNSSRSHSIFSIRIL-HLQGEGDI-VPK 400

  Fly   410 HGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSL---SDSKKRTGHIPYRDSQL 471
            ..:::..||||||..|...| |:.|:||.|||.||..||.||::|   ..::.:...:|:|||:|
Human   401 ISELSLCDLAGSERCKDQKS-GERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKL 464

  Fly   472 TKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRDI 536
            |::......|.|.:.||..|:|....:.|||:..::::.|.::...|     |.:....||...|
Human   465 TRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSAIASQLVHAP-----PMQLGFPSLHSFI 524

  Fly   537 --HALQMENDHLKAALNLHHQAAPNGGPVENLLELQLDRVSSGGGVPVPKVDLQRLPELDGSELA 599
              |:||:.....|.|      .|..|  :::.:|.:.| :|..|...:.:| ::.:..|...|..
Human   525 KEHSLQVSPSLEKGA------KADTG--LDDDIENEAD-ISMYGKEELLQV-VEAMKTLLLKERQ 579

  Fly   600 ELVKL----------YMVENESLRQE--NNHLFTVRETILRDQEIVCRENERLLKK------LED 646
            |.::|          .|||....|::  :.||.|.:|.:    |.:..|...:||:      .|:
Human   580 EKLQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKELL----EEMYEEKLNILKESLTSFYQEE 640

  Fly   647 VNKVCVRSPLIPARPAISPTTGKETPGTEIWTNPEPLQSPPGPDLPIEQRMSENANRRTD--TAQ 709
            :.:   |...|....|:                   ||......:..:|..||.|.||:.  .|.
Human   641 IQE---RDEKIEELEAL-------------------LQEARQQSVAHQQSGSELALRRSQRLAAS 683

  Fly   710 KRIDQKRIAKNILIMANAFRKPDSDITKELNLNPEEAHAKQ 750
            ....|.:..|..|....|          |||...||.|..|
Human   684 ASTQQLQEVKAKLQQCKA----------ELNSTTEELHKYQ 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	113/461 (25%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	111/453 (25%)
KIF20A	NP_005724.1	KISc_KIF23_like	63..505	CDD:276819	111/451 (25%)
		SMC_N	<547..>795	CDD:330553	45/206 (22%)
		Globular. /evidence=ECO:0000255	763..890
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..865
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910