DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp54D and kif26a

DIOPT Version :9

Sequence 1:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_004917245.2	Gene:	kif26a / 100491850	XenbaseID:	XB-GENE-6051360	Length:	2010	Species:	Xenopus tropicalis

Alignment Length:	1024	Identity:	216/1024 - (21%)
Similarity:	361/1024 - (35%)	Gaps:	369/1024 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STVP--CPRDILVLSKQSTPYPAFAHSVASTQVTMVRRASSVPHLNSSGGSSADSAGTS-----G 59
            |.:|  .|::::.:|.|.             ::.|:......|    ||.|:....||.     |
Frog   189 SVIPRLSPQNMITVSPQK-------------ELLMIAGQVGRP----SGKSTNLFHGTEKKKGLG 236

  Fly    60 SRRGRAPVAGSRGRKTPSTTSTG--------QSQRQSSG-----------SSSSMPRSRSLTNGM 105
            ..:|.:.:..|..:.|.:.:|.|        |:|:...|           .|:.:|.:.|:..|.
Frog   237 WGQGGSSLPNSSVQVTVAPSSLGGALSSVTIQAQQYLEGMWSISRVNSFLPSACLPDAPSMDGGR 301

  Fly   106 RRLSPQKGTGSSGG----TGG-----------GGGSSRNTPYFLRSRENEIGSADTLEIVASK-- 153
            ...:.:..:|.|..    ||.           ..|:|....:|:|       :|..|.:.:.:
Frog   302 ENQNTEISSGPSNNQQSVTGSTQSFFAPAGAESAGTSAAASFFIR-------AAQKLNLSSKRKK 359

  Fly   154 -----------STGS-------EECSTP------------EDN-----INVVVRVRPLNDKEKRD 183
                       ||.|       :.|..|            :||     :.::||:.|....:...
Frog   360 YHPPLPHSQEYSTYSTNFSGILQLCPPPAPPCLMRAVSKIKDNPGIGKVKIMVRICPFQGPQNTS 424

  Fly   184 RHGSTLQF-PGNGQVIL-EGNDVGQKRSHNRDSV----RVFTYNVVFEPGATQEDILDYSG-IKR 241
            ...|.|:. |...||.| :.:..|...|.:|.:|    ::|.::.||...|:|.::.  || :..
Frog   425 ESMSFLKVDPRKKQVTLYDPSTCGPSVSVHRRAVVAVPKMFAFDSVFPQDASQAEVC--SGTVAE 487

  Fly   242 IIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRH---GLIFRSFLYLFQLIKNR 303
            :|:..:.|.....||:|....||::|:.|           ||...   |:|..:..:||:||..|
Frog   488 VIQSVVNGADGCIFCFGHVRLGKSYTMIG-----------KDASTQSLGIIPCAISWLFKLINER 541

  Fly   304 KD---VNYVLKASFMEIY--NERVIDLL-----------------------------NPGSARKP 334
            |:   ..:.::.|.:||:  :|.:.|||                             |....|.|
Frog   542 KEKTGTRFSIRVSAVEIFGKDENLKDLLAEEATGSLQDGQSPGVYLREDPICGTQLQNQSELRAP 606

  Fly   335 LAVRWSKKSGGFF-----VENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVH 394
            .|    :|:..|.     ..:....||:         ||..||              ||.:.|:|
Frog   607 TA----EKAAHFLDAALAARSTSRPDCD---------EEERRN--------------SHMLFTLH 644

  Fly   395 ILS---DQQTDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSD 456
            |..   ::...||: .....:::.:||...|   |.:|  |:.:....:..||..||..|.:|.:
Frog   645 IYQYRMEKSGKGGM-SGGRSRLHLIDLGSCE---KVLS--KSRDGCGGLCLSLTALGNVILALVN 703

  Fly   457 SKKRTGHIPYRDSQLTKLLADSLAG-NGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTK--- 517
            ..|   |||||||:||.||.:||.. |..|.|||.:|.:..|:.|||:|::.|||..|::.|
Frog   704 GAK---HIPYRDSKLTMLLQESLGNINCRTTMIAHISDSPANYQETLSTVQLASRIHRMKKKKSK 765

  Fly   518 --------------------PVIKMDPREALILSLKRDIHALQMEND-----HLKAALNLHHQAA 557
                                |.|:  |.....:.|..|...|...:|     ..:.:.:......
Frog   766 YASSSSGGESSCEEGRVRRPPHIR--PFHQRTVVLDPDFPTLGFHSDPDYSSSSEQSCDTVIYVG 828

  Fly   558 PNG------------GPVE------NLLELQ-LDRVSSGGGVPVPKVD------------LQRLP 591
            |||            ||.|      :||:.: .|.:||     :...|            .:||.
Frog   829 PNGAALSDKELTDNEGPPEFVPIIPSLLKKRSKDNLSS-----IRSSDNDHLKCNTFAELQERLE 888

  Fly   592 ELDGSELAELVKLYMVE------NESLRQENNHLFTVRETIL----------------RDQEIV- 633
            .:||||  |..:..:.|      |:::..|:|...|..:|:|                :.|.|:
Frog   889 CIDGSE--EPARFLIEEPVAAHCNKAMNYEDNVHSTKEKTLLSGICKRPGFQDMVSPKKGQNIII 951

  Fly   634 ------------------CRENERLLKKLEDVNKVCV----RSPLIPARPAISPTTGK--ETP-- 672
                              ..|:.:...|.|:|...|:    :..::..:..::|:..|  |.|
Frog   952 STAFPPNISDSETNAPQSAHEHPQQHAKAENVKPECISDGNQVTIMDLQKTLAPSVCKAQEIPKG 1016

  Fly   673 GTEIWTNPEPLQS---------PPGPDLPIEQRMSENANRRTD----TAQKRIDQKRIAKNIL-- 722
            .|||....:.|.:         |||.    :...|.|...||.    :..|..|:.::..:.|
Frog  1017 ATEISVKEKALMARRHLPSPAPPPGS----QSCSSNNVGVRTPPIGMSKLKCQDKHKLVSSTLPV 1077

  Fly   723 -------------------IMANAFRKPDSDI-------TKELNLNPEE 745
                               :..|.|   |.||       .|.:.||.|:
Frog  1078 GISTPKQPGPIEVRRFRSAVKTNGF---DRDILTTTVTLQKPVELNGED 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	109/434 (25%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	106/403 (26%)
kif26a	XP_004917245.2	KISc	407..757	CDD:276812	105/398 (26%)
kif26a	XP_004917245.2	DUF5401	<1868..>1975	CDD:375164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000