Protein Alignment ATM and tel1

DIOPT Version :10

• Sequence 1: NP_000042.3
• Gene: ATM / 472
• HGNCID: 795
• Length: 3056
• Species: Homo sapiens
• Sequence 2: NP_588126.1
• Gene: tel1 / 2539209
• PomBaseID: SPCC23B6.03C
• Length: 2812
• Species: Schizosaccharomyces pombe
• Alignment Length: 3548
• Identity: 757/3548 - (21%)
• Similarity: 1287/3548 - (36%)
• Gaps: 1237/3548 - (34%)

Human     5 LNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNW-DAVFRFLQKYI 68
            |||::   .:|...:...|...::..:..|            ..|:.|..||. ||:  .::|.|
pombe     4 LNDIV---NKLSSSKIKTRSDALQNLRSYI------------IYSRNGNSLNQEDAL--IIEKAI 51

Human    69 QKETECLRIAKPNVSAS------TQASRQKKMQEISSLVKYFIKCANR-----RAPRLKCQELLN 122
            ::..|    .:..:||:      ::||:::|:|:||.|::   .|...     |.|.:..  ||:
pombe    52 KRAFE----LEWQISANHGKRQISKASQEQKLQDISYLLR---TCVESYILLFREPHILA--LLD 107

Human   123 YIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLV 187
            .|:... .::||:|....|.|                        ||...||.|..|..:|.:
pombe   108 IILRHT-FTANGSICEVVCLN------------------------FSKALRLLLSHSPHLHHL-- 145

Human   188 ARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVC 252
                                :|.|:.|....|.:.                 ::.|::.....|.
pombe   146 --------------------RFSDWQSLVSYCCQA-----------------IEKLSIAEETYVS 173

Human   253 ELGDEILPTLLY----IWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILY 313
            :..:|.:....|    ||..|.: ..:|:.::||    ||:                  .|| |.
pombe   174 DSEEEPISQKNYQEISIWKSHDV-IRVKQEVVEL----IYV------------------MRS-LV 214

Human   314 NLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESS 378
            ..|...:|.:|                  |.|::.. :.....:.|:|.:
pombe   215 QWYAAPINFVS------------------EQLLKFF-EFFFYAYTEETDA--------------- 245

Human   379 DYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCE--LSPLLMILSQ 441
                                ||          |.||...||.:   .::|||.  .:.:::::.:
pombe   246 --------------------HL----------PALQCLFQLCA---YAIPNCNDYSASVVLLVFK 277

Human   442 LLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFG 506
            :|......:|....|:.:..:|:.....||.|:         |:....|  |..:.:.:.:..|.
pombe   278 ILINSDKWKRLDLRLQLIQCLAISYPLWSNSET---------WDPHRSI--RSFNLDLLNSSFFS 331

Human   507 LLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFS 571
            |             :.|...|                              |...::...|..|.
pombe   332 L-------------KNFLNFF------------------------------GKRSSLSLANFRFH 353

Human   572 L---KESIMKWL-----LFYQLEGDLENSTEVPPILHSNFPHLVLEK-ILVSLTMKNCKAAMNFF 627
            .   |.:|.|..     ||:.|.   .||     ...|.|.:..|.| ||:..|:.:..:.
pombe   354 TVEPKNNIAKLYDPRLHLFFSLR---HNS-----FFESYFIYFFLAKLILLKKTVLSLAST---- 406

Human   628 QSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDR 692
                    .|.:|::.:.|::|||.||.....:               |:..||:      .|..
pombe   407 --------EQANKKQKTCSQIEELLLQAELANI---------------SASSFSL------QLMV 442

Human   693 CLLGLSEQLLNN-------YSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAK 750
            .:..:|:.|.|:       .|...|..:..::.....:....||        .:||.|.|....|
pombe   443 IITAISDNLTNDDLLSIQKMSLNFTEKKNELQSWSFFILFNICY--------NKAYSSMLTTSCK 499

Human   751 SLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDI 815
                              :|....:.|.::               |.:.|....::||  ..|..
pombe   500 ------------------KEILAAASRGLL---------------NSVTSPVCYQILT--YFNMY 529

Human   816 ADIC-KSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTI 879
            ..:| .|:..|||:.|                         .|||||
pombe   530 RPLCFASIFPFIKQQF-------------------------ILFNDY------------------ 551

Human   880 GAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTL---EPTKS 941
               :|:                              :|:.|.|..:.|.:|::.:..   ...||
pombe   552 ---SPM------------------------------LSYEAIDYWKSLYILLNENLFVGQSSFKS 583

Human   942 LHL-----HMYLMLLKELPGEEYPLP----------MEDVLELL--KPLS------NVCSLYRRD 983
            :.|     |:|.:..||  ||   ||          :.|:|.::  :|||      .:.|.:.|:
pombe   584 VFLKWLKWHLYHLFSKE--GE---LPFFSFTDSSIIIFDLLMMIFYRPLSLSYITTEIRSPFERN 643

Human   984 -------------------QDVCKTIL--------NHVL------HVVKNLGQSNMD--SENTRD 1013
                               .::||...        ||.:      :|:|.| :|::|  |..:.|
pombe   644 LFHLKEAWSPVTLRFPYTTDEICKQSTEGCYPFNSNHTIDCDSLQNVIKML-ESSIDEISSASYD 707

Human  1014 AQGQFLTVIGAFWHLTKERK-----YIFSVRMALVNCLKTLLEADPYSKWAILNVMGKD------ 1067
            ..           .|.||..     .|||....|...|...::     |..|.||...:
pombe   708 KD-----------ELDKETPSFEAVMIFSQISFLCGFLNCFIQ-----KKGIHNVTPNNLVIFKN 756

Human  1068 -FPVNEVFTQFLADNH------------------HQVRMLAAESINRLFQDTKGDSSRLLKALPL 1113
             ||  ||.: |:..||                  .:.:.|..|..:.|.:.|....|..||.|.|
pombe   757 LFP--EVLS-FVKSNHSYDPIINCISTNLQFTISDEPKHLRYEIGSDLIRSTHFRDSNPLKTLVL 818

Human  1114 KLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCK 1178
            .:...|.:|.::|.|    |..|        ||.:::                  |::.::.
pombe   819 YIMDMASKNVFIKPQ----EFDH--------DEYFSQ------------------EEEDIYR--- 850

Human  1179 SVKENGLEPH----LVKKVLEKVSET--FGYRRLEDFMASHLDYLVLEWLNLQDTE---YNLSSF 1234
              .||.:..|    |::..||::..|  |..::..|:.:||....::..|:|...|   :.:|:.
pombe   851 --PENLIRNHQILGLMEGSLEQIRNTDLFILQKYIDYFSSHPHDSLINILHLYPIETFCFGMSAI 913

Human  1235 PFILLNYTNIED--FYRSCYKVLIPHLVIRSHF--DEV----------KSIANQIQEDWKSLLTD 1285
            ....|:.....:  ||: |.::|...:::...:  |||          |.:.:::|      .||
pombe   914 GAYFLDVARTSEPIFYK-CLEILAQKILMNYDYERDEVYLMIFIKIFQKCVHSKLQ------FTD 971

Human  1286 CFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMT 1350
            ...|::|.|..:.                 .||:...|..:|.|:|   .|:    :.:.:|..|
pombe   972 ATLKLIVKITKFI-----------------EKVFIETKFSSLSGRQ---TFL----KFIFQLSPT 1012

Human  1351 LH-------EPANSSASQSTDLC---DFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKS-I 1404
            .|       :...|...:.:|:|   :|..||            ||     ::..|.||.::. :
pombe  1013 SHVYSKFDYQKLISLTLKDSDVCVIYNFVDDL------------VI-----FLKKCDKTLIEGFV 1060

Human  1405 LEILS---------------------------KSPDSYQKILLAICEQAAETNNVY-----KKH- 1436
            |.|||                           :|...||.:.||   .:.||:.::     |.|
pombe  1061 LPILSIKIEKSLYKGFCYLYLTLKVFLSISSNRSALLYQLLKLA---NSYETSTIFEPLLRKLHI 1122

Human  1437 ------RILKIYHL--FVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCI---------- 1483
                  ::.:||.|  |.|.:.||:.:.......|..:.:.::|..::.:....|
pombe  1123 QSANIKQLFRIYRLEIFWSFVSKDLSNTTNDFLEFPYKPIYFSLSDFLKENSDEIILVLILTKNI 1187

Human  1484 -------------------------------------------------MDVSL----RSFSLCC 1495
                                                             :||.|    ::|..|.
pombe  1188 TLAKLITSRMSVDFSEKYTQLIPVITTYTHLSEVENKKYSLRFNSIDEALDVELLNRSKAFLFCL 1252

Human  1496 DLLSQVCQTAVTYCK------------DALENHLHVIVGTLIPL------------VYEQVE--- 1533
            ::|.:|.:...|:..            ....|.:.....|.||.            :::::|
pombe  1253 EMLKEVKELGSTFKSISSTSFKVYSQLTIFANRVSFNNSTAIPFFSTKSVLWYCNRLFQELEGFS 1317

Human  1534 VQKQVLDL-LKYLVID--NKDNENLYITIK--------LLDPF--PDHVVFKDLRITQQKIKYSR 1585
            ....|:|| |:.|.|.  ...:|.|.:||.        ..|||  .:::|...|||.:|.:
pombe  1318 SIPSVIDLVLRRLAIQLHFATDEELQVTISFRLCAFLCFSDPFITSNYLVMIVLRIARQLL---- 1378

Human  1586 GPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVN 1650
                               ::|.|:..||...|..|:..|....|.
pombe  1379 -------------------SIPCTQSLGLGIARFHLKKFKPTDFDY------------------- 1405

Human  1651 LLQLSKMAINHTGEKEVLEAVGSCLGEVGP-----IDFST---------------------IAIQ 1689
            ..||::..         ::.:|.|...:|.     .||.|                     ..|.
pombe  1406 FFQLAEFC---------MDFLGFCYNTIGTKMEAIQDFYTWFDGYVTALLNFEYEGYGFLRCQIN 1461

Human  1690 HSKDASYTK------ALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHS 1748
            ..:....||      :.||||    :..|:....:||.|   |:........|.:|:|     ||
pombe  1462 FVRSVMTTKNEWIEVSNKLFE----RGHFLKRIAMNNYL---CLYFWQVLDACPRNVL-----HS 1514

Human  1749 ----FWEIYKM------------------------------------TTDPMLAYLQPFRTSR-- 1771
                .|:.||.                                    .|||.|...:.:..|:
pombe  1515 LSLEIWKCYKAYDITEFPDSLKLFFSDIMGWNFFKSPEIADLNHYIPKTDPRLCDTKTYEESKLI 1579

Human  1772 ----------------------------------------KKFLEVPR----FD--------KEN 1784
                                                    :|||..|:    :|        :|.
pombe  1580 IWKLICQKACSLLFKYDILLDSFIEDCIRMFFENGNHQELRKFLNFPKDSIIYDSDFKTLVSEEG 1644

Human  1785 PFEGLDDINLWIPLS-ENHDI---WIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYL 1845
            .|:       |:.|. .|.|.   |.|..|...|:..| |......||.:......|..:::.|:
pombe  1645 SFQ-------WVKLQPTNFDSLSNWTKEETLKLLNMMG-KSSTTHSLKLLSTYMVGFSTSIIQYI 1701

Human  1846 IHDILLQ-DTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTM 1909
            ||.|||: |.|.:.:.......|...:..|...:.:.|.|               |::
pombe  1702 IHLILLEFDFNGNNKKQKEYVTQLILSGLLNKNTNSIRKT---------------CMN------- 1744

Human  1910 LAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRS 1974
              ::.|:|||....:...|...:|:.:||...|..|..|..:..:||:..|:..|
pombe  1745 --ILLYLRRQLGHHALNPFEANYWVPINYSVAASTAYDCHLYEQSLLFLTIHNTK---------- 1797

Human  1975 LAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYE-- 2037
                               .:|..|:   ||.:|...:..||:.||         |.|..:::
pombe  1798 -------------------TDELDIT---LLSDILSQLPCPDAYYG---------IKRETSFKNI 1831

Human  2038 -----HEAMWGKALVTYDLETAIPSSTRQAG---IIQALQNLGLCHILSVYLKGLDYENKDWCPE 2094
                 ||.....|:...|......|:..:..   ....|.|.|...:...|:..|  :..|...|
pombe  1832 LLKAVHEKRSPLAISYLDAANMYRSNEDEGTKMMFSNTLNNAGFFSLNEFYIDSL--KANDAIDE 1894

Human  2095 LEELHYQAAWRNMQWD------------HCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESL 2147
            .....|.:|||..:||            .|  :..||....::.::|.....|.:      |.:.
pombe  1895 CSNEVYASAWRMQKWDIPPLSLDNKTTKDC--LVFEVLHAVHNYAIYGNYLHLEE------YINK 1951

Human  2148 KYARVKEVEEMCKRSLESV--YSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHS- 2209
            |...:...||.     :|:  |:|...|..|....:.:...::......::|:|.     |.|.
pombe  1952 KLLLINPNEEP-----DSLLFYALAYDLKFLIRCNQSQFNCDILQLLKENKQMSS-----QLHEC 2006

Human  2210 -QLLKDSDFSFQEPIMALRTVILEILM-EKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPE 2272
             |||           :.:|.|:|.:|. .|::|.|  :.:......:::||..::.:|......:
pombe  2007 FQLL-----------LEIRNVLLSLLQSHKQLDLS--DDLASFRKYYILELLKISESFLIVDNLQ 2058

Human  2273 RAIFQIKQYNSV---SCGVSEWQLE------EAQVFWAKKEQSLALSILKQMIKKLDASCAANNP 2328
            .| |.:...:..   ...:::..|:      .:::.|.:.|:..|:.:|.:.:.|.::|..   |
pombe  2059 NA-FSVAMLSDALYRKFDLADENLKHDIDFLSSKILWQRDEKIDAIGMLSESLSKTNSSIF---P 2119

Human  2329 SLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARF 2393
            |:...|      .||||..|..|...::.:.|.||::....:.:.:.       |.|.:...|:|
pombe  2120 SISYAY------LGNWLYTTKSEKTELVSKNYFEKSLSHMSHLNAKE-------KAKIYCMFAQF 2171

Human  2394 SDTQYQR---IENY--MKSSEFENKQAL--LKRAKEEVGLLREHKIQTNRYTVKVQRELE---LD 2448
            .|..|..   .|::  |:...||.|..:  |:|:......::|.|:..|.::    ||:.   :|
pombe  2172 CDNNYSSPDLTEDFKRMEKLYFEKKNDIQQLERSIVNASNMKEEKMLKNHHS----REMSSFIID 2232

Human  2449 ELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPT 2513
            |.....:...|.:.|.:::.:|:.||...:|:|:.:.|.|::||.||.:.|:|..::.....:|.
pombe  2233 EREYLRMSTFRSKMLTQSITHYLKCLSESDENDVLISRCCTMWLSNSHLDELNNSLQHYLQNLPC 2297

Human  2514 YKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVA 2578
            .||:|:.||||||:   |.....|.:.|.::...:..:||:|:|.::.:|.:
pombe  2298 KKFIPVFYQLAARL---MNENSKFQQSLTSICYNVGRNHPYHSLHVLFSLVS------------- 2346

Human  2579 RRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALC--DAYIILANLDATQWKTQ 2641
                   |||:..:.....|..|..:|:..::..:.......:.||  :.|:.||     :|..:
pombe  2347 -------NVPEIENLDAGSRYRAVKKILDLLKVNQGLSNLVTKLLCSFENYVSLA-----EWNPR 2399

Human  2642 RKGINIPADQ-PITK--LKNLEDVVVP--TMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKI 2701
            .|..:....: |..|  ||:..:..:|  ||.:||:.||:|.|:.|:.||......|.|:|.||:
pombe  2400 SKVDSTSFSRFPGYKWFLKDAANYGLPPITMNVKVNDTGDYSNIPTVSSFDDTIHFASGINAPKV 2464

Human  2702 IDCVGSDGKERRQLVK-GRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSG 2765
            |.|:||:|...:|||| |.|||||||||:|||:..|..|:...:|.:|.|::.||||:||:.::|
pombe  2465 ITCLGSNGHTYKQLVKGGNDDLRQDAVMEQVFEQVNGFLRSYRKTSQRNLSMRTYKVIPLALKTG 2529

Human  2766 VLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPV 2830
            |:||...|:|:||:|    |.|||.|.|.::|...|:|.:.|.|.:..|.:.:|:..||::::||
pombe  2530 VIEWVQDTIPLGEYL----DSAHKVYHPKEWSLSTCRKLIAEKQMEDLETRLKVYDLVCRHYRPV 2590

Human  2831 FRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE 2895
            ||:|.:|.:.||..||..:..|.||.|.:|::|::|||||||.|||||::.|.|::|||||:|||
pombe  2591 FRHFFLESYADPVQWFTTQTNYARSTAVASVLGHVLGLGDRHGQNILIDKTSGEVIHIDLGIAFE 2655

Human  2896 QGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW 2960
            |||.||.||.||||||||:||||||||||||||||.|.|:|.:|..:::||:::|||.|||||.|
pombe  2656 QGKKLPVPECVPFRLTRDVVDGMGITGVEGVFRRCMEFTLETLRREEDSLLSVLEVLRYDPLFSW 2720

Human  2961 TMNPLKALYLQQ-------RPEDETELHPTLNAD-DQECKRNLSDIDQSFNKVAERVLMRLQEKL 3017
            .::||:.:..|:       :||..   :.|.:|. |.:.:||    :.|....|||.::::::||
pombe  2721 LISPLRRMKKQKMQLENFNQPESG---NITTDASRDPKIQRN----NVSGESEAERAILKVRQKL 2778

Human  3018 KGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAW 3055
                 .:.|||...|..||:.|.||..|:.:|.||.|:
pombe  2779 -----SSTLSVEASVGELIRIAQDPSYLALMFCGWSAF 2811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATM	NP_000042.3	TAN	8..165	CDD:463317	32/168 (19%)
		Interaction with ABL1. /evidence=ECO:0000269|PubMed:9168117	1373..1382		0/8 (0%)
		FAT	2097..2489	CDD:396714	86/427 (20%)
		PIKKc_ATM	2683..2962	CDD:270715	148/279 (53%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	2692..2698		2/5 (40%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	2867..2875		6/7 (86%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	2887..2911		19/23 (83%)
		FATC	3026..3055	CDD:460514	13/28 (46%)
		Microbody targeting signal, atypical. /evidence=ECO:0000269|PubMed:26344566	3046..3048		0/1 (0%)
tel1	NP_588126.1	TAN	4..151	CDD:463317	44/219 (20%)
		TEL1	289..2812	CDD:227365	677/3082 (22%)