Protein Alignment NDUFS1 and ND-75

DIOPT Version :10

• Sequence 1: NP_001186913.1
• Gene: NDUFS1 / 4719
• HGNCID: 7707
• Length: 741
• Species: Homo sapiens
• Sequence 2: NP_511083.1
• Gene: ND-75 / 31762
• FlyBaseID: FBgn0017566
• Length: 731
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 453/742 - (61%)
• Similarity: 558/742 - (75%)
• Gaps: 34/742 - (4%)

Human    15 MLRIPVRKALVGLSKSP-----KGCVRTTATAAS------NLIEVFVDGQSVMVEPGTTVLQACE 68
            |:|.|:.||| |...||     ...|||:|..|.      ..||||||...|.|.||||||||..
  Fly     1 MIRAPLVKAL-GALGSPTHQMASRAVRTSAMVAQTPAKAPEKIEVFVDDIPVQVVPGTTVLQAAA 64

Human    69 KVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEF 133
            ::|::||||||||||:|||||||||||:||:||.||||||||||||.|.|||:.::|||||||||
  Fly    65 QIGVEIPRFCYHERLAVAGNCRMCLVEVEKSPKPVAACAMPVMKGWRIKTNSDLTRKAREGVMEF 129

Human   134 LLANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLE----GKRAVEDKNIGPLVKTIMTRCIQCT 194
            ||.||||||||||||||||||||:|.||:|||||.:    ||||||||:|||||||||||||.||
  Fly   130 LLMNHPLDCPICDQGGECDLQDQAMAFGSDRSRFTDINYTGKRAVEDKDIGPLVKTIMTRCIHCT 194

Human   195 RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWET 259
            ||:||||||||||||||||||||||:|||:||:|::|||||:||:|||||||:|||:|.|||||.
  Fly   195 RCVRFASEIAGVDDLGTTGRGNDMQIGTYVEKLFLTELSGNVIDLCPVGALTNKPYSFVARPWEI 259

Human   260 RKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNE 324
            ||..||||:|||||||||||||.||:|||||.:||:||||::||:|||.||||||||..||||..
  Fly   260 RKVSSIDVLDAVGSNIVVSTRTNEVLRILPRENEDVNEEWLADKSRFACDGLKRQRLVAPMVRMP 324

Human   325 KGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTA 389
            .|.|....||.||..||..::: .|..:|.|:|.|.|.||.|||||||||:.|:.:.||:.| .|
  Fly   325 NGELQAVEWEGALIAVAKAIKA-AGGQIAGISGQLADLEAQVALKDLLNRLGSEVVATEQGF-IA 387

Human   390 GAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTY 454
            | |||.|:|||||:||||:||||.|||||||||:||||.|.|:||:::||:|::|.||..:||:|
  Fly   388 G-GTDNRANYLLNSTIAGLEEADAVLLVGTNPRYEAPLVNTRLRKAYVHNELQIASIGPKIDLSY 451

Human   455 TYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSG 519
            .:::||....:::|:.||:|.||:||:.||||.:::|:..|:|.|||||.|.|:...:|::..
  Fly   452 DHENLGADAALVKDVCSGAHAFSKVLEGAKKPAIIIGADLLERADGAAIHATVAEYCKKLKKP-- 514

Human   520 VTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQG 584
               :|...|:|...|:||.|||:|||.|.:...|..|||||||.||.|.:||:.||||||::|.|
  Fly   515 ---NWNPFNVLQTNAAQVGALDVGYKAGAQTAVKAQPKVLFLLNADAGKVTREQLPKDCFVVYIG 576

Human   585 HHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP 649
            .|||.||.|||.:|||||||||...|||||||.|||...|:|||:|||||||:|||||:.|..||
  Fly   577 SHGDNGASIADAVLPGAAYTEKQGIYVNTEGRPQQTLPGVSPPGMAREDWKILRALSEVVGKPLP 641

Human   650 YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSI 714
            ||.||::|||||:|:|:|.|...:|.|.....|..:||.:....:...|    ..::|::|||:|
  Fly   642 YDNLDELRNRLEDVAPHLTRLGQLEPAGDAGAAGTISKSIGGGAIDIKL----KELRDYFMTDAI 702

Human   715 SRASQTMAKCVKAV------TEGAQAV 735
            ||||.|||||:.||      .|..|:|
  Fly   703 SRASPTMAKCISAVNKQQRENEAKQSV 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NDUFS1	NP_001186913.1	NuoG	48..640	CDD:273904	392/595 (66%)
		NADH_dhqG_C	682..724	CDD:462757	16/41 (39%)
ND-75	NP_511083.1	NuoG	44..632	CDD:273904	392/595 (66%)
		NADH_dhqG_C	671..712	CDD:462757	16/44 (36%)