DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-zeta and POL2

DIOPT Version :9

Sequence 1:NP_524881.2 Gene:DNApol-zeta / 47186 FlyBaseID:FBgn0002891 Length:2130 Species:Drosophila melanogaster
Sequence 2:NP_014137.1 Gene:POL2 / 855459 SGDID:S000005206 Length:2222 Species:Saccharomyces cerevisiae


Alignment Length:1276 Identity:208/1276 - (16%)
Similarity:410/1276 - (32%) Gaps:450/1276 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1126 LKAKELLRQREEPKKSSDDIDSPIKIKR---------------------------QKITMMLQ-- 1161
            |.|::||.     ....|||||.:..:|                           ...|::.|  
Yeast    32 LSAQQLLN-----ASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQET 91

  Fly  1162 AEEGDGGSGDEDAGEELDCSLSLTPLS-----------------------QAKDKCKATPTSSKA 1203
            ...|..|.|:.:.||.:..:..::.:.                       ...|:.:........
Yeast    92 LSSGSNGGGNSNDGERVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELV 156

  Fly  1204 RETGKSRLKR----------------G-----TRLSFIGS--------------QDEEPPSSQSS 1233
            ::..:|.||.                |     .:|||:.|              ||....:.|.:
Yeast   157 KKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRN 221

  Fly  1234 EQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCN 1298
            ..:|:::.:: ::|....:..:      |::|:.:.:           :|:::.      ||...
Yeast   222 IYNVAANGSE-KVDAKHLIEDI------REYDVPYHV-----------RVSIDK------DIRVG 262

  Fly  1299 HLTIITLEVFV-STRGDLQPDPMHDEIRCLFYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEGPF 1362
            ....:|.:.|: .||.....||:     .:.:.||.:.|..|.|..|...||:  :..::....|
Yeast   263 KWYKVTQQGFIEDTRKIAFADPV-----VMAFDIETTKPPLKFPDSAVDQIMM--ISYMIDGEGF 320

  Fly  1363 HGIDRDIEVQVVTSEAEAFEAL-----------------LALCERW-------DADIYAGYEIEM 1403
            ...:|:|    ::.:.|.||..                 :||.:|:       ...:.:.:..:.
Yeast   321 LITNREI----ISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDF 381

  Fly  1404 SSWGYVIDRAK--------------------------HL-CFNIAPLLSRVP--TQKVRDFVDED 1439
            ..|.::.:|:|                          |: ||......|.:|  :|.:: .|.:.
Yeast   382 FDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLK-AVTQS 445

  Fly  1440 REQFTDLDVEMKLCGRILLD----VWRLMRSEIALTSYTFENVMYHILHKRC---PWHTAKSLTE 1497
            :..:..::::.:|......:    :.....|:...|.|.:...::..:...|   |.:..::|.:
Yeast   446 KLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRK 510

  Fly  1498 WFGSPCTRWIVMEYYLERVRGTLTLLDQLDLL--GRTSEMAKLIGIQFYEVLSRGSQFRVESMML 1560
            ..|:.|...::::.|...:.......|.::..  |...|....:|            ..|||:..
Yeast   511 GTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVG------------GHVESLEA 563

  Fly  1561 RIAKP--KNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYAD----------------------- 1600
            .:.:.  ||...:.||.........||.|...:|.:::...|                       
Yeast   564 GVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENN 628

  Fly  1601 -----PLIV-LDFQSLYPSM----------IIAYNYCFS--------TCLGRVEHLGGSSPFEFG 1641
                 |||. :|..|:||::          |.|...|.|        ||..:::.......|...
Yeast   629 IRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEFFPSK 693

  Fly  1642 ASQLRVSRQMLQ-------------KLLEHDLVTVSPCGVVFVKREVRE---GILPRM-LTEILD 1689
            ..:..:.::.||             |:|..|.::.:. .|:.:|:.:.|   .:..|: ::||::
Yeast   694 MDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYAD-QVIHIKKRLTEYSRKVYHRVKVSEIVE 757

  Fly  1690 TRQMVKQ------------------------------------SMKLHKDSSALQRILH-SRQLG 1717
            ...:|.|                                    |.|..:|.:....:|: |.||.
Yeast   758 REAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLA 822

  Fly  1718 LKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKV-RVVYGDTDSMFV 1781
            .|::.|..|||.....| |..|:|:.......|...::.|..|||     :| |.:..|||.::.
Yeast   823 HKVILNSFYGYVMRKGS-RWYSMEMAGITCLTGATIIQMARALVE-----RVGRPLELDTDGIWC 881

  Fly  1782 LVPGRNRAEAF-----------------RIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQT---- 1825
            ::| ::..|.:                 .:...:.:..|....|.:|..|..:|:.....|    
Yeast   882 ILP-KSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFE 945

  Fly  1826 --------------------KKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRI 1870
                                ||||..:     :::..:.|.||.|..||.....:......:.::
Yeast   946 VDGPYKAMILPSSKEEGKGIKKRYAVF-----NEDGSLAELKGFELKRRGELQLIKNFQSDIFKV 1005

  Fly  1871 LFETQDVS---KIKAYVCRQFTKLLSGRANL---QDLI--------FAKEFRGLNGYKPTACVPA 1921
            ..|...:.   ...|.||.::..:|.....:   :||:        .:|..:...|.|.|:...|
Yeast  1006 FLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTA 1070

  Fly  1922 LEL---TRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKA 1983
            ..|   ..:.|.||      :|.:..:||.:.|                      .||  .:|:.
Yeast  1071 RRLGDFLGEDMVKD------KGLQCKYIISSKP----------------------FNA--PVTER 1105

  Fly  1984 IIP--------PLNRCLL-----------LIGANVHDW------FASLPRKLLMTPAV--GTANE 2021
            .||        |:.|..|           |....:.||      ..|..:|::..||.  |.:|.
Yeast  1106 AIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNP 1170

  Fly  2022 LAGA---------------RGAKSTISQYFSTTSCVIDCGR 2047
            :...               :..:::::::||.|..|...|:
Yeast  1171 VPRVEHPDWLKRKIATKEDKFKQTSLTKFFSKTKNVPTMGK 1211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-zetaNP_524881.2 PTZ00166 20..>196 CDD:240301
DNA_polB_zeta_exo 1297..1518 CDD:99821 43/281 (15%)
POLBc_zeta 1550..2000 CDD:99917 112/630 (18%)
zf-C4pol 2041..2107 CDD:405022 2/7 (29%)
POL2NP_014137.1 DNA_pol_B_exo1 121..442 CDD:397292 51/356 (14%)
DNA_polB_epsilon_exo 283..486 CDD:99822 33/214 (15%)
POLBc_epsilon 545..1166 CDD:99918 121/675 (18%)
DUF1744 1528..1920 CDD:400678
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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