Protein Alignment PolZ1 and POL2

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_014137.1
• Gene: POL2 / 855459
• SGDID: S000005206
• Length: 2222
• Species: Saccharomyces cerevisiae
• Alignment Length: 1276
• Identity: 208/1276 - (16%)
• Similarity: 410/1276 - (32%)
• Gaps: 450/1276 - (35%)

  Fly  1126 LKAKELLRQREEPKKSSDDIDSPIKIKR---------------------------QKITMMLQ-- 1161
            |.|::||.     ....|||||.:..:|                           ...|::.|
Yeast    32 LSAQQLLN-----ASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQET 91

  Fly  1162 AEEGDGGSGDEDAGEELDCSLSLTPLS-----------------------QAKDKCKATPTSSKA 1203
            ...|..|.|:.:.||.:..:..::.:.                       ...|:.:........
Yeast    92 LSSGSNGGGNSNDGERVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELV 156

  Fly  1204 RETGKSRLKR----------------G-----TRLSFIGS--------------QDEEPPSSQSS 1233
            ::..:|.||.                |     .:|||:.|              ||....:.|.:
Yeast   157 KKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRN 221

  Fly  1234 EQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCN 1298
            ..:|:::.:: ::|....:..:      |::|:.:.:           :|:::.      ||...
Yeast   222 IYNVAANGSE-KVDAKHLIEDI------REYDVPYHV-----------RVSIDK------DIRVG 262

  Fly  1299 HLTIITLEVFV-STRGDLQPDPMHDEIRCLFYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEGPF 1362
            ....:|.:.|: .||.....||:     .:.:.||.:.|..|.|..|...||:  :..::....|
Yeast   263 KWYKVTQQGFIEDTRKIAFADPV-----VMAFDIETTKPPLKFPDSAVDQIMM--ISYMIDGEGF 320

  Fly  1363 HGIDRDIEVQVVTSEAEAFEAL-----------------LALCERW-------DADIYAGYEIEM 1403
            ...:|:|    ::.:.|.||..                 :||.:|:       ...:.:.:..:.
Yeast   321 LITNREI----ISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDF 381

  Fly  1404 SSWGYVIDRAK--------------------------HL-CFNIAPLLSRVP--TQKVRDFVDED 1439
            ..|.::.:|:|                          |: ||......|.:|  :|.:: .|.:.
Yeast   382 FDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLK-AVTQS 445

  Fly  1440 REQFTDLDVEMKLCGRILLD----VWRLMRSEIALTSYTFENVMYHILHKRC---PWHTAKSLTE 1497
            :..:..::::.:|......:    :.....|:...|.|.:...::..:...|   |.:..::|.:
Yeast   446 KLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRK 510

  Fly  1498 WFGSPCTRWIVMEYYLERVRGTLTLLDQLDLL--GRTSEMAKLIGIQFYEVLSRGSQFRVESMML 1560
            ..|:.|...::::.|...:.......|.::..  |...|....:|            ..|||:..
Yeast   511 GTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVG------------GHVESLEA 563

  Fly  1561 RIAKP--KNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYAD----------------------- 1600
            .:.:.  ||...:.||.........||.|...:|.:::...|
Yeast   564 GVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENN 628

  Fly  1601 -----PLIV-LDFQSLYPSM----------IIAYNYCFS--------TCLGRVEHLGGSSPFEFG 1641
                 |||. :|..|:||::          |.|...|.|        ||..:::.......|...
Yeast   629 IRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEFFPSK 693

  Fly  1642 ASQLRVSRQMLQ-------------KLLEHDLVTVSPCGVVFVKREVRE---GILPRM-LTEILD 1689
            ..:..:.::.||             |:|..|.::.:. .|:.:|:.:.|   .:..|: ::||::
Yeast   694 MDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYAD-QVIHIKKRLTEYSRKVYHRVKVSEIVE 757

  Fly  1690 TRQMVKQ------------------------------------SMKLHKDSSALQRILH-SRQLG 1717
            ...:|.|                                    |.|..:|.:....:|: |.||.
Yeast   758 REAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLA 822

  Fly  1718 LKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKV-RVVYGDTDSMFV 1781
            .|::.|..|||.....| |..|:|:.......|...::.|..|||     :| |.:..|||.::.
Yeast   823 HKVILNSFYGYVMRKGS-RWYSMEMAGITCLTGATIIQMARALVE-----RVGRPLELDTDGIWC 881

  Fly  1782 LVPGRNRAEAF-----------------RIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQT---- 1825
            ::| ::..|.:                 .:...:.:..|....|.:|..|..:|:.....|
Yeast   882 ILP-KSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFE 945

  Fly  1826 --------------------KKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRI 1870
                                ||||..:     :::..:.|.||.|..||.....:......:.::
Yeast   946 VDGPYKAMILPSSKEEGKGIKKRYAVF-----NEDGSLAELKGFELKRRGELQLIKNFQSDIFKV 1005

  Fly  1871 LFETQDVS---KIKAYVCRQFTKLLSGRANL---QDLI--------FAKEFRGLNGYKPTACVPA 1921
            ..|...:.   ...|.||.::..:|.....:   :||:        .:|..:...|.|.|:...|
Yeast  1006 FLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTA 1070

  Fly  1922 LEL---TRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKA 1983
            ..|   ..:.|.||      :|.:..:||.:.|                      .||  .:|:.
Yeast  1071 RRLGDFLGEDMVKD------KGLQCKYIISSKP----------------------FNA--PVTER 1105

  Fly  1984 IIP--------PLNRCLL-----------LIGANVHDW------FASLPRKLLMTPAV--GTANE 2021
            .||        |:.|..|           |....:.||      ..|..:|::..||.  |.:|.
Yeast  1106 AIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNP 1170

  Fly  2022 LAGA---------------RGAKSTISQYFSTTSCVIDCGR 2047
            :...               :..:::::::||.|..|...|:
Yeast  1171 VPRVEHPDWLKRKIATKEDKFKQTSLTKFFSKTKNVPTMGK 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	43/281 (15%)
		POLBc_zeta	1550..2000	CDD:99917	112/630 (18%)
		zf-C4pol	2041..2107	CDD:464119	2/7 (29%)
POL2	NP_014137.1	DNA_pol_B_exo1	121..442	CDD:397292	51/356 (14%)
		DNA_polB_epsilon_exo	283..486	CDD:99822	33/214 (15%)
		POLBc_epsilon	545..1166	CDD:99918	121/675 (18%)
		DUF1744	1528..1920	CDD:462493