Protein Alignment PolZ1 and Pola1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_445931.1
• Gene: Pola1 / 85241
• RGDID: 621816
• Length: 1468
• Species: Rattus norvegicus
• Alignment Length: 1564
• Identity: 296/1564 - (18%)
• Similarity: 545/1564 - (34%)
• Gaps: 437/1564 - (27%)

  Fly   767 DEC---SSEIQTTGPRVTTTS-LDRPQKKARLSQSPKENTKTSMNG----------TVALEKATK 817
            |:|   :|.:..:|..|.:.: .::..||.|  |...|..|.:..|          |...|:..:
  Rat     7 DDCKLETSAVSDSGSFVASRARREKKSKKGR--QEALERLKKAKAGEKYKYEVEDLTSVYEEVDE 69

  Fly   818 DSSSNSESPHQQENSV--SEQIEYLES-----KPKKSDETARSCDE--------KLQRELIPQEP 867
            :..|......|.::.:  .:.|.|:|.     .....|:...:|.|        |.::::  ::|
  Rat    70 EQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDTCGEGSDGKAHRKDRKDV--KKP 132

  Fly   868 AGISPGD--------SANSTEEITFSPCHDEAI-----ESDTESDYI------VTKLRKTPNLKR 913
            :...|.:        :...|.:.|.....|:.:     :.:||:..|      :.|.:::.....
  Rat   133 SVTKPNNIKAMFIASAGKKTTDKTVDLSKDDLLGDILQDLNTETPQIAPPPVLIPKKKRSTGASP 197

  Fly   914 LRWSIRSELLNKQFTPSSGIRPPETETTPQLSPK-------SNESNTPELMRSFYEHSLIVNSPS 971
            ..:|:.:...    .||..|..|.:...|.|:|.       :.:...||......|..:|.....
  Rat   198 NPFSVHTATA----VPSGKIASPVSRKEPPLTPVPLKRAEFAGDLAQPECPEDEQESGVIEFEDG 258

  Fly   972 VFSDFLDSPEIHMDSPRSAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPE---YEFQKPYYS 1033
            .|.:.:|:.|:..:.|.:|              ::.....|.|.|.:....||   ..|...:..
  Rat   259 DFDEPMDTEEVDEEEPVTA--------------KIWDQESEPVEGVKHEADPETGTTSFLDSFLP 309

  Fly  1034 NPS--DVSKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQ 1096
            :.|  |:.:..|..||:..:.    .|.:....:.|.|                         ::
  Rat   310 DVSCWDIDQKDENSFLLQEVQ----VDSNHLPLVKGAD-------------------------DE 345

  Fly  1097 KVREYFSTQQRIAIEPAQLAPTWQEA---------------KIWLKAKE-------LLRQREE-- 1137
            :|.:::                |.:|               |:|:::.:       :::..|.
  Rat   346 QVFQFY----------------WLDAYEDPYNQPGVVFLFGKVWVESAKTHVSCCVMVKNIERTL 394

  Fly  1138 ---PKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPT 1199
               |::...|:::. |.....|||             :|..||.|..:|.        |.|....
  Rat   395 YFLPREMKIDLNTG-KETATPITM-------------KDVYEEFDSKISA--------KYKIMKF 437

  Fly  1200 SSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDRSSFLRQLEGSSQDRQH 1264
            .||..|.           ::.....:.|..|:..|...|:...|..       :.|:|.:
  Rat   438 KSKIVEK-----------NYAFEIPDVPEKSEYLEVRYSAEVPQLP-------QNLKGET----- 479

  Fly  1265 DLSFGLSHATLDNTFGFK-------------VNLENLQQAKADID-CNHLTIITLEVFVSTRGDL 1315
                 .||....||...:             :.::|.|.....|. |....:......|:...|:
  Rat   480 -----FSHVFGTNTSSLELFLMNRKIKGPCWLEVKNPQLLNQPISWCKFEAMALKPDLVNVIKDV 539

  Fly  1316 QPDPM----------------HDEIRCLFYAIEHSLPDEKLPSK---ACGYIMVNTVQDLLSEGP 1361
            .|.|:                ..||..:...:.|:.|.:|.|.|   ...:.:|:..:|.:....
  Rat   540 SPPPLVVMSFSMKTMQNVQNHQHEIIAMAALVHHNFPLDKAPPKPPFQTHFCVVSKPKDCIFPCA 604

  Fly  1362 FHGI--DRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLC-FNIAPL 1423
            |..:  .:::||:|..:|.......||...:.|.||..|:.|               | |.:..|
  Rat   605 FKEVIKKKNMEVEVAATERTLLGFFLAKVHKLDPDILVGHNI---------------CGFELEVL 654

  Fly  1424 LSRVPTQKVRDFVDEDREQFTDLDVEMKL------------CGRILLDVWRLMRSEIALTSYTFE 1476
            |.|:...||..:....|.:.:::.   ||            |||::.||...::..|...||...
  Rat   655 LQRINECKVPFWSKIGRLRRSNMP---KLGSRSGFGERNATCGRMICDVEISVKELIHCKSYHLS 716

  Fly  1477 NVMYHILHKRCPWHTAKSLTEWFGSPCTRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGI 1541
            .::..||.........:::...:..|.....::|:..:..|..|.::.:|::|....::..:.|.
  Rat   717 ELVQQILKTERIVIPTENIRNMYSEPSHLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGN 781

  Fly  1542 QFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYL------------------- 1587
            .....|..|...|.|.::|......|.:     |..:...|.|:..
  Rat   782 IMSRTLMGGRSERNEFLLLHAFYENNYI-----VPDKQIFRKPQQKPGDEDEEIDGDTNKYKKGR 841

  Fly  1588 -------ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQL 1645
                   .|:::|:..||...:::|||.|||||:|..:|.||:|.                   .
  Rat   842 KKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTV-------------------Q 887

  Fly  1646 RVSRQMLQKLLEHDLVTVSPCGVVFVKREVRE--------GILPRMLTEILDTRQMVKQSMKLHK 1702
            ||:.:.|:...:.:            :.::.|        |||||.:.::::.|:.|||.||...
  Rat   888 RVASETLKATEDEE------------QEQIPELPDPNLDMGILPREIRKLVERRKQVKQLMKQQD 940

  Fly  1703 DSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEW 1767
            .:..|......||..|||.||..||....::| |..:..:...|..||||.|....::|   ::.
  Rat   941 LNPDLVLQYDIRQKALKLTANSMYGCLGFSYS-RFYAKPLAALVTYKGREILMHTKEMV---QKM 1001

  Fly  1768 KVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGY 1832
            .:.|:||||||:.:.....|..|.|::|.::...|.::. :.:::.::.|::..:|..||:|...
  Rat  1002 NLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKNEVNKLY-KLLEIDIDGVFKSLLLLKKKKYAAL 1065

  Fly  1833 MYETADQEQPV--YEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKA-YVCRQFTKLLSG 1894
            :.|.......:  .|.||::.||||.|                  |::|... :|..|   :||.
  Rat  1066 VVEPTSDGNYITKQELKGLDIVRRDWC------------------DLAKDTGNFVIGQ---ILSD 1109

  Fly  1895 RA------NLQDLIFAKEFRGLNGYKPTACVPALELTRKWMQKDPRHVP---------------- 1937
            ::      |:|..:.......|||..|   |...|: .|.:.|||:..|
  Rat  1110 QSRDTIVENIQKRLIEIGENVLNGSVP---VSQFEI-NKALTKDPQDYPDKKSLPHVHVALWINS 1170

  Fly  1938 ------RRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNR-C---- 1991
                  :.|:.|.::|......:...:...:|..:...:...|:..||:.:.|.|.:.| |
  Rat  1171 QGGRKVKAGDTVSYVICQDGSNLPATQRAYAPEQLQKQDNLAIDTQYYLAQQIHPVVARICEPID 1235

  Fly  1992 -------LLLIGAN-----VHDWFASLPR-KLLMTPAVGTANE----------LAGARGAKSTIS 2033
                   .|.:|.:     ||.:...... .||..||..|..|          |..:.|.::...
  Rat  1236 GIDAVLIALWLGLDSTQFRVHQYHKDEENDALLGGPAQLTDEEKYKDCEKFKCLCPSCGTENIYD 1300

  Fly  2034 QYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDK----TARLERGYQLTRQICQ--ACCGR 2092
            ..|..:...::......:.|  ||..:..|.:|.||:|    ..|..:.|.....||:  .|..|
  Rat  1301 NVFEGSGMDMEPSLNRCSNI--DCKASPATFMVQLSNKLIMDIRRCIKKYYDGWLICEEPTCRNR 1363

  Fly  2093 LGSL 2096
            :..|
  Rat  1364 IRRL 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	48/254 (19%)
		POLBc_zeta	1550..2000	CDD:99917	117/531 (22%)
		zf-C4pol	2041..2107	CDD:464119	15/62 (24%)
Pola1	NP_445931.1	pol2	56..1232	CDD:273159	255/1374 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..135		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..226		11/55 (20%)
		DNA-binding. /evidence=ECO:0000255	657..722		14/67 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..836		2/19 (11%)
		DNA-binding. /evidence=ECO:0000255	1252..1383		26/118 (22%)
		zf-DNA_Pol	1272..1461	CDD:462651	21/98 (21%)
		CysB motif	1355..1381		4/13 (31%)