Protein Alignment PolZ1 and TIL1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_172303.5
• Gene: TIL1 / 837346
• AraportID: AT1G08260
• Length: 2161
• Species: Arabidopsis thaliana
• Alignment Length: 2425
• Identity: 424/2425 - (17%)
• Similarity: 749/2425 - (30%)
• Gaps: 959/2425 - (39%)

  Fly    70 YLYIPYDKK--DFESLERGILQMAMHLD----KAINISLGQGSSNAQHVFKIQLVKGIPFYGYHR 128
            ||...|:::  |.|.:|:..|.:..||.    |.:.||.       ..|.::..||....:...|
plant   105 YLRRRYERQVADIEIVEKEDLDLKNHLSGLQKKYLKISF-------DTVQQLMEVKRDLLHIVER 162

  Fly   129 VEHQF--LKIY--MFNPRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVP 189
            .:.:|  |:.|  :...:..:|..:.|.|...|      .|..|||.::|.||.::....:.:|.
plant   163 NQAKFDALEAYESILAGKREQRPQDCLDSIVDL------REYDVPYHVRFAIDNDVRSGQWYNVS 221

  Fly   190 L---EVLKFRRNHDDDVIPYANVKQAQLLDITTAK-----------KVACSALEVDVSSNFILNR 240
            :   :|:..:|.   |::..|.|:.. ..||.|.|           ::...:..||.....|:||
plant   222 ISSTDVILEKRT---DLLQRAEVRVC-AFDIETTKLPLKFPDAEYDQIMMISYMVDGQGFLIINR 282

  Fly   241 --------------------FQLVAKSKS------------NHTNPGIEAIWND--------EKL 265
                                :..|...|:            ....|||...:|.        |:.
plant   283 ECVGEDVEDLEYTPKPEFEGYFKVTNVKNEVELLQRWFYHMQELKPGIYVTYNGDFFDWPFIERR 347

  Fly   266 RRQKLVEKHTDAG---DEEKAEAVPVLE--------------LPPTQERH-------------QI 300
            .....::.:.:.|   |:.:.|......              ||  |..|             .:
plant   348 ASHHGIKMNEELGFRCDQNQGECRAKFACHLDCFAWVKRDSYLP--QGSHGLKAVTKAKLGYDPL 410

  Fly   301 EIAESDIFYRTALESKLMTLEQSTLSE--------QTLSDQTILPQATMQTTMPGTKAQKRRFNL 357
            |:...|: .|.|:| |..|:...::|:        .|..:..|...||:...:|....:|....|
plant   411 EVNPEDM-VRFAME-KPQTMASYSVSDAVATYYLYMTYVNPFIFSLATIIPMVPDEVLRKGSGTL 473

  Fly   358 QKLL-------ANAVYPEECSQD-----QQQLLVNASFIQNHVTC----GYSSSVSLSTSKDES- 405
            .::|       ||.|.|.:...|     |.|||.:.::|..||.|    .:.|.:..|...|.|
plant   474 CEMLLMVEAYKANVVCPNKNQADPEKFYQNQLLESETYIGGHVECLESGVFRSDIPTSFKLDSSA 538

  Fly   406 -----DDLDETVVDEELILSLTQPHGAIPHDATLREEDL--ELLDALQLLEEQNESESHVDLDSS 463
                 |:|..   |.|..:::   .|.:..|:....:::  |:.:.|:.|.:....|.
plant   539 YQQLIDNLGR---DLEYAITV---EGKMRMDSISNYDEVKDEIKEKLEKLRDDPIREE------- 590

  Fly   464 LAPLSQHKKF-ELTPELLDKETAATAALFDEDVDSDEDADQETRHDFS----TVLDDVDEL---- 519
             .||..|... .:.|.::     .|..|....:.:||..   |..||:    |.|..::.:
plant   591 -GPLIYHLDVAAMYPNII-----LTNRLQPPSIVTDEIC---TACDFNRPGKTCLRKLEWVWRGV 646

  Fly   520 -----------LLKLTQSQPAESKELKASSK----LPQIDGADDRLQRTPIKSISSKSKSSPSKT 569
                       |.|..:|:..::.....|||    ||::|......:|  :|....|:.......
plant   647 TFMGKKSDYYHLKKQIESEFVDAGANIMSSKSFLDLPKVDQQSKLKER--LKKYCQKAYKRVLDK 709

  Fly   570 PTTPIGQKSL-----PKSPRTPKTSAAKKYAPLALTIGSSSSKKSNDEFAGRPSNPRL---SLQL 626
            |.|.:.:..:     |....|.::...::|          ..|..|..:.|:.|..:.   |:::
plant   710 PITEVREAGICMRENPFYVDTVRSFRDRRY----------EYKTLNKVWKGKLSEAKASGNSIKI 764

  Fly   627 DQGTGTGTLRPEISLRKKLAMSE-----MRR------------------KSFEDSFVLLKNDCTP 668
            .:......:...:.|..|..::.     ||:                  |..:::.:|::....|
plant   765 QEAQDMVVVYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKP 829

  Fly   669 VRSTRRSTSNLDKTHIICSLTPRDRNPGL---SDMFETEDGKQLPPKKVVRKTRWSTRNQDIESL 730
            :        .||...|.|.|      ||.   :..|:|.|.|:|                 ..|.
plant   830 L--------ELDTDGIWCCL------PGSFPENFTFKTIDMKKL-----------------TISY 863

  Fly   731 PKAGCEIERPHRSEGSALDE----LKPRRSARHKVNSANPDECSSEIQTTGPRVTTTSLDRPQKK 791
            |   |.:.....::.:..|:    :.|.|.. :|.:|    |||.|.:..||           .|
plant   864 P---CVMLNVDVAKNNTNDQYQTLVDPVRKT-YKSHS----ECSIEFEVDGP-----------YK 909

  Fly   792 ARLSQSPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLESKPKKSDETARSCDE 856
            |.:..:.||.       .:.::|        ..:....:.:::|         .|..|..|..:.
plant   910 AMIIPASKEE-------GILIKK--------RYAVFNHDGTLAE---------LKGFEIKRRGEL 950

  Fly   857 KL----QRELIPQEPAGISPGD--SA-------------NSTEEITFSPCHDEAIESDTES---- 898
            ||    |.||..:...|.:..:  ||             |..::|..|...|...||.|.|
plant   951 KLIKVFQAELFDKFLHGSTLEECYSAVAAVADRWLDLLDNQGKDIADSELLDYISESSTMSKSLA 1015

  Fly   899 DYIVTKLRKTPNLKRLRWSIRSELLNKQFTPSSGIR--------PPETETTPQLSPKSNESNTPE 955
            ||...|.......|||     :|.|........|:|        |..|..:.:..|.:..:..||
plant  1016 DYGEQKSCAVTTAKRL-----AEFLGVTMVKDKGLRCQYIVACEPKGTPVSERAVPVAIFTTNPE 1075

  Fly   956 LMR---------------------SFYEHSL------IVNSPSVFSDFLDSPEIHMDSPRSAPPS 993
            :|:                     |:|:..|      ::..|:...      ::....||...|.
plant  1076 VMKFHLRKWCKTSSDVGIRLIIDWSYYKQRLSSAIQKVITIPAAMQ------KVANPVPRVLHPD 1134

  Fly   994 ----------------------PDSNSFVIAPLELPPSYDEVVSGSRKMDIPEY-EFQKPYYSNP 1035
                                  ..:|..|:...:||.:.|.|      .||.:: :..:|....|
plant  1135 WLHKKVREKDDKFRQRKLVDMFSSANKDVVLDTDLPVTKDNV------EDIEDFCKENRPSVKGP 1193

  Fly  1036 SDVSKVTEVGFLVLHIPGNKLNDCD------------PFQSILGNDRGL----------ASW--- 1075
            ..:::..||        ..|.::|:            .||:|   |:.:          ..|
plant  1194 KPIARSYEV--------NKKQSECEQQESWDTEFHDISFQNI---DKSVNYQGWLELKKRKWKVT 1247

  Fly  1076 ----RRRQLIAIGGLAMLQRHRGEQKVRE-------YFSTQQRIAI----EPAQLAPTWQEAKI- 1124
                ::|:|..:.....:..|...|||.:       ||...:....    :..||.|:.|..:.
plant  1248 LEKKKKRRLGDLRSSNQVDTHEINQKVGQGRGGVGSYFRRPEEALTSSHWQIIQLVPSPQSGQFF 1312

  Fly  1125 -WLKAKELLRQ--REEPK----KSSDDID---------------------SPIKI------KRQK 1155
             |:..:.|:.:  ...|:    .|...||                     :.:||      |..|
plant  1313 AWVVVEGLMLKIPLSIPRVFYINSKVPIDEYFQGKCVNKILPHGRPCYSLTEVKIQEDQFKKESK 1377

  Fly  1156 ITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKAR--------ETGKSRLK 1212
            ....|.|:.|..|.      .|....|..:.:.|....||   ..:||:        |.|:..:|
plant  1378 KRAALLADPGVEGI------YETKVPLEFSAICQIGCVCK---IDNKAKHRNTQDGWEVGELHMK 1433

  Fly  1213 RGTRLSFIGSQDEEPPSSQSSEQSV-------SSSAAQA-----------------------ELD 1247
            ..|...::             ::|:       |:|..:|                       ||.
plant  1434 TTTECHYL-------------KRSIPLVYLYNSTSTGRAIYVLYCHVSKLMSAVVVDPFNGNELL 1485

  Fly  1248 RSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNL--------------------ENLQQAK 1292
            .|:..||...|.      |...|...:.|. ..|:|:.                    ||.....
plant  1486 PSALERQFRDSC------LELSLDSLSWDG-IRFQVHYVDHPEAAKKIIQRAISEYREENCGPTV 1543

  Fly  1293 ADIDCNHLTII------------------------------------------------------ 1303
            |.|:|...|.:
plant  1544 AVIECPDFTFMKEGIKALDDFPCVRIPFNDDDNSYQPVSWQRPAAKIAMFRCAAAFQWLDRRITQ 1608

  Fly  1304 ------------------TLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLPD------------- 1337
                              |:::|:|.       .:.|:.:.|:.: ::.:||
plant  1609 SRYAHVPLGNFGLDWLTFTIDIFLSR-------ALRDQQQVLWVS-DNGVPDLGGINNEEAFFAD 1665

  Fly  1338 -------------------EKLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQVVTSE------ 1377
                               .|:.:.|...::.:.:.:.:..|.|.|.::|:..:.:.|.
plant  1666 EVQQTSLVFPGAYRKVSVELKIHNLAVNALLKSNLVNEMEGGGFMGFEQDVNPRGINSNDNTSFD 1730

  Fly  1378 -----AEAFEALLALCE------RWDADIYAGYEIEMSSW------GYVIDRAKHLCFNIAPLLS 1425
                 |:||..|..|..      |...:|||...::..||      ..:.|.|.||      :|.
plant  1731 ETTGCAQAFRVLKQLIHSCLTDVRKSKNIYADSILQRLSWWLCSPSSKLHDPALHL------MLH 1789

  Fly  1426 RVPTQKVRDFVDEDREQFTDLDVEMKLCGRILL--DVWRLMRSEIALTSYTFENVMYHILHKRCP 1488
            :| .|||          |..|..:::..|.|::  |.     |::.:.:..|:
plant  1790 KV-MQKV----------FALLLTDLRRLGAIIIYADF-----SKVIIDTVKFD------------ 1826

  Fly  1489 WHTAKSLTEWF-----GSPCTRWIVME--YYLERVRGTLTLLDQLDLLG-RTSEMAKLIGIQFYE 1545
            ...||:..|..     .|....||::|  :|..    :|..:||.:..| |..:...|
plant  1827 LSAAKAYCESLLSTVRNSDIFEWILLEPVHYWH----SLLFMDQYNYAGIRADDEISL------- 1880

  Fly  1546 VLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSL 1610
                                 :.|.:.|......|:  |||                |..||
plant  1881 ---------------------DEVTIEPKWSVARHL--PEY----------------IERDF--- 1903

  Fly  1611 YPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREV 1675
               :||...:.|......:|:..|||.        .:..||::.|.|.       .|..|:
plant  1904 ---IIIIAKFIFDPWKFAIENKKGSSE--------SLEAQMIEYLREQ-------IGSTFI---- 1946

  Fly  1676 REGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSV 1740
              .:|.:.:.:|:.                      |.:::      ||:   .|:..||:.|
plant  1947 --NMLVKKVDDIMS----------------------HMKEI------NVS---DASRVSGQAP-- 1976

  Fly  1741 EVGDSVVSKGRETLE-----RAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAK 1800
                    ||..:||     .|:..::.|       |..|     |||..::..:..:: :|.|.
plant  1977 --------KGDYSLEFIQVISAVLALDQN-------VQQD-----VLVMRKSLLKYIKV-KECAA 2020

  Fly  1801 AVTEMNPQPVKL-------------KLEKVYQPCMLQTKKRY------VGYMYETADQEQPVYEA 1846
            ....::|.|..:             .|:....|.:| |:|.:      .|.:|   |:||  .|:
plant  2021 EAEFLDPGPSFILPNVACSNCDAYRDLDICRDPALL-TEKEWSCADTQCGKIY---DREQ--MES 2079

  Fly  1847 KGIETVRRDGCPAVAKMLEKVLRILFETQDV-----SKIKA------------YVCRQFTKLLSG 1894
            ..:|.||:         .|:    ::..|||     :::||            :.|::.....|.
plant  2080 SLLEMVRQ---------RER----MYHMQDVVCIRCNQVKAAHLTEQCECSGSFRCKESGSEFSK 2131

  Fly  1895 RANL-QDLIFAKEFRGLNGY 1913
            |..: .|:...::||.|..|
plant  2132 RMEIFMDIAKRQKFRLLEEY 2151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301	32/138 (23%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	51/356 (14%)
		POLBc_zeta	1550..2000	CDD:99917	74/406 (18%)
		zf-C4pol	2041..2107	CDD:464119
TIL1	NP_172303.5	DNA_pol_B_exo1	72..400	CDD:397292	59/313 (19%)
		DNA_polB_epsilon_exo	240..444	CDD:99822	32/208 (15%)
		POLBc_epsilon	505..1122	CDD:99918	133/735 (18%)
		DUF1744	1489..1872	CDD:462493	66/435 (15%)