DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and AT5G63960

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001190611.1	Gene:	AT5G63960 / 836517	AraportID:	AT5G63960	Length:	1112	Species:	Arabidopsis thaliana

Alignment Length:	1290	Identity:	328/1290 - (25%)
Similarity:	508/1290 - (39%)	Gaps:	279/1290 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   931 SGI---RPPETETTPQLSP-KSNESNTP---------ELMRS---FYEHSLIVNSPSVFSDFLDS 979
            |||   |||.:.|.|.... ::...:||         |.|..   |.:.:|:.......|..|..
plant     4 SGISKKRPPPSNTPPPAGKHRATGDSTPSPAIGTLDDEFMMEEDVFLDETLLYGDEDEESLILRD 68

  Fly   980 PEIHMDSPRSA---PP-SP----DSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPS 1036
            .| ..:|..||   || ||    :|.|.:...||:    |.:::.|.|..:|....|.|...
plant    69 IE-ERESRSSAWARPPLSPAYLSNSQSIIFQQLEI----DSIIAESHKELLPGSSGQAPIIR--- 125

  Fly  1037 DVSKVTEVG-------------FLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAM 1088
             :..||..|             |.:...||...:|...|...|
plant   126 -MFGVTREGNSVCCFVHGFEPYFYIACPPGMGPDDISNFHQSL---------------------- 167

  Fly  1089 LQRHRGEQKVREYFSTQQRIAIEPAQLAPTWQEAKI--WLKAKELLRQREEPKKSSDDIDSPIKI 1151
                  |.::||                 :.:.||:  ::|..|::::|...........:.:||
plant   168 ------EGRMRE-----------------SNKNAKVPKFVKRIEMVQKRSIMYYQQQKSQTFLKI 209

  Fly  1152 KRQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKARETGKSRLKRGTR 1216
            .....||:....      |..|.|.::| .|.:                 |:.:|.:|.:....|
plant   210 TVALPTMVASCR------GILDRGLQID-GLGM-----------------KSFQTYESNILFVLR 250

  Fly  1217 L----SFIGSQDEEPPSSQSSEQSVSSSAAQAEL-----DRSSFLRQLEGSSQDRQHDLSFGLSH 1272
            .    ..:|....|.|:.:..:.:.:.|..|.|.     |..|...:.|.|.......|||
plant   251 FMVDCDIVGGNWIEVPTGKYKKNARTLSYCQLEFHCLYSDLISHAAEGEYSKMAPFRVLSF---- 311

  Fly  1273 ATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLPD 1337
                                 ||:|           ...:|.. |:..||.:..:...:  :|..
plant   312 ---------------------DIEC-----------AGRKGHF-PEAKHDPVIQIANLV--TLQG 341

  Fly  1338 EKLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQVVTSEAEAFEALLA---------------- 1386
            |..|       .|..|..|.|..|..|:|      |::.|.|. |.|||
plant   342 EDHP-------FVRNVMTLKSCAPIVGVD------VMSFETER-EVLLAWRVLFLPLHYYICITS 392

  Fly  1387 ----LCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQ--KVRDFVDEDREQFTD 1445
                |....|.||..||.|......|:|:||..|.....|||.||...  :|||.....|:|...
plant   393 SSSDLIRDVDPDIIIGYNICKFDLPYLIERAATLGIEEFPLLGRVKNSRVRVRDSTFSSRQQGIR 457

  Fly  1446 LDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHIL--HKRCPWHTAKSLTE-WFGSPCTRWI 1507
            ...|..:.||...|:.:.:..:..|:||:..:|..|.|  .|....|:.  :|: ..|:..||..
plant   458 ESKETTIEGRFQFDLIQAIHRDHKLSSYSLNSVSAHFLSEQKEDVHHSI--ITDLQNGNAETRRR 520

  Fly  1508 VMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLS 1572
            :..|.|:.......|||:|..:....|||::.|:....:|:||...:|.|.:||..|.||||  .
plant   521 LAVYCLKDAYLPQRLLDKLMFIYNYVEMARVTGVPISFLLARGQSIKVLSQLLRKGKQKNLV--L 583

  Fly  1573 PSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSP 1637
            |:.:.....:.....|.::|.::.||..|:..|||.|||||:::|||.|:.|.
plant   584 PNAKQSGSEQGTYEGATVLEARTGFYEKPIATLDFASLYPSIMMAYNLCYCTL------------ 636

  Fly  1638 FEFGASQLRVSRQMLQKL-LEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLH 1701
                     |:.:.::|| |..:.||.:|.|..|||:.:::||||.:|.|:|..|:..|..:|..
plant   637 ---------VTPEDVRKLNLPPEHVTKTPSGETFVKQTLQKGILPEILEELLTARKRAKADLKEA 692

  Fly  1702 KDSSALQR-ILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVEN-- 1763
            ||  .|:: :|..|||.||:.||..||:|.|.. |::|.:|:..||.|.||:.:|:..||||:
plant   693 KD--PLEKAVLDGRQLALKISANSVYGFTGATV-GQLPCLEISSSVTSYGRQMIEQTKKLVEDKF 754

  Fly  1764 ----NEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQ 1824
                ..::...|:||||||:.|.....:...|..:|.|.|:.::....:|:||:.||||.|.:|.
plant   755 TTLGGYQYNAEVIYGDTDSVMVQFGVSDVEAAMTLGREAAEHISGTFIKPIKLEFEKVYFPYLLI 819

  Fly  1825 TKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFT 1889
            .||||.|.:: |..|:....:.|||||||||.|..|..::.:.|..:...:||......|.:..:
plant   820 NKKRYAGLLW-TNPQQFDKMDTKGIETVRRDNCLLVKNLVTESLNKILIDRDVPGAAENVKKTIS 883

  Fly  1890 KLLSGRANLQDLIFAK---------EFRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPF 1945
            .||..|.:|..|:..|         |.:..:|          ||..:..::|....|..|:|||:
plant   884 DLLMNRIDLSLLVITKGLTKTGDDYEVKSAHG----------ELAERMRKRDAATAPNVGDRVPY 938

  Fly  1946 IIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNRCL--LLIGANVHDWFASLPR 2008
            :|:....|.:.......|..:|.| ...|:..||:...|..||.|..  :|..|:......|..|
plant   939 VIIKAAKGAKAYERSEDPIYVLQN-NIPIDPNYYLENQISKPLLRIFEPVLKNASKELLHGSHTR 1002

  Fly  2009 KLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDKTA 2073
            .:.:|....:        |......:..|...|.:.....|   :|..|.............:.|
plant  1003 SISITTPSNS--------GIMKFAKKQLSCVGCKVPISNGT---LCASCKGREAELYCKNVSQVA 1056

  Fly  2074 RLERGYQLTRQICQACCGRL-GSLQCDSLDCPVLYVLEGKRREL----QQIEHWN 2123
            .||..:......||.|.|.| ..:.|.|.|||:.|.....::::    ||::.|:
plant  1057 ELEEVFGRLWTQCQECQGSLHQDVLCTSRDCPIFYRRMKAQKDMAVARQQLDRWS 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	62/245 (25%)
		POLBc_zeta	1550..2000	CDD:99917	151/468 (32%)
		zf-C4pol	2041..2107	CDD:405022	17/66 (26%)
AT5G63960	NP_001190611.1	PTZ00166	81..1109	CDD:240301	307/1208 (25%)
		DNA_polB_delta_exo	300..546	CDD:99820	72/300 (24%)
		POLBc_delta	595..988	CDD:99916	138/428 (32%)
		zf-C4pol	1024..1093	CDD:290959	18/71 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820