DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-zeta and pold1

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001039204.1	Gene:	pold1 / 734063	XenbaseID:	XB-GENE-1002131	Length:	1109	Species:	Xenopus tropicalis

Alignment Length:	962	Identity:	256/962 - (26%)
Similarity:	412/962 - (42%)	Gaps:	176/962 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1207 GKSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLS 1271
            ||.||::       .||||.|    |.|.....|.||.|:|.|             ..||   :|
Frog   265 GKYRLRK-------ESQDEGP----SKENPSKVSLAQIEVDIS-------------WADL---IS 302

  Fly  1272 HATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLP 1336
            |.    ..|....:..|:....||:|            :.|..:.|:|..|.:
Frog   303 HP----AEGDWQKIAPLRVLSFDIEC------------AGRKGVFPEPDKDPV------------ 339

  Fly  1337 DEKLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEV-----QVVTSEAEAFEALLALCERW----- 1391
                         :.....:|.:|......|::..     .:|.|:...|:...||.:.|
Frog   340 -------------IQIANMVLRQGEKDAFIRNVFTLGTCSSIVGSQVLCFDREDALLKAWADFVR 391

  Fly  1392 --DADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQK--VRDFVDEDREQFTDLDVEMKL 1452
              |.||..||.|:.....|:|:||:.|.....|.|.|:.:.|  :||...:.::.....:..:..
Frog   392 TIDPDIITGYNIQNFDMPYLINRAQTLKVPNFPFLGRIRSMKSVIRDSSFQSKQMGRRENKVINT 456

  Fly  1453 CGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHTAKSLTE-WFGSPCTRWIVMEYYLERV 1516
            .||:..|:.:::..:..|.|||...|.:|.|.::........:|: ..|:..||..:..|.|:..
Frog   457 EGRVQFDLLQVLLRDYKLRSYTLNAVSFHFLQEQKEDVQHSIITDLQNGNEQTRRRLAVYCLKDA 521

  Fly  1517 RGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHM 1581
            ...|.|:::|..:....|||::.|:....:||||.|.:|.|.:||.|..::||  .|.|::..
Frog   522 YLPLRLMEKLMCVINYMEMARVTGVPLSYLLSRGQQIKVVSQLLRQAMKQDLV--MPVVKSEG-- 582

  Fly  1582 RAPEYL-ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCL--GRVEHLGGSSPFEFGAS 1643
             ..:|. |.::||...:|..|:..|||.|||||:::|:|.|::|.|  |.::.. |.||.:|
Frog   583 -GEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLQSGSIDKY-GLSPEDF--- 642

  Fly  1644 QLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQ 1708
                              ..:|.|..|||..:|:|:||.:|..:|..|:..|..:|...|... |
Frog   643 ------------------IKTPTGDCFVKASIRKGLLPEILENLLCARKRAKAELKKETDPFK-Q 688

  Fly  1709 RILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVE------NNEEW 1767
            ::|..|||.||:.||..||:|.|.. |::|.:|:..||...||:.:|:..:|||      |..:.
Frog   689 KVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTLDNGYKA 752

  Fly  1768 KVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGY 1832
            ..:|:||||||:...:..:...||..||.|.|:.|:.....|:||:.||||.|.:|..||||.|.
Frog   753 DAKVIYGDTDSVMCKLGVQTVVEAMEIGREAAEWVSSHFTPPIKLEFEKVYFPYLLINKKRYAGL 817

  Fly  1833 MYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRAN 1897
            .:.::.......:.|||||||||.||.||.::...|:.:...:|......:.....:.||..|.:
Frog   818 YFSSSANTHDKMDCKGIETVRRDNCPLVANLINTCLQKILIDRDPMGAVEHAKDVISDLLCNRID 882

  Fly  1898 LQDLIFAK-------EFRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQ 1955
            :..|:..|       |:.|...:        :||..:..::||...|..|:|||::|:....|:.
Frog   883 ISQLVITKELTRTADEYAGKQAH--------VELAERMRKRDPGSAPNLGDRVPYVIIGAAKGVA 939

  Fly  1956 LIRLVRSPHDILANEGHKINAIYYITKAIIPPLNR------------CLLLIGANVHDWFASLPR 2008
            .......|..:|.| ...|:..||:.:.:..||.|            .:||.|.:..       .
Frog   940 AYMKSEDPIYVLEN-NIPIDTQYYLEQQLAKPLLRIFEPILGESKAESILLKGEHTR-------C 996

  Fly  2009 KLLMTPAVGTANELAGAR----GAKSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLS 2069
            |.::|..||.....|..|    |.|:|::.               ...:|..|.:..:..:....
Frog   997 KTVLTAKVGGLMAFAKKRSTCIGCKATLNH---------------DGAVCNYCKQRESELIQKEI 1046

  Fly  2070 DKTARLERGYQLTRQICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIE 2120
            .:.:.||..:......||.|.|.| ..:.|.|.|||:.|:.:..:::|...|
Frog  1047 SQLSGLEEKFSRLWTQCQRCQGSLHEDVLCTSRDCPIFYMRKKVQKDLDDQE 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	47/235 (20%)
		POLBc_zeta	1550..2000	CDD:99917	148/477 (31%)
		zf-C4pol	2041..2107	CDD:405022	14/66 (21%)
pold1	NP_001039204.1	PTZ00166	76..1105	CDD:240301	256/962 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010