DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and REV3L

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	XP_011534330.1	Gene:	REV3L / 5980	HGNCID:	9968	Length:	3157	Species:	Homo sapiens

Alignment Length:	3241	Identity:	887/3241 - (27%)
Similarity:	1297/3241 - (40%)	Gaps:	1210/3241 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VYSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPY 75
            ::|||:|.||:||..|..|:|.|.|.|....:|:|||:||||....|||||:|:||:|||||:||
Human     1 MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPY 65

  Fly    76 DKKDFESLERGILQMAMHLDKAINISLGQGSSNAQHVFKIQLVKGIPFYGYHRVEHQFLKIYMFN 140
            |... :..|..:.|||..:|:|:|::||..||.||||||:.||.|:||||||..|..|:|||::|
Human    66 DGYG-QQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYN 129

  Fly   141 PRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFR--------- 196
            |..|:|...|||||||::|.:.|||:|:||:||..||||||||:.::  |..:|||
Human   130 PTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLIN--LAAVKFRKARRKSNTL 192

  Fly   197 ------RNH-------------DDDVIPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQ 242
                  :||             :.|.||.:.:.:.      ...:..|. ||||..:..||||..
Human   193 HATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEG------VEPQSTCE-LEVDAVAADILNRLD 250

  Fly   243 LVAKSKSNHTNPGIEAIWNDEKLRRQKLVE-KHTDAGDEEKAEAVPVLELPPT-QERHQIEIAES 305
            :.|:...   |||::|||.|||.||:...| ......:.:....||..|.... |:|.|..:.::
Human   251 IEAQIGG---NPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQN 312

  Fly   306 DIFYRT------------------ALESKLMT----------------------------LEQST 324
            |...||                  .|.|::::                            :|::.
Human   313 DFSVRTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKDKESSKGHTRHKVEEAL 377

  Fly   325 LSEQTL-----SDQTILPQATMQTTMP---------------------GTKAQKRRF-NLQKLLA 362
            ::|:.:     :.||..|.....:..|                     |.:.::.|. :..:...
Human   378 INEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAGLESDGYRGERNRMPSPCRSFG 442

  Fly   363 NAVYPEECSQDQQQLLVNA--------------SFIQNHVTCGYSSSVSLSTSKDESDDLDETVV 413
            |..||:....::.:..:..              |.|:.|  |....|:..:|.:..::| |::..
Human   443 NNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEH--CAKKRSLCRNTHRSSTED-DDSSS 504

  Fly   414 DEE--------LILSLTQP---------------------HGAI--------------------- 428
            .||        |:.||:.|                     |.::
Human   505 GEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNENSRTHSSVIATSKLSVKPSIFHKDAATLE 569

  Fly   429 -----------PHDATLREEDLELLDALQLLEEQNE-SESHVD-------------------LDS 462
                       .|.:.|....|...|.::.|.:.|: :|..:|                   |.|
Human   570 PSSSAKITFQCKHTSALSSHVLNKEDLIEDLSQTNKNTEKGLDNSVTSFTNESTYSMKYPGSLSS 634

  Fly   463 SLAPLSQHK---KFELTPELLDKETAATAALFD--EDVDS----------------DEDA----- 501
            ::...:.||   |.|:.|     .::..:::||  ||:.|                ::|:
Human   635 TVHSENSHKENSKKEILP-----VSSCESSIFDYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHM 694

  Fly   502 --------------------------------------------------------DQETR---H 507
                                                                    ..|.|   |
Human   695 HRHPNENTLGKNSFNFSDLNHSKNKVSSEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVH 759

  Fly   508 DFSTVLDDVDELLLKLTQSQPAESKELKAS-----------------------SKLPQI------ 543
            ..::..|:.....||:...:..|.|..|.|                       .||..:
Human   760 SLNSTADESGLNKLKIRYEEFQEHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQP 824

  Fly   544 ----------------------------DGADDRLQRTPIKSISSKSKSSPS------------K 568
                                        ...|:.:|..|..|...|..:..|            |
Human   825 GNKPSRLKLNKRKLAGHQETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENK 889

  Fly   569 TPT-------------------------------------------------------------- 571
            |||
Human   890 TPTDGFIDCHFGDGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGE 954

  Fly   572 ------------------TPI-----------GQKSL---------------------------- 579
                              .|:           |:|::
Human   955 SLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLA 1019

  Fly   580 ------PKSPRTPKTSAAKKYAPLALTIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPE 638
                  ||.|.:|.|    ||....||...|..:||..:.|.:.:..:      |.|....::..
Human  1020 PLKDFWPKVPDSPAT----KYPIYPLTPKKSHRRKSKHKSAKKKTGKQ------QRTNNENIKRT 1074

  Fly   639 ISLRKK----------------------------------------------------------- 644
            :|.|||
Human  1075 LSFRKKRSHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEE 1139

  Fly   645 -LAMSEMRRKSFEDSFVLLKNDCTPVRSTRRSTSNLDKTHIIC---SLTPRDRNPGLSDMFETED 705
             :|.:|.....|:...|..|...:.:..|.|:.:.:.|:....   |:..:.||.........:|
Human  1140 IMAAAEKEAMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKLVDD 1204

  Fly   706 GKQLPPKKVVRKT-------------------------RWSTRNQDIE----------------- 728
            ||:.|..|  :||                         ::..::|::.
Human  1205 GKKKPRAK--QKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQLLFKQKD 1267

  Fly   729 --------------SLPK--------AGC------------------------------------ 735
                          |||.        :||
Human  1268 MPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHPSVVCNSIGPGV 1332

  Fly   736 ---EIERPHRSEGSALDELKP-------------------------------------------- 753
               .::|||..  ||:..||.
Human  1333 SKINVQRPHNQ--SAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGMSSKIEDNANNIQRNYL 1395

  Fly   754 ---------RRSARHKVNSA-NPD---------------ECSSEIQTTGPRVT------------ 781
                     |.|...|::.| .|:               |.|...:|..|..|
Human  1396 SSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSETCSPGNTASEESQMPNNCF 1460

  Fly   782 TTSLDRP-----------------------------------QKKARLSQSPKENTKT------S 805
            .|||..|                                   |.|| |||....|..|      .
Human  1461 VTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKA-LSQCKNRNVSTPSAFGEG 1524

  Fly   806 MNGTVALEK-------------ATKDSSSNSESPHQQENSVSEQIEYLESKPKKSDETA----RS 853
            .:|...|::             .|:|..||.   ||...::|..:|:.::..:....|:    |:
Human  1525 QSGLAVLKELLQKRQQKAQNANTTQDPLSNK---HQPNKNISGSLEHNKANKRTRSVTSPRKPRT 1586

  Fly   854 CDEKLQRELIPQ----------------------EPAGIS-PG-DSANSTEEITFSPCHD----- 889
            .....|:|.||:                      .|...| || :|..|.|: :.||.|:
Human  1587 PRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDSPIFFSDPGFESCYSLED-SLSPEHNYNFDI 1650

  Fly   890 ---------------------------------------EAIESDTESDYIVTKLRKTPNLKR-- 913
                                                   :|||   :::::....:|....|.
Human  1651 NTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIE---KNEFLSHDNQKCDEDKHHT 1712

  Fly   914 ---LRWSIRSELLNKQFTPSSGIRPPETETTPQ-------LSPKSNE--------------SNTP 954
               ..| |||..|:.:....|.|...|.....|       |:.:||.              |...
Human  1713 TDSASW-IRSGTLSPEIFEKSTIDSNENRRHNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKS 1776

  Fly   955 ELMRSFYEHSLIVNSP------------------------SVFSDFLDSP------------EIH 983
            .|.||.....:.::.|                        :.|:..|.||            |::
Human  1777 RLNRSSVSKEVFLSLPQPNNSDWIQGHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELY 1841

  Fly   984 M------------DSPRS-APPSPDSN-SF------VIAPLELPPSYDEVVSGSRKMDIPEYEFQ 1028
            :            .|||| :.||...| ||      ::.||..|||.:|:::.....|:.|..:|
Human  1842 VSRNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLSETIYQ 1906

  Fly  1029 KPYYSNPSDV-SKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRH 1092
            :|:.|||||| .|..|:|..:|.:.....||...|:.....: ||..|:      ....||.|..
Human  1907 EPFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLE-GLRLWK------TAFSAMTQNP 1964

  Fly  1093 R-------GEQKVREYFST------QQRIAIEPAQLAPTWQEAKIWLKAK-ELLRQREEPK---- 1139
            |       |:..|.:..|.      .::|.|.|.:.||:.|..::||:|| |..|.::.||
Human  1965 RPGSPLRSGQGVVNKGSSNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPT 2029

  Fly  1140 ---KSSDDI-------DSPIKIKRQKIT------------------MMLQA-------------- 1162
               ||:::.       |.|:...:..::                  :.|||
Human  2030 GVVKSAENFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQM 2094

  Fly  1163 -------------EEGDGG---------------------------SGDEDAG---EELDC---- 1180
                         |:.|..                           :||:...   |||..
Human  2095 LPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFE 2159

  Fly  1181 --------SLSLTPLSQAKDKCKATPTSSKARETGK-----------------SRLKRGTRLSFI 1220
                    .:..:|.|:.::....:|.:::|| |||                 .||.....||.:
Human  2160 NFLKPIKDGIQKSPCSEPQEPLVISPINTRAR-TGKCESLCFHSTPIIQRKLLERLPEAPGLSPL 2223

  Fly  1221 GSQDEEPPSS----------------QSSEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFG 1269
            .::.:....|                |:..|..:.:..|.|..      |::|.|
Human  2224 STEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETS------QIDGPS---------- 2272

  Fly  1270 LSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAI--E 1332
                 |:||:||||:::|||:|||..:..:||:|::|:...||.||:|||..|.|..|||.|  :
Human  2273 -----LNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSD 2332

  Fly  1333 HSLPD-EKLPSKACGYIMVN---TV--QDLLSEGPF---HGIDRDIEVQVVTSEAEAFEALLALC 1388
            ..||| ||  ::..|.|:::   ||  ||:..:.|.   .|| ..:||.....|...|..:..:.
Human  2333 TPLPDTEK--TELTGVIVIDKDKTVFSQDIRYQTPLLIRSGI-TGLEVTYAADEKALFHEIANII 2394

  Fly  1389 ER--------------------------WDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRV 1427
            :|                          :|.||..||||:|.||||::.||..|..::..::|||
Human  2395 KRGCHQHVRCFQYPHFFYFCKQLRERNMYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRV 2459

  Fly  1428 PTQKVRDFVDEDREQFTDLDV-EMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHT 1491
            |..|:.:....:|:::....: |:.:.|||.|::||:||:|:|||:||||||.:|:||:|.|..|
Human  2460 PDDKIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFT 2524

  Fly  1492 AKSLTEWFGSPCT--RWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFR 1554
            .:.|::||.:...  ||.::::|:.||||.|.:|:||||:|:|||||:|.||||..||:||||:|
Human  2525 FRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYR 2589

  Fly  1555 VESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYN 1619
            |||||||||||.|.:|::||||.|:.||||:.:.|||||:||||::.::||||||||||::||||
Human  2590 VESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYN 2654

  Fly  1620 YCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRML 1684
            ||||||||.||:||....|:||.:.|||...:|.: :.|| :||||.||.|||..||:|:|||||
Human  2655 YCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQ-VRHD-ITVSPNGVAFVKPSVRKGVLPRML 2717

  Fly  1685 TEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSK 1749
            .|||.||.|||||||.:|...||.|:|.:|||||||:||||:|||:||||||||.:|||||:|.|
Human  2718 EEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHK 2782

  Fly  1750 GRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKL 1814
            .|||||||||||.:.::|..|||||||||||||:.|..:.::|:||:|||:|||..||:|||||.
Human  2783 ARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF 2847

  Fly  1815 EKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSK 1879
            ||||.||:||||||||||||||.||:.||::||||||||||.||||:|:||:.|::||||:|:|.
Human  2848 EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISL 2912

  Fly  1880 IKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVP 1944
            ||.||.||..|||.|:|::||.|||||:||...|||.|||||||||||.:..|.|..|:.|||||
Human  2913 IKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVP 2977

  Fly  1945 FIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPR- 2008
            ::|:.|.||:.||:|||.|.::|.:...::||.|||||.|:|||.|...|||.:|..|:..|||
Human  2978 YVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIGIDVFSWYHELPRI 3042

  Fly  2009 -KLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDKT 2072
             |       .|::..:...|.|.||||||:|..|.: |...|:.|||..|........|:|:.:.
Human  3043 HK-------ATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQHGICSKCRSQPQHVAVILNQEI 3099

  Fly  2073 ARLERGYQLTRQICQACCGRLG-SLQCDSLDCPVLYVLEGKRRELQQIEHWNKLLE 2127
            ..|||..:...:||:.|.|... .:.|.||:||||:.|....|||.:..:..:||:
Human  3100 RELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKAPYLRQLLD 3155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301	94/175 (54%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	90/260 (35%)
		POLBc_zeta	1550..2000	CDD:99917	291/449 (65%)
		zf-C4pol	2041..2107	CDD:405022	22/66 (33%)
REV3L	XP_011534330.1	DUF4683	748..1134	CDD:292363	44/395 (11%)
		DNA_polB_zeta_exo	2295..2559	CDD:99821	93/266 (35%)
		POLBc	2317..2818	CDD:214691	260/505 (51%)
		POLBc_zeta	2585..3033	CDD:99917	291/449 (65%)
		DNA_pol_B	2585..3032	CDD:278562	291/448 (65%)
		zf-C4pol	3069..3136	CDD:290959	23/67 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	584	1.000	Domainoid score	I205
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1174	1.000	Inparanoid score	I198
Isobase	1	0.950	-	0	Normalized mean entropy	S3397
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	1	1.000	-	-		oto90299
orthoMCL	1	0.900	-	-		OOG6_102751
Panther	1	1.100	-	-	LDO	PTHR45812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R348
SonicParanoid	1	1.000	-	-		X3116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810