DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and Pold1

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_067694.1	Gene:	Pold1 / 59294	RGDID:	621839	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1039	Identity:	274/1039 - (26%)
Similarity:	438/1039 - (42%)	Gaps:	176/1039 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1160 LQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKC-----------------KATPTSSKARETG 1207
            ||.|.....|.|:..|:||.     .|...|.:.|                 :.|....:.....
  Rat   160 LQRELNAAISRDQRGGKELS-----GPAVLAIELCSRESMFGYHGHGPSPFLRITLALPRLMAPA 219

  Fly  1208 KSRLKRGTRLSFIGSQDEEPPSSQSSEQSVS-----------SSAAQAELDRSSFLRQLEGSSQD 1261
            :..|::|.|:..:|:     ||....|.:|.           ......||....::|:.|..:..
  Rat   220 RRLLEQGIRVPGLGT-----PSFAPYEANVDFEIRFMVDADIVGCNWLELPAGKYVRRAEKKATL 279

  Fly  1262 RQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDE-IR 1325
            .|.::....|........|....:..|:....||:|            :.|..:.|:|..|. |:
  Rat   280 CQLEVDVLWSDVISHPPEGQWQRIAPLRVLSFDIEC------------AGRKGIFPEPERDPVIQ 332

  Fly  1326 CLFYAIEHSLPDE----KLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQVVTSEAEAFEALLA 1386
            .....:....|:.    .|..:.|..|:                  ..:||....|.:..:|...
  Rat   333 ICSLGLRWGEPEPFLRLALTLRPCAPIL------------------GAKVQSYEREEDLLQAWAT 379

  Fly  1387 LCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVP--TQKVRDFVDEDREQFTDLDVE 1449
            .....|.|:..||.|:.....|:|.||:.|..:..|.|.||.  ...:||...:.|:........
  Rat   380 FILAMDPDVITGYNIQNFDLPYLISRAQTLKVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRDSKV 444

  Fly  1450 MKLCGRILLDVWRLMRSEIALTSYTFENVMYHIL--HKRCPWHTAKSLTE-WFGSPCTRWIVMEY 1511
            :.:.||:.:|:.:::..|..|.|||...|.:|.|  .|....|:.  :|: ..|:..||..:..|
  Rat   445 VSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSI--ITDLQNGNEQTRRRLAVY 507

  Fly  1512 YLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQ 1576
            .|:.....|.||::|.:|....|||::.|:....:||||.|.:|.|.:||.|..:.|  |.|.|:
  Rat   508 CLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRGQQVKVVSQLLRQAMREGL--LMPVVK 570

  Fly  1577 ARAHMRAPEYL-ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCL--GRVEHLGGSSPF 1638
            ...   ..:|. |.::||...:|..|:..|||.|||||:::|:|.|::|.|  |..:.||
  Rat   571 TEG---GEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQKLG----- 627

  Fly  1639 EFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKD 1703
                             |:.|....:|.|..|||..||:|:||::|..:|..|:..|  .:|.::
  Rat   628 -----------------LKPDEFIKTPTGDEFVKASVRKGLLPQILENLLSARKRAK--AELAQE 673

  Fly  1704 SSALQR-ILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLV------ 1761
            :..|:| :|..|||.||:..|..||:|.|.. |::|.:|:..||...||:.:|:..:||
  Rat   674 TDPLRRQVLDGRQLALKVSPNSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVETKYTL 737

  Fly  1762 ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTK 1826
            ||..:...:||||||||:.......:.|||..:|.|.|..|:...|.|::|:.||||.|.:|.:|
  Rat   738 ENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYLLISK 802

  Fly  1827 KRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKL 1891
            |||.|.::.:........:.||:|.||||.||.||.::...||.:...:|.....|:.....:.|
  Rat   803 KRYAGLLFSSRSDAHDRMDCKGLEAVRRDNCPLVANLVTSSLRRILVDRDPDGAVAHAKDVISDL 867

  Fly  1892 LSGRANLQDLIFAKE-------FRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVN 1949
            |..|.::..|:..||       :.|...:        :||..:..::||...|..|:|||::|:.
  Rat   868 LCNRIDISQLVITKELTRAAADYAGKQAH--------VELAERMRKRDPGSAPNLGDRVPYVIIG 924

  Fly  1950 GPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNR------------CLLLIGANVHDW 2002
            ...|:........|..:| .....|:..||:.:.:..||.|            .:||.|.:..
  Rat   925 AAKGVAAYMKSEDPLFVL-EHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAESVLLRGDHTR-- 986

  Fly  2003 FASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSC--VIDCGRQTKAGICPDCL-KNATTC 2064
                 .|.::|..||         |..:...:..|...|  |||    .:..:|..|. :.:...
  Rat   987 -----CKTVLTSKVG---------GLLAFTKRRNSCIGCRSVID----HQGAVCKFCQPRESELY 1033

  Fly  2065 VVVLSDKTARLERGYQLTRQICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIEHWNKLLE 2127
            ...:|...|..||..:|..| ||.|.|.| ..:.|.|.|||:.|:.:..|::|:..|   :||:
  Rat  1034 QKEVSHLNALEERFSRLWTQ-CQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQE---RLLQ 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	50/230 (22%)
		POLBc_zeta	1550..2000	CDD:99917	148/478 (31%)
		zf-C4pol	2041..2107	CDD:405022	22/69 (32%)
Pold1	NP_067694.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Nuclear localization signal. /evidence=ECO:0000255	4..17
		PTZ00166	80..1096	CDD:240301	274/1039 (26%)
		DNA_polB_delta_exo	300..529	CDD:99820	58/260 (22%)
		POLBc_delta	575..970	CDD:99916	134/428 (31%)
		zf-C4pol	1008..1078	CDD:290959	23/74 (31%)
		CysB motif	1054..1072		7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820