DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and pole

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001121995.1	Gene:	pole / 553405	ZFINID:	ZDB-GENE-070705-557	Length:	2284	Species:	Danio rerio

Alignment Length:	2370	Identity:	430/2370 - (18%)
Similarity:	739/2370 - (31%)	Gaps:	798/2370 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QKTCMHVHGVFPYLYIPY--DKKDFESLERGILQMAMHLDKAINISL-GQG---SSNAQHVFKIQ 116
            |:...|||...|.:::.|  |..|:..:|....|:.:.:.:.|.... .||   :|.|.|:..::
Zfish   344 QRWFEHVHETKPNIFVTYNGDFFDWPFVEARAAQLGLSMHREIGFQKDNQGEYKASQAIHMDCLR 408

  Fly   117 LVKGIPF--YGYHRVEHQFLKIYMFNP------RFVRRAANLLQSGAILSKNFSPHESHVPYILQ 173
            .||...:  .|.|.::........::|      ...|.|....|:.|..|            :..
Zfish   409 WVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQTLATYS------------VSD 461

  Fly   174 FMIDYNLYGMSYVH---------VPLE---------------VLKFRRNHDDDVIPYANVKQAQ- 213
            .:..|.|| |.|||         :|:|               :|..:..|.:.|.|.   ||.|
Zfish   462 AVATYYLY-MKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHVNIVFPN---KQEQV 522

  Fly   214 ---------LLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSNHTNPGI------------- 256
                     :||..|.......|||..|..:.|..||::         ||..
Zfish   523 FNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFKM---------NPAAFDFLIQRVERTLR 578

  Fly   257 EAIWNDEKLRRQKLVEKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTALESKLMTLE 321
            .||..:||:..:: |....:..||.|.:.:.:.|:|...|...|...:....|...:.:.  .|:
Zfish   579 HAIEEEEKIPLEQ-VTNFNEVCDEIKRKLISLKEVPNRIECPLIYHLDVGAMYPNIILTN--RLQ 640

  Fly   322 QSTLSEQTLSDQTILPQATMQTTMPGTKAQKRRFNLQKLLANAVYP---EECSQDQQQLLVNASF 383
            .|.:.::...       |......||...| ||...|  ....:.|   .|..:.||||
Zfish   641 PSAMVDEATC-------AACDFNKPGANCQ-RRMTWQ--WRGEIMPASRSEFHRIQQQL------ 689

  Fly   384 IQNHVTCGYSSSVSLSTSKDESDDLDETVVDEELILSLTQPHG------AIPHDATLREEDLELL 442
                                ||:......           |:|      .:..:...|.|...|.
Zfish   690 --------------------ESEKFPPVF-----------PNGPPRAFHELNREEQARHEKKRLG 723

  Fly   443 D---------ALQLLEE------QNESESHVDLDSSLAPLSQHKKFELTPELLDKETAATAALFD 492
            |         .|..|||      |.|:..:||                           |...|
Zfish   724 DYCRKAYKKVHLTRLEERVTTICQRENSFYVD---------------------------TVRAF- 760

  Fly   493 EDVDSDEDADQETRHDFSTVLDDVDELLLKLTQSQPAESKELKASSKLPQIDGADDRLQRTPIKS 557
                      ::.|::|..:                  .|..|......|.:|....::|.....
Zfish   761 ----------RDRRYEFKGL------------------HKVWKKKLSTAQDNGDAAEVKRCKNME 797

  Fly   558 ISSKSKSSPSKTPTTPIGQKSLPKSPRTPKTSAAKKYAPLALTIGSSSSKKSND--EFAGRPSNP 620
            |..:|.....|..........:.|..|.    .:.:.|.:....|::...::.:  |..|||
Zfish   798 ILYESLQLAHKCILNSFYGYVMRKGARW----YSMEMAGIVCYTGANIITQARELIEQIGRP--- 855

  Fly   621 RLSLQLDQG----------------TGTGTLRPEISLRKKLAM-SEMRRKSFED-SFVLLKNDCT 667
               |:||..                ..|...:|::::....|| :.|.::.|.: .:..|.:..:
Zfish   856 ---LELDTDGIWCVLPNTFPENFVIKSTNEKKPKVTISYPGAMLNIMVKEGFTNHQYQELVDAAS 917

  Fly   668 PVRSTRRSTS---NLDKTHIICSLTPRDRNPGLSDMFETEDGKQLPPKKVVRKTRWSTRNQDIES 729
            ....||...|   .:|..: :..:.|..:          |:||:|       |.|::..|:|...
Zfish   918 LTYETRAENSIFFEVDGPY-LAMILPASK----------EEGKKL-------KKRYAVFNEDGSL 964

  Fly   730 LPKAGCEIERPHRSEGSALDELKPRRSARHKVNSANPDEC------SSEIQTTGPRVTTTSLDRP 788
            ....|.|::|  |.|...:           |:..::..|.      ..|:..:..:|....||
Zfish   965 AELKGFEVKR--RGELQLI-----------KIFQSSVFEAFLKGTTLEEVYASVAKVADYWLD-- 1014

  Fly   789 QKKARLSQSPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLESKPKKSDETARS 853
                                 |...||.....:.......:..|:|.::|....:...|..||:.
Zfish  1015 ---------------------VLYSKAANMPDAELFELISENRSMSRKLEDYGEQKSTSISTAKR 1058

  Fly   854 CDEKLQRELIPQEPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVTKLRKTPNLKRLRWSI 918
            ..|.|..:::  :.||:|               |.           |::::
Zfish  1059 LAEFLGDQMV--KDAGLS---------------CR-----------YVISR-------------- 1081

  Fly   919 RSELLNKQFTPSSGIRPPETETTPQLSP----KSNESNTPELMRSFYE----HSLIVNSPSVFSD 975
                           :|..:..|.:..|    ::.||.....:|.:.:    |.|.:.|...:|.
Zfish  1082 ---------------KPEGSPVTERAIPLAIFQAEESVKKHFLRKWLKMPSLHDLDIRSILDWSY 1131

  Fly   976 FLDSPEIHMDSPRSAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVSK 1040
            :::.                ..|.:...:.:|.:..:|.:...::..|::..:|....|  |:.|
Zfish  1132 YIER----------------LGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKN--DIYK 1178

  Fly  1041 VTEVGFLVLH----------IPGNKLNDCD-------PFQSILGNDRGLASWRRRQLIAIGGLAM 1088
            ..::..|...          :...:..|.:       |.|..:     |.|.:|::      ::.
Zfish  1179 QKKISELFTSEGKRQVAQQTLAAGETPDMEDLAAPQRPVQPAI-----LISTKRKR------ISQ 1232

  Fly  1089 LQRHRGEQKVREYFSTQQRIAIEPAQLAPTWQEAKIWL----KAKEL-LRQREEPKKSSDDIDSP 1148
            .:..:.|.:.:|...:.:.|...|..:..|.:|..:||    |..|| ||||:|
Zfish  1233 GEDSQTETQEQELTQSWREILGPPPAMGATREEILVWLRYHKKKWELQLRQRKE----------- 1286

  Fly  1149 IKIKRQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKARETGKSRLKR 1213
                |:|...::..|....|.|....|                   ..|...|..|.|.:|.|..
Zfish  1287 ----RRKRRRLIDGESQPTGGGVIRGG-------------------PTTGLGSFLRRTARSILDM 1328

  Fly  1214 GTRL---------------SFIGSQ--------------DEEPPSSQSSEQSVSSSAAQAELDRS 1249
            ..::               :.|||.              ::..|   ..|::.:.......|.||
Zfish  1329 PWQIVQIAETSHPGLYKLWAVIGSDLHCMKLNIPRVFYVNQRVP---KQEEAATCKKVNRILPRS 1390

  Fly  1250 S---FLRQL---EGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVF 1308
            .   ||.|.   |...|:..::::..||...::..:..:|.|  |.:|...:.|  :.::...|.
Zfish  1391 GVACFLYQYTVPEDMYQEHINEINADLSAPDIEGVYETQVPL--LFRALVQLGC--MCMVNKHVV 1451

  Fly  1309 VSTRG------DLQPDPMHDEIRCL-------------FYAIEHSLPDEKL-----PSKACGYIM 1349
            ....|      ||:    |.|:|.|             .|...||...:.|     ||:....|.
Zfish  1452 RDLAGREADTFDLE----HLEMRSLAQFSYLEPGSVRHIYLYHHSQGHKALFGLFIPSQRKASIF 1512

  Fly  1350 V------NTVQDLLSEGPFHGIDRDIEVQVVTS-----EAEAFEALLALCERWDADIYAGYEIEM 1403
            |      |.:.:|.|   .:|.:|...::..|.     |...||.      |.:.||.|.|
Zfish  1513 VLDTVRSNQMPNLNS---LYGAERTALLEKTTEELLPPEKHLFEV------RAENDIKAIY---- 1564

  Fly  1404 SSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQFTDLDVEMKLCGRILLDV---WRLMR 1465
                    ||          |.|:    :.::.:|.|             |..|:.|   |.|.|
Zfish  1565 --------RA----------LQRI----LLNYKEERR-------------GPTLIAVQSNWELRR 1594

  Fly  1466 SEIALT---------SYTFENVMYHILHKRCPW--HTAKSLTEWFGSPCTRWIVMEYYLERVRGT 1519
            ....:|         .:..:.:.|::|    .|  |.|:.:             :::||.
Zfish  1595 LAAGMTVLEEFPVVPVHVIDEISYNVL----DWQRHGARRM-------------IKHYLN----- 1637

  Fly  1520 LTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLR-IAKPKNLVPLSPSVQARAHMRA 1583
               ||  ..|.:..:||:...:....:....|.|..:..:.| :.|..:|:.|||:.:.....:.
Zfish  1638 ---LD--SCLSQAFDMARYYHLPVGNLPQDISIFGSDLFLARHLRKHNHLLWLSPTARPDLGGKE 1697

  Fly  1584 PEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFST-CLGRVEHLGGSSPFEFGASQLRV 1647
            .:...|:||...|               .||.|....|:|| |:            |.....|.|
Zfish  1698 ADDSRLVMESDER---------------GSMEINSQGCYSTVCV------------ELDIQSLAV 1735

  Fly  1648 SRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSAL----Q 1708
            : .:||....:|:...:..||.|      :.|....|.|::...|........  |.:||    .
Zfish  1736 N-TILQSQHVNDMEGGASIGVSF------DVIQHASLEEMMSGNQGANAVASY--DETALCSNTF 1791

  Fly  1709 RILHSRQLG----LKLMANVTYGYTAANFSG--RMPSVEVGDSVVSKGRETLERAI--KLVENNE 1765
            |||.|..:|    :....||.......:|..  |.||..:.|..:.:....:.:.|  :||...:
Zfish  1792 RILKSMVVGWVREITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLLNMMKKIFLQLVAEFK 1856

  Fly  1766 EWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTE--------------------MNPQ-- 1808
            .....|:||:.:.:.:....|...:|....|.|..::..                    |:|.
Zfish  1857 RLGSSVIYGNFNRLILCTKKRRIDDAIAYVEYITNSIHTKEIFHSLSITFSRCWEFLLWMDPANC 1921

  Fly  1809 -PVKLKLEKVYQPCML------QTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLE- 1865
             .||.||     |..|      ..||:..|...:.:|.|.. :|....|...:|....|..::|
Zfish  1922 GGVKGKL-----PSSLLYGEHDSEKKKKDGAEEDGSDDEDE-HEENQEEDEEQDREEDVEDLIES 1980

  Fly  1866 --KVLRILFETQDVSK-----IKAYVCRQFTKLLSG-RANLQDLIFAKEFRGLN--GYKPTACVP 1920
              .:::.|.:|....|     |.||:...:..:... |.|.......|. ||..  ..:|:..|.
Zfish  1981 NWNIMQYLPQTASCQKYFLMIISAYIAAVYHSMRQELRRNAPGATPIKR-RGATQASQQPSGDVS 2044

  Fly  1921 AL-------------ELTRKW------MQK---DPRHVPRRGERVPFIIVNGPPGMQLIRLVRSP 1963
            ||             |||:.:      :||   ..|.|....|..|.:     ||..|  .:.:|
Zfish  2045 ALPGLITFSQEYVSSELTQNFFTITQKIQKKVSSTRSVTLPSEMFPVL-----PGSHL--PLNNP 2102

  Fly  1964 HDILANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANELAGARG- 2027
                     .:..|.|:.:         :|.:.||:.:....|.|.||....||..:|.|..|.
Zfish  2103 ---------ALEFIKYVCQ---------VLSLDANIVNQVNKLKRDLLRLVDVGEFSEDAQFRDP 2149

  Fly  2028 AKSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDKTARLERGYQLTRQICQACCGR 2092
            .||.:........|          ..|.|         :.|....|..:.|..|.:..|..|..:
Zfish  2150 CKSYVLPEVICHHC----------NFCRD---------LDLCKDPAVSQDGSVLPQWFCSNCQAQ 2195

  Fly  2093 LGSLQCDSLDCPVLYVLEGKRRE--LQQIE 2120
            ..:   :|::..::..|:.|...  ||.:|
Zfish  2196 YDT---ESIEMALVEALQKKLMSYTLQDVE 2222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301	36/175 (21%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	51/269 (19%)
		POLBc_zeta	1550..2000	CDD:99917	108/525 (21%)
		zf-C4pol	2041..2107	CDD:405022	10/65 (15%)
pole	NP_001121995.1	PolB	97..1164	CDD:223494	181/1087 (17%)
		DNA_polB_epsilon_exo	267..470	CDD:99822	29/138 (21%)
		POLBc_epsilon	530..1152	CDD:99918	138/873 (16%)
		DUF1744	1527..1924	CDD:285663	96/507 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900