DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and POLA1

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001317289.1	Gene:	POLA1 / 5422	HGNCID:	9173	Length:	1468	Species:	Homo sapiens

Alignment Length:	1588	Identity:	303/1588 - (19%)
Similarity:	546/1588 - (34%)	Gaps:	479/1588 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   767 DEC---SSEIQTTGPRVTTTSLDRPQKKARLSQSPKENTKTSMNGTVALEKATKDSSSNSESPHQ 828
            |:|   :|.:..:|..|::.:  |.:||::..:..            |||: .|.:.:..:..::
Human     7 DDCEIGASALSDSGSFVSSRA--RREKKSKKGRQE------------ALER-LKKAKAGEKYKYE 56

  Fly   829 QEN--SVSEQIEYLESKPKKSDETARSCDEKLQRELIP--QEPAGISPGDSANSTE---EITFSP 886
            .|:  .|.|::                 ||:...:|:.  |:...|...|.....|   ||....
Human    57 VEDFTGVYEEV-----------------DEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDD 104

  Fly   887 CHDEAIESDTESDYIVTKLRKTPNLKRLRWSIRSELLNKQFTPSSG------------------- 932
            ..|:|:::|.:......:.:...|:|:|..: :...:...|...:|
Human   105 LEDDALDADEKGKDGKARNKDKRNVKKLAVT-KPNNIKSMFIACAGKKTADKAVDLSKDGLLGDI 168

  Fly   933 IRPPETETTPQLSPKSNESNTPELMRSFYEHSLIVNSPSVFS----DFLDSPEIHMDSPRSAPP- 992
            ::...|| |||::|       |.:|....:.| |..||:.||    ..:.|.:|.....|..||
Human   169 LQDLNTE-TPQITP-------PPVMILKKKRS-IGASPNPFSVHTATAVPSGKIASPVSRKEPPL 224

  Fly   993 SP---DSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPY-----------------YSNP-- 1035
            :|   ....|....:::..:.:|..||:  |:..:.:|.:|.                 .|.|
Human   225 TPVPLKRAEFAGDDVQVESTEEEQESGA--MEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAE 287

  Fly  1036 -----SDVSKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGE 1095
                 :|..|.| |.:|...:|.....|.|        ..|.:|:..:::........|.:...|
Human   288 EVKQEADSGKGT-VSYLGSFLPDVSCWDID--------QEGDSSFSVQEVQVDSSHLPLVKGADE 343

  Fly  1096 QKVREYFSTQQRIAIEPAQLAPTWQEA---------------KIWLKAKE-------LLRQREE- 1137
            ::|..::                |.:|               |:|:::.|       :::..|.
Human   344 EQVFHFY----------------WLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERT 392

  Fly  1138 ----PKKSSDDID------SPIKIKRQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKD 1192
                |::...|::      :||.:|                    |..||.|        .:...
Human   393 LYFLPREMKIDLNTGKETGTPISMK--------------------DVYEEFD--------EKIAT 429

  Fly  1193 KCKATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDRSSFLRQLEG 1257
            |.|.....||..|.           ::.....:.|..|:..|...|:...|...|       |:|
Human   430 KYKIMKFKSKPVEK-----------NYAFEIPDVPEKSEYLEVKYSAEMPQLPQD-------LKG 476

  Fly  1258 SSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEV--------------- 1307
            .:          .||....||...::.|.|   .|....|      .|||
Human   477 ET----------FSHVFGTNTSSLELFLMN---RKIKGPC------WLEVKSPQLLNQPVSWCKV 522

  Fly  1308 --------FVSTRGDLQPDPM----------------HDEIRCLFYAIEHSLPDEKL---PSKAC 1345
                    .|:...|:.|.|:                .:||..:...:.||...:|.   |....
Human   523 EAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQS 587

  Fly  1346 GYIMVNTVQDLLSEGPFHGI--DRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGY 1408
            .:.:|:..:|.:....|..:  .::::|:|..:|.......||...:.|.||..|:.|    :|
Human   588 HFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNI----YG- 647

  Fly  1409 VIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQFTDLDVEMKL------------CGRILLDVW 1461
                     |.:..||.|:...|...:....|.:.:::.   ||            |||::.||.
Human   648 ---------FELEVLLQRINVCKAPHWSKIGRLKRSNMP---KLGGRSGFGERNATCGRMICDVE 700

  Fly  1462 RLMRSEIALTSYTFENVMYHILHKRCPWHTAKSLTEWFGSPCTRWIVMEYYLERVRGTLTLLDQL 1526
            ...:..|...||....::..||.........:::...:........::|:..:..:..|.::.:|
Human   701 ISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCEL 765

  Fly  1527 DLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYL---- 1587
            ::|....::..:.|......|..|...|.|.::|......|.:     |..:...|.|:..
Human   766 NVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYI-----VPDKQIFRKPQQKLGDE 825

  Fly  1588 ----------------------ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVE 1630
                                  .|:::|:..||...:::|||.|||||:|..:|.||:|    |:
Human   826 DEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTT----VQ 886

  Fly  1631 HLGGSSPFEFGASQLRVSRQMLQKLL---EHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQ 1692
            .:...:                ||:.   |.:.:...|      ...:..|||||.:.::::.|:
Human   887 RVASEA----------------QKVTEDGEQEQIPELP------DPSLEMGILPREIRKLVERRK 929

  Fly  1693 MVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERA 1757
            .|||.||....:..|......||..|||.||..||....::| |..:..:...|..||||.|...
Human   930 QVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYS-RFYAKPLAALVTYKGREILMHT 993

  Fly  1758 IKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCM 1822
            .::|   ::..:.|:||||||:.:.....|..|.|::|.::...|.::. :.:::.::.|::..:
Human   994 KEMV---QKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLY-KLLEIDIDGVFKSLL 1054

  Fly  1823 LQTKKRYVGYMYETADQEQPV--YEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKA-YV 1884
            |..||:|...:.|.......|  .|.||::.||||.|                  |::|... :|
Human  1055 LLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWC------------------DLAKDTGNFV 1101

  Fly  1885 CRQFTKLLSGRA------NLQDLIFAKEFRGLNGYKPTACVPALELTRKWMQKDPRHVP------ 1937
            ..|   :||.::      |:|..:.......|||..|   |...|: .|.:.|||:..|
Human  1102 IGQ---ILSDQSRDTIVENIQKRLIEIGENVLNGSVP---VSQFEI-NKALTKDPQDYPDKKSLP 1159

  Fly  1938 ----------------RRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIP 1986
                            :.|:.|.::|......:...:...:|..:...:...|:..||:.:.|.|
Human  1160 HVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHP 1224

  Fly  1987 PLNR-CLLLIGAN---VHDWFASLPRK--------------LLMTPAVGTANEL----------A 2023
            .:.| |..:.|.:   :..|....|.:              ||..||..|..|.          .
Human  1225 VVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPC 1289

  Fly  2024 GARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDK----------------- 2071
            ...|.::.....|..:...::......:.|  ||..:..|..|.||:|
Human  1290 PTCGTENIYDNVFDGSGTDMEPSLYRCSNI--DCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWL 1352

  Fly  2072 ----------TARLERGYQLTRQICQAC 2089
                      |..|...:..|..:|.||
Human  1353 ICEEPTCRNRTRHLPLQFSRTGPLCPAC 1380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	47/276 (17%)
		POLBc_zeta	1550..2000	CDD:99917	118/513 (23%)
		zf-C4pol	2041..2107	CDD:405022	14/76 (18%)
POLA1	NP_001317289.1	DNA_pol_alpha_N	41..101	CDD:289058	14/77 (18%)
		pol2	56..1231	CDD:273159	265/1371 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..129		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..257		4/20 (20%)
		DNA_polB_alpha_exo	541..773	CDD:99819	43/248 (17%)
		DNA-binding. /evidence=ECO:0000255	656..721		13/67 (19%)
		POLBc_alpha	838..1248	CDD:99915	111/465 (24%)
		DNA-binding. /evidence=ECO:0000255	1251..1382		22/132 (17%)
		zf-DNA_Pol	1271..1461	CDD:286132	19/112 (17%)
		CysB motif. /evidence=ECO:0000250\|UniProtKB:P15436	1354..1380		4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810