DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-zeta and NEXMIF

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001008537.1	Gene:	NEXMIF / 340533	HGNCID:	29433	Length:	1516	Species:	Homo sapiens

Alignment Length:	986	Identity:	198/986 - (20%)
Similarity:	319/986 - (32%)	Gaps:	348/986 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 KVACSALEVDVSSNFILNRFQLVA--------KSKSNHTN---------------PGIEAIWNDE 263
            ||..|...|::|.| .||::..:|        |.|..:||               ||...:....
Human   560 KVDASETTVNLSEN-QLNKYAKLAPLKGFWQKKKKQRNTNTDSIKTPFSQKQSFEPGSFEVSFLP 623

  Fly   264 KLRRQKLVEKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTALESK-----LMTLEQS 323
            ..|::|     :..|:..:.:.:|.:|:..:.:  ||.:....   |.|...|     ..||:.:
Human   624 PARKRK-----SKLGNRHRIQRIPSIEISASSK--QISLCNDQ---RHASNHKEDGGLKGTLKSA 678

  Fly   324 TLSEQTLSDQTILPQATMQTTMPGTKAQKRRFN--LQKLLANAVYPEECSQDQQQ---------- 376
            .|...:.::.:.|...|...::. .|||...|.  .:|:|....:..|.....::
Human   679 PLGAPSCANGSHLNDITGPDSVK-VKAQDTEFKGPERKVLNKIKFKSEARLKSKKVKAAGQESKP 742

  Fly   377 ------LLVNASF---IQNHVTCGYSSSVSLSTSKD----ESDDLDETVVDEELILSLTQ----- 423
                  ||.|.|.   ::|.|..|.|:|..||...:    :|.....|....|:.||...
Human   743 IVQMSPLLENQSSKANLKNEVIPGTSNSSRLSEFHEAKAAKSSTFLPTTCSSEMPLSSANVTTNI 807

  Fly   424 ---PHGAIPHDATLREEDLELLDALQLLE------------EQNESESHVDLDSSLAPLSQHKKF 473
               |.|.:.          .||||..|..            ||||. |....:.|..||...:..
Human   808 PVIPGGYLQ----------TLLDASDLSNNTSISYFSHHSPEQNEG-SLTQTEKSFVPLQPTQDC 861

  Fly   474 ELTPELLDKETAATAALFDEDVDSDEDAD-QETRHDF------------STVLDDVDELLLKLTQ 525
            .||                    |..|:: |::.|:|            :.......|.:.::::
Human   862 VLT--------------------SSSDSELQQSSHNFKMESSNYRNVWPNKATSGTQEFMAEVSR 906

  Fly   526 S-QPAESKELKASSKLPQIDGADDRLQRTPIKSISSKSKSSPSKTPTTPIGQKSLPKSPRTPKTS 589
            . .|.:|.|..||    |:...::.|                  ||||
Human   907 EIAPTQSSEFGAS----QVVSMENNL------------------TPTT----------------- 932

  Fly   590 AAKKYAPLALTIGSSSSKK------------SNDEF-AGRPSNPRLSLQLDQG---TGTGTLRPE 638
                |.|:.|..|.|:..|            |:|.: ....:|..:.....||   ...|.|...
Human   933 ----YNPICLNSGGSNCNKVLYDSMQDTQLPSDDSYQLCHFNNGEICFPFQQGPVNMDDGRLFSF 993

  Fly   639 ISLRKKLAMS-----EMRRKSFE--------DSFVLLKNDCTP----------VRSTRRSTSNLD 680
            .|: ..|::|     .:..||.|        |.|:.   .|:|          :...:.||..||
Human   994 DSM-APLSVSSSNYCSLSLKSCEKDGDDDITDDFLA---HCSPKLVIQQSIDEIAPLKESTDLLD 1054

  Fly   681 KTHIICSLTP-RDRNPGLSDMFETEDGKQLP-----------------------PKKVVRKTRW- 720
                |.:.|| :.|:..||:|...:.....|                       |...|.|.:|
Human  1055 ----ISNFTPDKFRHSSLSEMSPPDTPSLSPQITRCESMKTLGTLKGFQEGVPGPLDSVEKIKWD 1115

  Fly   721 -STRNQDIESLPKAGCEIERPHRSEGSALDELKPRRSARHKVN--------SANPDECSSEIQTT 776
             ||.::.::             ..:|..|:.   .:...|..|        ..||  |.|.....
Human  1116 CSTLSRQVQ-------------MEDGFTLNN---HQFQFHMFNDEDSVSLLQKNP--CLSTFNDP 1162

  Fly   777 GPRVTTTS-LDRPQKKARLSQSPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYL 840
            ..:::|.: :.:.:||:..|:|...|..:|...|  .:|:.|.::...|.|..:.   |.|:
Human  1163 SGQISTNNKVSKSRKKSSPSKSGAMNQSSSQKNT--RKKSLKGNNKGIEKPPGKN---SRQV--- 1219

  Fly   841 ESKPKKSDETARSCDEKLQRELIPQEPAGISPGDSANSTEEI---TFSPC--HDEAIESDTESDY 900
            ....||....|....||:|        .||..|.|..:|...   |.:.|  |...:.|
Human  1220 PKSTKKGKYMAAINGEKMQ--------IGIGRGGSQTNTISSTGKTLAECIQHGGPMAS------ 1270

  Fly   901 IVTKLRKTPNLKRLR--WSIRSELLNKQFTPSSGIRPPETETTPQLSPKSNESNTPELM----RS 959
                 .|.|:.|.|.  |::..                  |::|..|..|..:||..|:    |.
Human  1271 -----MKMPSQKGLSGDWALGK------------------ESSPGWSDMSMGTNTNSLLDDDQRE 1312

  Fly   960 FYEHSLIVNSPSVFSDFLDSPEIHMDS--PRSAPP----------SPDSNSFVIAPLEL-----P 1007
            |.|.|.|::  ::.|...|.....|.|  |...|.          ||:|||..:..|::     .
Human  1313 FQEPSYILS--NIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQ 1375

  Fly  1008 PSYDEVVSGSR 1018
            .|..::.|||:
Human  1376 ESKKKINSGSQ 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821
		POLBc_zeta	1550..2000	CDD:99917
		zf-C4pol	2041..2107	CDD:405022
NEXMIF	NP_001008537.1	DUF4683	284..690	CDD:292363	28/140 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..440
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..610		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1225		14/74 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1373..1419		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930