Protein Alignment DNApol-zeta and Rev3l

DIOPT Version :9

• Sequence 1: NP_524881.2
• Gene: DNApol-zeta / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: XP_006256586.1
• Gene: Rev3l / 309812
• RGDID: 1307087
• Length: 3133
• Species: Rattus norvegicus
• Alignment Length: 3195
• Identity: 898/3195 - (28%)
• Similarity: 1291/3195 - (40%)
• Gaps: 1142/3195 - (35%)

  Fly    11 VYSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPY 75
            ::|||:|.||:||..|..|:|.|.|.|....:|:|||:||||....|||||:|:||||||||:||
  Rat     1 MFSVRIVTADYYMASPLPGLDICQSPLTQHPVKKVPVVRVFGATPAGQKTCLHLHGVFPYLYVPY 65

  Fly    76 DKKDFESLERGILQMAMHLDKAINISLGQGSSNAQHVFKIQLVKGIPFYGYHRVEHQFLKIYMFN 140
            |... :..||.:.|||:.:|:|:|::||..||.||||||:.||.|:||||||..|..|:|||::|
  Rat    66 DGYG-QQPERYLSQMALSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYN 129

  Fly   141 PRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFRR-------N 198
            |..|:|...|||||||::|.:.|||:|:||:||..||||||||:.::  |..:|||:       :
  Rat   130 PAMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLIN--LAAVKFRKARRKGDAS 192

  Fly   199 H---------------------DDDVIPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQ 242
            |                     ::|.||      :.|| :...:.::...||||..:..||||..
  Rat   193 HATGLFKPQLSGNSPAGTLFRWEEDEIP------SSLL-LEGVEPLSTCELEVDAVAADILNRLD 250

  Fly   243 LVAKSKSNHTNPGIEAIWNDEKLRRQKLVE-KHTDAGDEEKAEAVPVLELPPT-QERHQIEIAES 305
            :.|:...   |||::|||.|||.||:...| ......:.:....||..|.... |:|.|..:.::
  Rat   251 IEAQIGG---NPGLQAIWEDEKQRRRNRNENSQISQPESQDCRLVPATESEKIFQKRLQEILKQN 312

  Fly   306 DIFYRT------------------ALESKLMT----------------------------LEQST 324
            |...||                  .|.|::::                            :|::.
  Rat   313 DFSVRTLSGSVDYSSGSQEFSAELTLHSEILSPEMLPCSPANMIEVHRDNDWSKGNTKHKVEEAL 377

  Fly   325 LSEQTL-----SDQTILPQATMQTTMP---------------------GTKAQKRRFNLQK-LLA 362
            ::|:.:     :.||..|.....:..|                     |.:.:|.|..|.: ...
  Rat   378 INEEAILNLIENSQTFQPLTQRLSETPVFMDSSPDESLVHLLAGLESDGYQGEKNRMPLPRHTFG 442

  Fly   363 NAVYPE---------ECSQDQQQLLVNASFIQNHVT---CGYSSSV-----SLSTSKDESDDLDE 410
            .:..|:         :..:::.:|.|..|...:..|   |....|:     ..||.:|:|...:|
  Rat   443 ESQNPQNSDDEENAPQMEKEEMELSVLMSQRWDSDTEEQCAKKRSLCRNAHRSSTEEDDSSSEEE 507

  Fly   411 TV-VDEELI---LSLTQ-------------------PHGAI------------------------ 428
            .. .|..|:   ||:.|                   .|.::
  Rat   508 MEWTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSVFHKDAATLEPPS 572

  Fly   429 --------PHDATLREEDLELLDALQLLEEQNESESHVD------------------LDSSLAPL 467
                    .|.:.|....|...|.::.|.:.|.:|...|                  |.|::...
  Rat   573 SAKITFQCKHTSALSSHGLNKDDLIEGLSQPNNTEKGRDSSVTFTKESTYSMKYSGSLSSTVHSD 637

  Fly   468 SQHKKFELTPELLDKE-----TAATAALFD--EDVDS----------------DEDAD--QETRH 507
            :.||      |:..|:     .:..:::||  ||:.|                ::||.  ...||
  Rat   638 NSHK------EICKKDKSLPVPSCESSVFDYEEDIPSVTRQAPSRKYSNMRKIEKDAPFIHANRH 696

  Fly   508 DFSTVLD-------DVDELLLKLTQ----------------SQPAESKELKAS-----SKLPQID 544
            ...:.|.       |::....||:.                |..|||.:|.:|     |....:|
  Rat   697 TSESTLGKNSFNFADLNHSKNKLSSEGNERGNSTALNSVFPSSLAESCDLLSSSGENRSVAHSLD 761

  Fly   545 GADDRLQRTPIK--------------SIS--------------SKSKSSPSKTPTTPIGQKSLPK 581
            ...|...|:.:|              |:|              |...:.|.|  .:|:..|..|.
  Rat   762 SITDESGRSKLKIRYEEFQEHKMERPSLSQQAAHYMFFPSVVLSNCLTRPQK--LSPVTYKLQPG 824

  Fly   582 SPRTPKTSAAKKYAPLALTIGSSSSKKS-----------NDEFAGRPSNPR-LSLQLDQGT---- 630
            |    |||..|......:::..:|:|.|           |..::|.|.... ||..|.:.|
  Rat   825 S----KTSRLKLNKKKLISLQETSTKSSETGAAKDSCTHNHPYSGTPEKESGLSSDLIKATHGTF 885

  Fly   631 --------------GTGTLRPEISL---RKKLAMSEMRRKSFE----DSFVLLKNDCTPVRSTRR 674
                          |.|:|..|.|.   ..|..:...|:.::|    :|..:..|....:.....
  Rat   886 ENKTPTEHFIDCHFGDGSLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPME 950

  Fly   675 STSNLDKT-------------------HIICSLTPRDRNP----GLSDMFE-----TEDGKQLPP 711
            ...|||.|                   :||.:.....:|.    |..|..|     ||:..:|..
  Rat   951 IGENLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYK 1015

  Fly   712 KKVVRKTRW-------STRNQDIESLPKAGCEIERPHRS--------EGSALDELKPRRSARHK- 760
            |....|..|       :|:.......||.....:..|:|        ..::.:.:|...|.|.|
  Rat  1016 KLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKRKPGKQHRASSENIKRTLSFRKKR 1080

  Fly   761 ----------------------------------------VNSANP------DECSSEI------ 773
                                                    |||:.|      |..:.||
  Rat  1081 THAVLSPPSPSYIAETEDCDLNYSDVMSKLGFLSERSTSPVNSSPPRCWSPTDPRAEEIMAAAEK 1145

  Fly   774 -------------QTTGPRV--------------------------------TTTSLDRPQKKAR 793
                         :|..|||                                |...:|..:||.|
  Rat  1146 ESVLFKGPNVCNTKTVSPRVGKASRARAQVKKSKARLAKSSVVTNKRNKRNQTNQLVDNGKKKPR 1210

  Fly   794 LSQSPKENTK-TSMNGTVALEKATKDSSSNSESPHQQ---ENSVSEQIEYLESKPKKSDETARSC 854
            ..|..:.|.| .|....:..::.||..|....:|.|:   |.:.|..|..| ||.|:..:|..:.
  Rat  1211 AKQKQRANEKGISRKPVIPTDETTKPPSEAELTPSQRSVPELTSSSGIHTL-SKQKEMTQTGPAM 1274

  Fly   855 DEKLQRELIPQEPAGI---------------------------SPGDSANS-------------- 878
            |..|.    |.:|.||                           |.|||.:|
  Rat  1275 DHPLP----PCQPTGINAQQRLSNCFSSFLESRKSVQFPTFPSSRGDSRSSVYSSIGPGVSKVNT 1335

  Fly   879 ----------------------------------------------TEEIT-------------- 883
                                                          |||.:
  Rat  1336 QRSHSQSAMFTRKETTLIQKSIFDLSNHLSQVAQSTQLCSGIISPKTEESSNTQKNCGSSIGKLN 1400

  Fly   884 -----------------FSPCHDE----------------------AIESDTESDYIVTKLRKTP 909
                             |..|.|.                      |.|.....:..||.||..
  Rat  1401 EYRSSLESKPEKVCAPNFLHCRDSQQQTVNVSEQSKPSETCSPGNAASEESQTPNCFVTSLRSP- 1464

  Fly   910 NLKRLRW-------------------------------------------------------SIR 919
             :|::.|                                                       ::.
  Rat  1465 -IKQITWEQRQRGCILEMSSFKPEKVKQRSLSEAISQTKALSQCKNQNVSTPSVFGEGQSGLAVL 1528

  Fly   920 SELLNK-----QFT------------------------------------PSSGIRPPETETTPQ 943
            .|||.|     |.|                                    |.:..|....|.||:
  Rat  1529 KELLQKRQQKAQTTNVQDSASSHQPDKDISVSAEHKKTNKRTRAVASPRKPRAPRRTKPKEQTPR 1593

  Fly   944 -----------------------------------------LSPKSN------------------ 949
                                                     |||:.|
  Rat  1594 RLKVDPLNLQTSGHLDNSLSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSLYS 1658

  Fly   950 -----------------------------ESN-----------------------------TPEL 956
                                         |.|                             .|||
  Rat  1659 GSQFVPADQNLPQKFLSDAVQDLFPGQAIEKNELLSHDRQSCTEEKHHVSDSGPWVRASTLNPEL 1723

  Fly   957 MR-----------------SFYEHSLIVNSPSVFSDF---------------------------- 976
            ..                 ||  |.|..:|.|:...|
  Rat  1724 FEKVGIDNNENHRHSQWKTSF--HPLTSHSNSIMESFCVQQAESCLPEKSRLNRSSVSKEVFLSL 1786

  Fly   977 --------------------LDSPEIHMDSPRSAP------------------------PSPDSN 997
                                |||......:..|:|                        |:|||:
  Rat  1787 PQASSSDWIQGHNGKEIEQSLDSANTSFTTVLSSPDGELVDAASEDLELYVSRNNDVLTPTPDSS 1851

  Fly   998 -------------SF------VIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDV-SKVT 1042
                         ||      ::.||..|||.:|:|:.....|:.|..:|:|:.|||||| .|..
  Rat  1852 PRSTSSPLQSKNGSFTPRTAHILKPLMSPPSREEIVATLLDHDLSEAIYQEPFCSNPSDVPEKPR 1916

  Fly  1043 EVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHR-------GEQKVRE 1100
            |:|..:|.:.....||...|:.....: ||..|:      ....||.|..|       |...|.:
  Rat  1917 EIGGRLLMVETRLPNDLIEFEGDFSLE-GLRLWK------TAFSAMTQNPRPGSPLRNGPAVVNK 1974

  Fly  1101 YFST------QQRIAIEPAQLAPTWQEAKIWLKAK-ELLRQREEPK-------KSSDDI------ 1145
            ..|.      .::|.|.|.:.||:.|..:.||:|| |.:|.:..|:       ||:|::
  Rat  1975 ESSNSHKTVEDKKIVIMPCRYAPSRQLVQAWLQAKEEYVRSKRLPRTESTPVIKSADNVSPSLNP 2039

  Fly  1146 -----------------DSPIKIKRQKITMMLQAEEGDGGSG----------------------- 1170
                             .|....|.:.....:..:....|.|
  Rat  2040 GDTRAVAPQMDTCPHTLSSTAHAKEEVCQSQIALQTSRTGCGQTVSASQTLLPAASAAVPEEEEE 2104

  Fly  1171 --DEDAGEELD----------CSLSLTPLSQA----------KDKCKATPTS---SKARETGKSR 1210
              :|:..||.|          .|..:.|..||          :.:| ::|..   |:|.|.....
  Rat  2105 EEEEEEEEEEDENGYVSYSSPDSPGIPPWQQAASPDFRALNGEHRC-SSPVEELCSRAVENFLKP 2168

  Fly  1211 LKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDR-------------SSFLRQL------- 1255
            :|.|.:           .:|....|.:|...|:...::             ..||.:|
  Rat  2169 IKDGIQ-----------KASCCESQVISPIHARTRTEKCEPLCLHSTPVMPRKFLEKLPEATGLS 2222

  Fly  1256 --------------EGSSQDR--------QHDLSFG-----------LSHATLDNTFGFKVNLEN 1287
                          :||..|.        |.:..|.           :...:|:||:||||:::|
  Rat  2223 PLSVEPKTQKLYNKKGSDTDHLRRVLLTTQVENQFAAVNTPKKETSQIDGPSLNNTYGFKVSIQN 2287

  Fly  1288 LQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAI--EHSLPD-EKLPSKACGYIM 1349
            ||:|||..:..:||:|::|:...||.||||||..|.|..|||.|  :..||| ||  ::..|.|:
  Rat  2288 LQEAKALHEIQNLTLISVELHARTRRDLQPDPEFDPICALFYCISSDTPLPDTEK--TELTGVIV 2350

  Fly  1350 VN-----TVQDLLSEGPF---HGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSW 1406
            ::     |.||:..:.|.   .|: ..:||.....|...|:.:..:.:|:|.||..||||:|.||
  Rat  2351 IDKDKTVTHQDIRCQTPLLIRSGV-TGLEVTYAADEKALFQEVTNIMKRYDPDILLGYEIQMHSW 2414

  Fly  1407 GYVIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQF-TDLDVEMKLCGRILLDVWRLMRSEIAL 1470
            ||::.||..|..::..::||||..|:.:....:|:.: :|...|:.:.|||.|::||:||:|:||
  Rat  2415 GYLLQRAAALSVDLCQMISRVPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVAL 2479

  Fly  1471 TSYTFENVMYHILHKRCPWHTAKSLTEWFGSPCT--RWIVMEYYLERVRGTLTLLDQLDLLGRTS 1533
            |:||||||.:|:||:|.|..|.:.|::||.:...  ||.::::|:.||||.|.:|:||||:|:||
  Rat  2480 TNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTS 2544

  Fly  1534 EMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFY 1598
            |||:|.||||..||:||||:||||||||||||.|.:|::||||.|:.||||:.:.|||||:||||
  Rat  2545 EMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPESRFY 2609

  Fly  1599 ADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTV 1663
            ::.::||||||||||::||||||||||||.:|:||....|:||.:.|||...:|.: :.|| :||
  Rat  2610 SNSVLVLDFQSLYPSIVIAYNYCFSTCLGHIENLGKYDEFKFGCTSLRVPPDLLYQ-IRHD-ITV 2672

  Fly  1664 SPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGY 1728
            ||.||.|||..||:|:|||||.|||.||.|||||||.::...||.|:|::|||||||:||||:||
  Rat  2673 SPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYRQDRALSRMLNARQLGLKLIANVTFGY 2737

  Fly  1729 TAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFR 1793
            |:||||||||.:|||||:|.|.|||||||||||.:.::|..|||||||||||||:.|..:.::|:
  Rat  2738 TSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFK 2802

  Fly  1794 IGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCP 1858
            ||:|||:|||..||:|||||.||||.||:||||||||||||||.||:.||::||||||||||.||
  Rat  2803 IGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCP 2867

  Fly  1859 AVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVPALE 1923
            ||:|:||:.|::||||:|:|.||.||.||..||:.|:|::||.|||||:||...|:|.|||||||
  Rat  2868 AVSKILERSLKLLFETRDISLIKQYVQRQCMKLVEGKASIQDFIFAKEYRGSFSYRPGACVPALE 2932

  Fly  1924 LTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPL 1988
            ||||.:..|.|..||.|||||::||.|.||:.||:|:|.|.::|.:...::||.|||||.|:|||
  Rat  2933 LTRKMLAYDRRSEPRVGERVPYVIVYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPL 2997

  Fly  1989 NRCLLLIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGRQTKAGI 2053
            .|...|||.:|..|:..|||     ....|::..:...|.|.||||||:|..|.: |...|:.||
  Rat  2998 ARIFSLIGIDVFSWYQELPR-----IQKATSSSRSDLEGRKGTISQYFTTLHCPV-CDGLTQHGI 3056

  Fly  2054 CPDCLKNATTCVVVLSDKTARLERGYQLTRQICQACCGRLG-SLQCDSLDCPVLYVLEGKRRELQ 2117
            |..|........::|:.:...|||..:...:||:.|.|... .:.|.||:||||:.|....|||.
  Rat  3057 CSQCRSQPQHVAIILNQEIRELERQQEQLVKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNRELS 3121

  Fly  2118 QIEHWNKLLE 2127
            :..:..:||:
  Rat  3122 KAPYLRQLLD 3131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301	96/175 (55%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	90/234 (38%)
		POLBc_zeta	1550..2000	CDD:99917	288/449 (64%)
		zf-C4pol	2041..2107	CDD:405022	21/66 (32%)
Rev3l	XP_006256586.1	DUF4683	747..1133	CDD:292363	68/391 (17%)
		DNA_polB_zeta_exo	2297..2535	CDD:99821	93/240 (39%)
		POLBc_zeta	2561..3009	CDD:99917	288/449 (64%)
		DNA_pol_B	2561..3008	CDD:278562	288/448 (64%)
		zf-C4pol	3045..3112	CDD:290959	22/67 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	584	1.000	Domainoid score	I198
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1195	1.000	Inparanoid score	I178
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	1	1.000	-	-		oto97421
orthoMCL	1	0.900	-	-		OOG6_102751
Panther	1	1.100	-	-	LDO	PTHR45812
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3116
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830