DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and Pole

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001100622.2	Gene:	Pole / 304573	RGDID:	1594540	Length:	2283	Species:	Rattus norvegicus

Alignment Length:	1621	Identity:	299/1621 - (18%)
Similarity:	513/1621 - (31%)	Gaps:	543/1621 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   691 RDRNPGLSDMFETEDG--KQLPPKKVVRKTRWSTRNQDI----ESLPKAGCEIERP------HRS 743
            |...||.......:||  ..:...|.:.:::| |...|:    |.|.:.|   ||.      |.:
  Rat     9 RHPEPGADSEGSRDDGPSSSVSALKRLERSQW-TDKMDLRFGFERLKEPG---ERTGWLINMHPT 69

  Fly   744 EGSALDELKPRRSA-----------RHKVNSANPDE----------CSSEIQTTGPRVTTTSLDR 787
            |  .|||.|...||           |.||  |.|.:          |..|:.      :..|...
  Rat    70 E--ILDEDKRLVSAVDYYFIQDDGSRFKV--ALPYKPYFYIAARKGCDREVS------SFLSKKF 124

  Fly   788 PQKKARLSQSPKEN--------------TKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIE 838
            ..|.|:|...|||:              .|.|.:....|.|..|:.|...:...:|:::..|...
  Rat   125 QGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTT 189

  Fly   839 YLESKPKKSDETARSCDEKLQRELIPQEPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVT 903
            .|.|                           |..|.|..:.||.|.....|:........:|.|.
  Rat   190 MLSS---------------------------ILQGGSLITDEEETSKKIADQLDNIVDMREYDVP 227

  Fly   904 -KLRKTPNLK---------RLRWSI-------RSELLNKQFTPSSGIRPPETETTPQLSPKSNES 951
             .:|.:.:|:         |.|.:.       |.:|:.:   |...:...:.||| :|..|..::
  Rat   228 YHIRLSIDLRIHVAHWYNVRFRGNAFPVEIARRDDLVER---PDPVVLAFDIETT-KLPLKFPDA 288

  Fly   952 NTPELMRSFY----EHSLIVNSPSVFSDFLD---SPEIHMDSPRSAPPSPDSNSFVIAPLELPPS 1009
            .|.::|...|    :..||.|...|..|..|   :|:...:.|......||.       :.|...
  Rat   289 ETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDE-------VHLIQR 346

  Fly  1010 YDEVVSGSRKMDIPEYE---FQKPYYSNPSDV---SKVTEVGF-----------LVLHIPGNKLN 1057
            :.|.:..::...:..|.   |..|:....:.:   |...|:||           ..:|:
  Rat   347 WFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHM------ 405

  Fly  1058 DC------DPFQSI------------LGND-----------------RGLASWRRRQLIAIGGLA 1087
            ||      |.:..:            ||.|                 :.||::.....:|...|.
  Rat   406 DCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLY 470

  Fly  1088 MLQRHRGEQKVREYFSTQQRIAIEPAQL----APTWQEAKIWLKA--KELL---RQREEPKKSSD 1143
            |...|      ...|:....|.:||.::    :.|..||.:.::|  ..::   :|.:|..|.:|
  Rat   471 MKYVH------PFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTD 529

  Fly  1144 DIDSPIKIKRQKITMMLQAEEGDGGSGDE-DAG---EELDCSLSLTP-----LSQAKDKCKATPT 1199
            |            ..:|.||...||..:. ::|   .::.|...:.|     |.|..:|     |
  Rat   530 D------------GHVLDAETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEK-----T 577

  Fly  1200 SSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSSE-QSVSSSAAQAELDRSSFLRQLEGSSQDRQ 1263
            ...|.|                 ::|:.|..|::. |.|...
  Rat   578 MRHAIE-----------------EEEKVPVEQATNFQEVCEQ----------------------- 602

  Fly  1264 HDLSFGLSHATLDNTFGFKVNLENLQQAKADIDC---NHLTIITLEVFVSTRGDLQPDPMHDEIR 1325
                             .|..|.:|:.....|:|   .||.:..:...:.....|||..:.||..
  Rat   603 -----------------IKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEAT 650

  Fly  1326 CL------------------------------FYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEG 1360
            |.                              ::.|:|.|..||.|             .|..||
  Rat   651 CAACDFNKPGATCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFP-------------PLFPEG 702

  Fly  1361 P---FHGIDRDIEVQVVTSEAEAFE--ALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNI 1420
            |   ||.:.|:        |...:|  .|...|.:      |..:|.|:.   |.:|...:|
  Rat   703 PARAFHELSRE--------EQAKYEKRRLADYCRK------AYKKIHMTK---VEERLTTIC--- 747

  Fly  1421 APLLSRVPTQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFE-------NV 1478
                     |:...|..:....|.|...|.|  |  |..||:...|.........|       .:
  Rat   748 ---------QRENSFYVDTVRAFRDRRYEFK--G--LHKVWKKKLSAAVEVGDASEVKRCKNMEI 799

  Fly  1479 MY---HILHKRCPWHTAKSLTEWFG---SPCTRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAK 1537
            :|   .:.|| |      .|..::|   ....||..||      ...:......:::.:..|:.:
  Rat   800 LYDSLQLAHK-C------ILNSFYGYVMRKGARWYSME------MAGIVCFTGANIITQARELIE 851

  Fly  1538 LIGIQFYEVLSRGSQFRVESM--MLRIAKPKNLVPLSPSV-QARAHMRAPEYLALIM-------- 1591
            .||        |..:...:.:  :|..:.|:|.|..:.:| :.:..:..|..:..||
  Rat   852 QIG--------RPLELDTDGIWCVLPNSFPENFVIKTTNVKKPKLTISYPGAMLNIMVKEGFTNH 908

  Fly  1592 ------EPQSRFY---ADPLIVLDFQSLYPSMIIAYN----------YCFSTCLGRVEHLGGSSP 1637
                  ||.|..|   ::..|..:....|.:||:..:          |......|.:..|.|
  Rat   909 QYQELTEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKG--- 970

  Fly  1638 FEFGASQLRVSRQMLQKLLEHDLVTVSPCGV--VFVKREVREGI---LPRMLTEILDTRQMVKQS 1697
            ||            :::..|..|:.:....|  .|:|....|.:   :.::....||.......:
  Rat   971 FE------------VKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAAN 1023

  Fly  1698 MKLHKDSSALQRILHSRQLGLKL-------MANVTYGYTAANFSGRMPSVEVGDS---VVSK--- 1749
            |   .||...:.|..:|.:..||       ..:::.....|.|.|.....:.|.|   ::|:
  Rat  1024 M---PDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPE 1085

  Fly  1750 GRETLERAIKLV-------------------ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIG 1795
            |....||||.|.                   .:.:::.:|.:. |.|....           |:|
  Rat  1086 GSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRTIL-DWDYYIE-----------RLG 1138

  Fly  1796 EEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETV-----RRD 1855
            ..|.|.:|      :...|::|..|.   .:.::..::::...::..:|:.|.|..:     :|.
  Rat  1139 SAIQKIIT------IPAALQQVKNPV---PRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQ 1194

  Fly  1856 GCPAVAKMLEKVLRILF-ETQDVSKIKAY-----VCRQFTKLLSGRANLQDLIFAKEFRGLNGYK 1914
              ..:|:..|..|.:.. :.:|....|.|     |..:..::...:...||:.....::.:.|..
  Rat  1195 --IVMAQASENSLSLCTPDMEDFGLTKPYHSTVPVATKRKRVWESQKESQDITLTVPWQEVLGQP 1257

  Fly  1915 PTACVPALEL-------TRKWMQKDPRHVPRR-------GERVPFI--IVNGPP---GMQLIRLV 1960
            |:......|.       .:||..:..:.:.||       .|.:|.:  |..||.   |..|.|..
  Rat  1258 PSLGTTQEEWLVWLQFHKKKWQLQAQQRLARRKKQRLESAEDMPRLGAIREGPATGLGSFLRRTA 1322

  Fly  1961 RSPHDILANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANE 2021
            ||..|:...       |..|::.....|.|...:||:::|....|:||...:...|..|.:
  Rat  1323 RSIMDLPWQ-------IIQISETRQAGLFRLWAIIGSDLHCIKLSIPRVFYVNQRVAKAED 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	54/271 (20%)
		POLBc_zeta	1550..2000	CDD:99917	97/546 (18%)
		zf-C4pol	2041..2107	CDD:405022
Pole	NP_001100622.2	PolB	99..1165	CDD:223494	230/1301 (18%)
		Lyase_I_like	<125..>231	CDD:294018	25/132 (19%)
		DNA_polB_epsilon_exo	268..471	CDD:99822	38/216 (18%)
		POLBc_epsilon	531..1153	CDD:99918	139/786 (18%)
		DUF1744	1528..1924	CDD:285663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900