DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and rev3

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_594068.1	Gene:	rev3 / 2543358	PomBaseID:	SPAC688.10	Length:	1480	Species:	Schizosaccharomyces pombe

Alignment Length:	2135	Identity:	541/2135 - (25%)
Similarity:	808/2135 - (37%)	Gaps:	753/2135 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DPCYSELRGK-------EIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPYDKKDF-ESLERGI 87
            ||.| :..||       |:..||||||||.|...:..|..:|.||||:|:.|  ..| |:|:..:
pombe    16 DPAY-DFVGKDLPTANEELTTVPVIRVFGLNEEAETVCCFIHNVFPYIYVEY--SSFAETLDLEV 77

  Fly    88 LQMAMHLDKAINISLGQGSSNAQHVFK-----IQLVKGIPFYGYHRVEHQFLKIYMFNPRFVRRA 147
            ......|..:||.:|...:......:|     :|||||||||||.....:||||.:|:|:...|.
pombe    78 PDFLSQLQTSINYALALAARANPETYKPAVQSVQLVKGIPFYGYSFCFQKFLKICLFSPKNRDRL 142

  Fly   148 ANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFRRNHDDDVIPYANVKQA 212
            .:|.:.||||:|....:|||:||:||||:|:||||.:.:.:...::|     .||::.:.||
pombe   143 VDLFRQGAILNKVIQVYESHLPYLLQFMVDHNLYGCAPIDLDDSIIK-----RDDLLSFCNV--- 199

  Fly   213 QLLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSNHTNPGIEAIWNDEKLRRQKLVEKHTDA 277
                            ||.||.|.|||                  |.|..|:       ..|||
pombe   200 ----------------EVHVSPNAILN------------------ACWLSER-------NIHTD- 222

  Fly   278 GDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTALESKLMTLEQSTLSEQTLSDQTILPQATMQ 342
                                          .|.|...|                     |.:.:.
pombe   223 ------------------------------LYETHASS---------------------PNSLLV 236

  Fly   343 TTMPGT-KAQKRRFNLQKLLANAVYPEECSQDQQQLLVNASFIQNHVTCGYSSSVSLSTSKDESD 406
            |::... |::..|.||                                          ||.||::
pombe   237 TSLAEIWKSEASRRNL------------------------------------------TSSDETN 259

  Fly   407 DLDETVVDEELILSLTQPHGAIPHDATLREEDLELLDALQLLEEQNESESHVDLDSSLAPLSQHK 471
            ...:                       |.:....|.:     |..:|..|           |||.
pombe   260 SFSK-----------------------LHQSQFGLKE-----ESSHEPRS-----------SQHW 285

  Fly   472 KFELTPELLDKETAATAALFDEDVDSDEDADQETRHDFSTVLDDVDELLLKLTQSQPAESKELKA 536
            |.|:.                                       :.:||..|.
pombe   286 KNEVA---------------------------------------MKDLLKNLI------------ 299

  Fly   537 SSKLPQIDGADDRLQRTPIKSISSKSKSSPSKTPTTPIGQKSLPKSPRTPKTSAAKKYAPLALTI 601
                                    |||...|....||:.....|:.|........|.|.
pombe   300 ------------------------KSKLESSSDVNTPLIFDPWPELPTIYSAIHTKDYV------ 334

  Fly   602 GSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPEISLRKKLAMSEMRRKSFEDSFVLLKNDC 666
                          |||...:|:.            :||:.:|:                    |
pombe   335 --------------RPSQNDISVS------------QISVDEKI--------------------C 353

  Fly   667 TPVRSTRRSTSNLDKTHIICSLTPRDRNPGLSDMFETEDGKQLPPKKVVRKTRWSTRNQDIESLP 731
            |       |..:|.|..:     .::..|.:...||..|.
pombe   354 T-------SYESLPKIQL-----EQNTAPVIESSFEQLDS------------------------- 381

  Fly   732 KAGCEIERPHRSEGSALDELKPRRSARHKVNSANPDECSSEIQTTGPRVTTTSLDRPQKKARLSQ 796
                |:|   |..|..|.:..|                          ....::||       |:
pombe   382 ----ELE---RILGDTLFDSFP--------------------------YVEPNVDR-------SK 406

  Fly   797 SPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLESKPKKSDETARSCDEKLQRE 861
            .||....:|       ::.|..||.:.:||              .|.|.|.          :..:
pombe   407 FPKSPLNSS-------QEVTIHSSQDRQSP--------------PSSPLKD----------VPSQ 440

  Fly   862 LIPQEPAGISPGDSANSTEEITF------SPCHDEAIESDTESDYIVTKLRKTPNLKRLRWSIRS 920
            :.|..|:....|.|..:..||.|      .|...|..:.||         ||..  |||::|
pombe   441 INPFSPSLRLKGGSPITKREIEFCRDLPNRPTSSEPNQGDT---------RKAG--KRLKYS--- 491

  Fly   921 ELLNKQFTPSSGIRPPETETTPQLSPKSNESNTPELMRSFYEHSLIVNSPSVFS-DFLDSPEIHM 984
                                                 |:..::.:....|..:| .||...|
pombe   492 -------------------------------------RNLDDYHICTQIPEDYSPKFLSQHE--- 516

  Fly   985 DSPRSAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKP---YYSNPSDVSKVTEVGF 1046
                         |||..  :.|||.|::....:|:.||   |..|   :||:..|:...::...
pombe   517 -------------SFVYK--QQPPSTDDLYGTMKKLKIP---FSIPTNVHYSSEKDIPSYSQEYL 563

  Fly  1047 LVLHIP-GNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAI 1110
            ...|.| |........|||                   .|                 |..:::.:
pombe   564 GKSHYPIGVSSRYLPEFQS-------------------DG-----------------SVSEKVRL 592

  Fly  1111 EPAQLA-----PTWQEAKIWLKAKEL---LRQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDG 1167
            .|.:|:     .|||    ::|...|   |...|..:..|::|.||.::.|.|:
pombe   593 NPLKLSNFHGERTWQ----YIKPAPLAVDLSNLESKEAVSEEIQSPQRLSRSKV----------- 642

  Fly  1168 GSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQS 1232

pombe   643 ----------------------------------------------------------------- 642

  Fly  1233 SEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDC 1297
                                                            |:         |....|
pombe   643 ------------------------------------------------FR---------KDPYSC 650

  Fly  1298 NHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEGPF 1362
              :.|:.||:|..:.|.|.|||..|.|.|.|:|.:..:....:  ...|:|:|:   ...|...|
pombe   651 --VRILALELFCCSHGGLTPDPTKDSIECCFWAYQEDVNSSMI--DRVGFIVVD---KSASNSSF 708

  Fly  1363 HGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKH-LCFNIAPLLSR 1426
            ........|.||.||.|....::.|..:.|..|..|||:..|||||:|:||.: ..:::...|||
pombe   709 GRSFPSCTVLVVNSELELINEVIGLNRQLDPTIVCGYEVHNSSWGYLIERASYRFNYDLPEQLSR 773

  Fly  1427 VPTQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHT 1491
            :......:|..::..........:.:.||.:|::||::|.|:.|.:|:.|||:.:|..|:.|::.
pombe   774 LKCTSKANFAKKENAWKYTTTSSINIVGRHVLNIWRILRGEVNLLNYSLENVVLNIFKKQTPYYN 838

  Fly  1492 -AKSLTEWFGSPC-TRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFR 1554
             |..:..|..|.. .:.|::.|.|.|.|..|.:|....::.:..|.|::|||.|..|:||||||:
pombe   839 QADKVHLWQSSRFHEKQILLNYMLNRTRYCLEILSACAIVTKIREQARIIGIDFMSVISRGSQFK 903

  Fly  1555 VESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYN 1619
            |||:|.|||||:|.:..|||.:..|...|.|.|.|:|||:|..|.:|::||||||||||:|||||
pombe   904 VESIMFRIAKPENYIFPSPSAKQVAEQNALEALPLVMEPKSDLYNNPVVVLDFQSLYPSIIIAYN 968

  Fly  1620 YCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRML 1684
            .|:|||||.|:.:.|.....|   ....|...:..|:::| |.:||.|..:||..||:.:|.:||
pombe   969 LCYSTCLGPVKIVNGKVKLGF---MFHSSNPNIVNLIKND-VYISPNGYAYVKENVRKSLLAKML 1029

  Fly  1685 TEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSK 1749
            .|:::||.|||:.|| ..||..:.::|:||||.|||:||||||||:|:||||||..|:.|::|..
pombe  1030 EELIETRNMVKRGMK-DCDSDYVNKVLNSRQLALKLIANVTYGYTSASFSGRMPCSEIADTIVET 1093

  Fly  1750 GRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKL 1814
            |||.|..:::.:...:....:||||||||:||.:||..:.:||.||:::|..:|...|.|::||.
pombe  1094 GREILSYSLEYINTLDFCHAKVVYGDTDSLFVELPGATKEQAFDIGQQLANNITSRFPSPIRLKF 1158

  Fly  1815 EKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSK 1879
            ||:|.||.|..||||||:.:|:..|:.|::||||||||||||.|...::|.:.|.|||:|:|:|.
pombe  1159 EKIYFPCFLLAKKRYVGFKFESVSQKAPIFEAKGIETVRRDGTPVQQQLLRRCLEILFKTKDLST 1223

  Fly  1880 IK---AYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKP-TACVPALELTRKWMQKDPRHVPRRG 1940
            :|   ..||.|   ::||...:.|..|:||.| |..||. :...|...:.|:.|.||||..|:.|
pombe  1224 VKKEFQNVCYQ---IMSGNVPVMDFCFSKEVR-LEKYKELSTAPPGAVMARRLMTKDPRREPQYG 1284

  Fly  1941 ERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFAS 2005
            ||||::|:...||..|.....:|.:.|::...:::..|||..::||||:|.|.|:||:...|:..
pombe  1285 ERVPYLIIAAAPGTTLANRSVAPEEFLSSSFSQLDINYYINNSLIPPLDRFLNLLGASAQSWYHE 1349

  Fly  2006 LPR---KLLMTPAVGTANELAGARGA--KSTISQYFS---TTSCV---IDCGRQTKAGICPDCLK 2059
            :|:   .|.:|..|         :|.  |.|:..:..   .:||:   |:........:|.||||
pombe  1350 MPKPRTSLKLTETV---------KGGIQKKTLDTFLMEKLCSSCLKNNIEIIPDKINSLCSDCLK 1405

  Fly  2060 NATTCVVVLSDKTARLERGY----QLTRQICQACCGRLGS---LQCDSLDCPVLY 2107
            |  .|..:  .|.......|    .|...||:. |.:|.|   :.|.|..|.|.|
pombe  1406 N--PCATI--SKAVTQHNAYNKKLSLLFDICRG-CSKLSSSDPVLCKSNSCKVYY 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301	70/177 (40%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	66/223 (30%)
		POLBc_zeta	1550..2000	CDD:99917	209/453 (46%)
		zf-C4pol	2041..2107	CDD:405022	21/75 (28%)
rev3	NP_594068.1	PolB	483..1350	CDD:223494	339/1118 (30%)
		DNA_polB_zeta_exo	648..873	CDD:99821	68/231 (29%)
		POLBc_zeta	899..1344	CDD:99917	209/453 (46%)
		zf-C4pol	1399..1457	CDD:290959	20/62 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	395	1.000	Domainoid score	I112
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	661	1.000	Inparanoid score	I120
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	1	1.000	-	-		oto101418
orthoMCL	1	0.900	-	-		OOG6_102751
Panther	1	1.100	-	-	LDO	PTHR45812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R348
SonicParanoid	1	1.000	-	-		X3116
TreeFam	0	0.000	Not matched by this tool.
	11	10.890