DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and Nexmif

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001070822.2	Gene:	Nexmif / 245555	MGIID:	2148050	Length:	1515	Species:	Mus musculus

Alignment Length:	890	Identity:	177/890 - (19%)
Similarity:	299/890 - (33%)	Gaps:	270/890 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 ANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSNHTNPGIEAIWNDEKLRRQKLV 271
            ||....:.|.::.:.||.....|.......:||:.:.  ||::                   :|.
Mouse   686 ANGSHLRGLIVSDSVKVKAQDTEFKGPERKVLNKIKF--KSEA-------------------RLK 729

  Fly   272 EKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTALESKLMTLEQSTLSEQTLSDQTIL 336
            .|...||.|.|    ||:::.|                               :||.|.|...:.
Mouse   730 SKKIKAGQENK----PVVQMSP-------------------------------VSEDTSSKANLK 759

  Fly   337 PQATMQTTMPGT--KAQKRRFNLQKLLANAVYPEECSQDQQQLLVNASFIQNHVTCGYSSSVSLS 399
            .:.|     |||  .:....|:..|:..:...|..||.:......|.:.....:..||     |.
Mouse   760 NEVT-----PGTSNSSHMSEFHETKVKNSTFLPTTCSSEMPLSSANVATNIPVIPGGY-----LQ 814

  Fly   400 TSKDESDDLDETVVDEELILSLTQPHGAIPHDATLREEDLELLDALQLLEEQNESESHVDLDSSL 464
            |..|.||..:.|.:      |....|.|..::.:|.:.:...: .||..::...|.|.   ||.|
Mouse   815 TLLDASDLSNNTSI------SYFTNHSAEQNEGSLTQTEKAFV-PLQSAQDCVLSSSS---DSQL 869

  Fly   465 APLSQHKKFE------LTPELLDKETAATAALFDEDVDSDEDADQETRHDFSTVLDDVDELLLKL 523
            ...||:.|.|      |.|   ||:|:.:.. |..:|..:...:|.:..:.|.|: .::..|..:
Mouse   870 QQSSQNFKMEASNFGSLWP---DKDTSGSQE-FMTEVSREIATNQSSEFEASQVV-SMENNLTAI 929

  Fly   524 TQSQPAESKELKASSKLPQIDGADDRL--------------------QRTPIKSISSKSKSSPSK 568
            |.|....:.:....:|:......|..|                    |:.|:
Mouse   930 TYSPVCLNSDASGCNKVLYASLQDSHLPPEDLYQLCHFNNGEICFPFQQGPL------------- 981

  Fly   569 TPTTPIGQKSLPKSPRTPKTSAAKKYAPLAL-TIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGT 632
              :|....:.......|..|.::..|..|:| :.......:.||:|....| |:|.:|
Mouse   982 --STDDDGRLFSFDSMTSLTVSSSNYCSLSLKSCEKDGDDEINDDFLAHCS-PKLVIQ------- 1036

  Fly   633 GTLRPEISLRKKLAMSEMRRKSFEDSFVLLKNDCTPVRSTRRSTSNLDKTHIICSLTP-RDRNPG 696
                                :|.::           :...:.||..||    |.:.|| :.|:..
Mouse  1037 --------------------QSIDE-----------IAPLKESTDLLD----ISNFTPDKFRHSS 1066

  Fly   697 LSDMFETEDGKQLPPKKVVRKTRWSTRNQDI----------ESLPKAGCEIER-----PHRSEGS 746
            |.:| ...|...|.|:        |||.:.|          |.:|.:...:|:     ...|:.:
Mouse  1067 LLEM-SPPDTPSLSPQ--------STRCESIKTLGTMKGFQEGVPGSLSTVEKIKWDCNTLSQQA 1122

  Fly   747 ALDE---LKPRRSARHKVNSANPDECSSEIQTTGPRVTTTSLDRP----QKKARLSQSPKENTKT 804
            ..|:   |...:...|..|    ||.|..:....|.::|  .|.|    ...:::|:|.|   ||
Mouse  1123 QADDGFTLNSHQFQFHMFN----DEDSVGLLQKSPCLST--FDEPAGQINTNSKVSKSRK---KT 1178

  Fly   805 SMNGTVALEKATKDSSSNSESPHQQENSV----SEQIEYLESKPKKSDETARSCDEKLQRELIPQ 865
            |...:.|:.:::...:|..:||......|    |:....:....||....|....||:|   |..
Mouse  1179 SPGKSGAVSQSSSQKNSRKKSPKASNKGVEKPPSKTSRQVPKSTKKGKYVAAVNGEKMQ---IGI 1240

  Fly   866 EPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVTKLRKTPNLKRLR--WSIRSELLNKQFT 928
            ..:|..|..::::.:.:|....|...:.|           .|.|:.|.|.  |::..
Mouse  1241 GHSGGQPNSTSSNAKTLTECIQHGGPVAS-----------MKIPSQKGLSGDWALGK-------- 1286

  Fly   929 PSSGIRPPETETTPQLSPKSNESNTPELM----RSFYEHSLIVNSPSVFSDFLDSPEIHMDS--P 987
                      |:.|..:..|..:||..|:    |.|.|.|.|::  ::.|...|.....|.|  |
Mouse  1287 ----------ESRPGWNDMSVVTNTNNLLDDDQREFQEPSYILS--NIASGMADVQRFMMASMEP 1339

  Fly   988 RSAPP----------SPDSNSFVIAPLEL-----PPSYDEVVSGS 1017
            ...|.          ||||||..:..|::     ..|..:|.:||
Mouse  1340 LWEPMEHQGESNTFYSPDSNSLKLKTLKILAGTPQESKKKVTNGS 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821
		POLBc_zeta	1550..2000	CDD:99917
		zf-C4pol	2041..2107	CDD:405022
Nexmif	NP_001070822.2	DUF4683	284..690	CDD:374062	2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..415
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..529
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..774		16/82 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1225		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1372..1422		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1435..1479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930