DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DNApol-zeta and Rev3l

DIOPT Version :9

Sequence 1:NP_524881.2 Gene:DNApol-zeta / 47186 FlyBaseID:FBgn0002891 Length:2130 Species:Drosophila melanogaster
Sequence 2:XP_006512685.1 Gene:Rev3l / 19714 MGIID:1337131 Length:3123 Species:Mus musculus


Alignment Length:3190 Identity:891/3190 - (27%)
Similarity:1294/3190 - (40%) Gaps:1142/3190 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VYSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPY 75
            ::|||:|.||:||..|..|:|.|.|.|....:|:|||:||||....|||||:|:||:|||||:||
Mouse     1 MFSVRIVTADYYMASPLPGLDTCQSPLTQLPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPY 65

  Fly    76 DKKDFESLERGILQMAMHLDKAINISLGQGSSNAQHVFKIQLVKGIPFYGYHRVEHQFLKIYMFN 140
            |... :..|..:.|||..:|:|:|::||..||.||||||:.||.|:||||||..|..|:|||::|
Mouse    66 DGYG-QQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYN 129

  Fly   141 PRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFRR-------N 198
            |..|:|...|||||||::|.:.|||:|:||:||..||||||||:.::  |..:|||:       :
Mouse   130 PAMVKRICELLQSGAIMNKCYQPHEAHIPYLLQLFIDYNLYGMNLIN--LAAVKFRKARRKGNAS 192

  Fly   199 H---------------------DDDVIPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQ 242
            |                     ::|.||      :.|| :...:.::...||||..:..||||..
Mouse   193 HATGLFKHQLSGNSPAGTLFRWEEDEIP------SSLL-LEGVEPLSTCELEVDAVAADILNRLD 250

  Fly   243 LVAKSKSNHTNPGIEAIWNDEKLRRQKLVE-KHTDAGDEEKAEAVPVLELPPT-QERHQIEIAES 305
            :.|:...   |||::|||.|||.||:...| ......:.:....||..|.... |:|.|..:.::
Mouse   251 IEAQIGG---NPGLQAIWEDEKQRRRNRNESSQISQPESQDCRFVPATESEKQFQKRLQEVLKQN 312

  Fly   306 DIFYRT------------------ALESKLMT----------------------------LEQST 324
            |...||                  .|.|::::                            :|::.
Mouse   313 DFSVRTLSGSVDYSNGSQEFSAELTLHSEILSPEMLPCSPANMIEVHKDTDLSKGNTKHKVEEAL 377

  Fly   325 LSEQTL-----SDQTILPQATMQTTMP---------------------GTKAQKRRFNLQ-KLLA 362
            ::|:.:     :.||..|.....:..|                     |.:.:|.|..|. ....
Mouse   378 INEEAILNLIENSQTFQPLTQRLSETPVFMGSSPDESLVHLLAGLESDGYQGEKNRMPLPCHSFG 442

  Fly   363 NAVYPEECSQDQQQLLVNA--------------SFIQNHVTCGYSSSV-----SLSTSKDESDDL 408
            .:..|:....::.:..:..              |.|:.|  |....|:     ..||.:|:|...
Mouse   443 ESQNPQNSDDEENEPQIEKEEMELSVVMSQRWDSDIEEH--CAKKRSLCRNAHRSSTEEDDSSSE 505

  Fly   409 DETV-VDEELI---LSLTQPHGAI--------------PHDATLREEDLEL------LDALQL-- 447
            :|.. .|..|:   ||:.|..|..              .|.:.:....|.:      .||..|  
Mouse   506 EEMEWTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSIFHKDAATLEP 570

  Fly   448 -----------------------------LEEQNESESHVD------------------LDSSLA 465
                                         |.:.|.:|...|                  |.|::.
Mouse   571 PSSAKITFQCKHTSALSSHVLNKDGLTEDLSQPNSTEKGRDNSVTFTKESTYSMKYSGSLSSTVH 635

  Fly   466 PLSQHKKFELTPELLDKE-----TAATAALFD--EDVDS----------------DEDAD--QET 505
            ..:.||      |:..|:     ::..:::||  ||:.|                ::||.  ...
Mouse   636 SDNSHK------EICKKDKSLPVSSCESSVFDYEEDIPSVTRQVPSRKYSNMRKIEKDASCIHVN 694

  Fly   506 RHDFSTVLD-------DVDELLLKLTQSQPAESKELKASSKLPQI---------DGADDRLQRTP 554
            ||...|:|.       |::....||:.....:......|...|..         ...::|.....
Mouse   695 RHISETILGKNSFNFADLNHSKRKLSSEGNEKGNSTSLSGVFPSSLTENCDLLPSSGENRSMAHS 759

  Fly   555 IKSISSKSKSSPSKTPTTPIGQKSLPK----------------------------SPRTPKTSAA 591
            ::||:.:|..:..|.......:..:.|                            ||.|.|..:.
Mouse   760 LESITDESGLNKLKIRYEEFQEHKMEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQSG 824

  Fly   592 KKYAPLALT---------------------------------------IGSSSSKKSNDEFAGRP 617
            .|.:.|.|.                                       :.|.|:|.::..|..:|
Mouse   825 NKPSRLKLNKKKLIGLQETSTKSTETGATKDSCTHNDLYTGASEKENGLSSDSAKATHGTFENKP 889

  Fly   618 SNPRLSLQLDQGTGTGTLRPEISL---RKKLAMSEMRRKSFE----DSFVLLKNDCTPVRSTRRS 675
            .....   :|...|.|:|..|.|.   ..|..:...|:.::|    :|..:.:|....:......
Mouse   890 PTEHF---IDCHFGDGSLEAEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTQNSKISLPHPMEI 951

  Fly   676 TSNLDKT-------------------HIICSLTPRDRNP----GLSDMFE-----TEDGKQLPPK 712
            ..|||.|                   :||.:.....:|.    |..|..|     ||:..:|..|
Mouse   952 GENLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKK 1016

  Fly   713 KVVRKTRW-------STRNQDIESLPKAGCEIERPHRSEGSALDELKPRRSARHKVNSAN----- 765
            ....|..|       :|:.......||.....:..|:|       .|.:...:|:.||.|     
Mouse  1017 LAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKS-------AKKKPGKQHRTNSENIKRTL 1074

  Fly   766 --------------------------------------------------PDEC-------SSEI 773
                                                              |..|       :.||
Mouse  1075 SFRKKRTHAVLSPPSPSYIAETEDCDLSYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEI 1139

  Fly   774 -------------------QTTGPRV--------------------------------TTTSLDR 787
                               :|..|||                                ||..:|.
Mouse  1140 MAAAEKESMLFKGPNVYNTKTVSPRVGKASRARAQVKKSKARLANSSVVTNKRNKRNQTTKLVDD 1204

  Fly   788 PQKKARLSQSPKENTK--------------------------------TSMNGTVALEKATKDSS 820
            .:||.|..|..:.|.|                                ||.:|..||.|..:.|.
Mouse  1205 GKKKPRAKQKQRANEKSLSRKHAIPADEKMKPHSEAELTPNHQSVSELTSSSGAQALSKQKEMSQ 1269

  Fly   821 SNSESPH----QQENSVSEQ-------IEYLESK------------------------------- 843
            :.....|    .|...:|.|       ..:||||                               
Mouse  1270 TGPAVDHPLPPAQPTGISAQQRLSNCFSSFLESKKSVDLRTFPSSRDDSHSSVVYSSIGPGISKI 1334

  Fly   844 ----------------------------------------------PK--KSDETARSCDEKL-- 858
                                                          ||  :|..|.::|...:  
Mouse  1335 NIQRSHNQSAMFTRKETTLIQKSIFDLSNHLSQVAQSTQVCSGIISPKTEESSSTQKNCGSSMGK 1399

  Fly   859 ---QRELIPQEPAGI-SPG-----DSANSTEEI--------TFSPCHDEAIESDTESDYIVTKLR 906
               .|..:..:|..: :|.     ||...|..:        |.||.:..:.||.|.:.: ||.| 
Mouse  1400 LNEYRSSLESKPEQVCAPNFLHCKDSQQQTVSVSEQSKTSETCSPGNAASEESQTPNCF-VTSL- 1462

  Fly   907 KTPNLKRLRW------------------------------------------------------- 916
            |:| :|::.|                                                       
Mouse  1463 KSP-IKQIAWEQKQRGFILDMSNFKPEKVKQRSLSEAISQTKALSQCKNQNVSTPSVFGEGQSGL 1526

  Fly   917 SIRSELL-----------------------------------NKQFTPSSGIRPPET-------E 939
            ::..|||                                   ||:..|.:..|.|.|       |
Mouse  1527 AVLKELLQKRQQKAQSTNVVQDSTSTHQPDKNISVSNEHKKANKRTRPVTSPRKPRTPRRTKPKE 1591

  Fly   940 TTPQ-----------------------------------------LSPKSN---ESNT------- 953
            .||:                                         |||:.|   :.||       
Mouse  1592 QTPRRLKVDPLNLQTSGHLDNSLSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFC 1656

  Fly   954 ----------------------------------------------------------------- 953
                                                                             
Mouse  1657 SFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIDKSELLSHDRQSCSEEKHHVSDSSPWIRASTL 1721

  Fly   954 -PELM-----------------RSFYEHSLIVNSPSVFSDFL------------------DSPEI 982
             |||.                 .||  |.|..:|.|:...|.                  .|.|:
Mouse  1722 NPELFEKVAMDNNENHRHSQWKNSF--HPLTSHSNSIMESFCVQQAENCLTEKSRLNRSSVSKEV 1784

  Fly   983 HMDSPR------------------------------SAP------------------------PS 993
            .:..|:                              |:|                        |:
Mouse  1785 FLSLPQANSSDWIQGHNRKEADQSLHSANTSFTTILSSPDGELVDAASEDLELYVSRNNDVLTPT 1849

  Fly   994 PDSN-------------SF------VIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDV- 1038
            |||:             ||      ::.||..|||.:|:|:.....|:.|..:|:|:.|||||| 
Mouse  1850 PDSSPRSTSSPLQSKNGSFTPRTAHILKPLMSPPSREEIVATLLDHDLSEAIYQEPFCSNPSDVP 1914

  Fly  1039 SKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHR-------GEQ 1096
            .|..|:|..:|.:.....||...|:.....: ||..|:      ....||.|..|       |:.
Mouse  1915 EKPREIGGRLLMVETRLPNDLIEFEGDFSLE-GLRLWK------TAFSAMTQNPRPGSPLRNGQA 1972

  Fly  1097 KVREYFST------QQRIAIEPAQLAPTWQEAKIWLKAK-ELLRQREEPK-------KSSDDIDS 1147
            .|.:..|.      .::|.|.|.:.||:.|..:.||:|| |..|.::.||       ||::::..
Mouse  1973 VVNKESSNSHKMVEDKKIVIMPCKYAPSRQLVQAWLQAKEEYERSKKLPKTELTPVTKSAENVSP 2037

  Fly  1148 PI---------------------------KIKRQKITMML------------------QAEEGDG 1167
            .:                           ::.:.:|.:..                  :.:|.|.
Mouse  2038 SLNPGDTCAVSPQVDKCPHTLSSSAHTKEEVSKSQIALQTSTTGCSQTLLAAASAAVPEEDEDDN 2102

  Fly  1168 G----------------------------SGDE---DAGEELDCSLS----LTPLSQA--KDKCK 1195
            .                            :||:   ..|:|| |||:    |.|:...  |..|.
Mouse  2103 DNCYVSYSSPDSPGIPPWQQAASPDFRSLNGDDRHSSPGKEL-CSLAVENFLKPIKDGIQKSSCS 2166

  Fly  1196 -------ATPTSSKARETGK-----------------SRLKRGTRLSFIGSQDEEPPSSQSSEQS 1236
                   .:|..::|| |||                 .:|...|.||.:..:    |.:|.....
Mouse  2167 ESWEPQVISPIHARAR-TGKWDPLCLHSTPVMQRKFLEKLPEATGLSPLSVE----PKTQKLYNK 2226

  Fly  1237 VSSSA---------AQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAK 1292
            ..|.|         .|.|...::.....:.:||         :...:|:||:||||:::|||:||
Mouse  2227 KGSDADGLRRVLLTTQVENQFAAVNTPKKETSQ---------IDGPSLNNTYGFKVSIQNLQEAK 2282

  Fly  1293 ADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAI--EHSLPD-EKLPSKACGYIMVN--- 1351
            |..:..:||:|::|:...||.||||||..|.|..|||.|  :..||| ||  ::..|.|:::   
Mouse  2283 ALHEIQNLTLISVELHARTRRDLQPDPEFDPICALFYCISSDTPLPDTEK--TELTGVIVIDKDK 2345

  Fly  1352 --TVQDLLSEGPF---HGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVID 1411
              |.||:.|:.|.   .|| ..:||.....|...|:.:..:.:|:|.||..||||:|.||||::.
Mouse  2346 TVTHQDIRSQTPLLIRSGI-TGLEVTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQ 2409

  Fly  1412 RAKHLCFNIAPLLSRVPTQKVRDFVDEDREQF-TDLDVEMKLCGRILLDVWRLMRSEIALTSYTF 1475
            ||..|..::..::||||..|:.:....:|:.: :|...|:.:.|||.|::||:||:|:|||:|||
Mouse  2410 RAAALSVDLCQMISRVPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTF 2474

  Fly  1476 ENVMYHILHKRCPWHTAKSLTEWFGSPCT--RWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKL 1538
            |||.:|:||:|.|..|.:.|::||.:...  ||.::::|:.||||.|.:|:||||:|:|||||:|
Mouse  2475 ENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARL 2539

  Fly  1539 IGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLI 1603
            .||||..||:||||:||||||||||||.|.:|::||:|.|:.||||:.:.|||||:||||::.::
Mouse  2540 FGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVPLIMEPESRFYSNSVL 2604

  Fly  1604 VLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGV 1668
            ||||||||||::||||||||||||.||:||....|:||.:.|||...:|.: :.|| |||||.||
Mouse  2605 VLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQ-IRHD-VTVSPNGV 2667

  Fly  1669 VFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANF 1733
            .|||..||:|:|||||.|||.||.|||||||.:|...||.|:|::|||||||:||||:|||||||
Mouse  2668 AFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANVTFGYTAANF 2732

  Fly  1734 SGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEI 1798
            |||||.:|||||:|.|.|||||||||||.:.::|..|||||||||||||:.|..:.::|:||:||
Mouse  2733 SGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEI 2797

  Fly  1799 AKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKM 1863
            |:|||..||:|||||.||||.||:||||||||||||||.||::||::||||||||||.||||:|:
Mouse  2798 AEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVFDAKGIETVRRDSCPAVSKI 2862

  Fly  1864 LEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVPALELTRKW 1928
            ||:.|::||||:|:|.||.||.||..||:.|:|::||.|||||:||...|:|.|||||||||||.
Mouse  2863 LERSLKLLFETRDISLIKQYVQRQCMKLVEGKASIQDFIFAKEYRGSFSYRPGACVPALELTRKM 2927

  Fly  1929 MQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNRCLL 1993
            :..|.|..||.|||||::|:.|.||:.||:|:|.|.::|.:...::||.|||||.|:|||.|...
Mouse  2928 LAYDRRSEPRVGERVPYVIIYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFS 2992

  Fly  1994 LIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCL 2058
            |||.:|..|:..|||  :......:.:||.|.:|   ||||||:|..|.: |...|:.|||..|.
Mouse  2993 LIGIDVFSWYQELPR--IQKATSSSRSELEGRKG---TISQYFTTLHCPV-CDDLTQHGICSKCR 3051

  Fly  2059 KNATTCVVVLSDKTARLERGYQLTRQICQACCGRLG-SLQCDSLDCPVLYVLEGKRRELQQIEHW 2122
            .......::|:.:...|||..:...:||:.|.|... .:.|.||:||||:.|....|||.:..:.
Mouse  3052 SQPQHVAIILNQEIRELERKQEQLIKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNRELSKAPYL 3116

  Fly  2123 NKLLE 2127
            .:||:
Mouse  3117 RQLLD 3121

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-zetaNP_524881.2 PTZ00166 20..>196 CDD:240301 94/175 (54%)
DNA_polB_zeta_exo 1297..1518 CDD:99821 92/234 (39%)
POLBc_zeta 1550..2000 CDD:99917 290/449 (65%)
zf-C4pol 2041..2107 CDD:405022 21/66 (32%)
Rev3lXP_006512685.1 PTZ00166 6..>195 CDD:240301 99/191 (52%)
DUF4683 747..1133 CDD:374062 57/395 (14%)
DNA_polB_zeta_exo 2287..2525 CDD:99821 95/240 (40%)
POLBc_zeta 2551..2999 CDD:99917 290/449 (65%)
zf-C4pol 3035..3102 CDD:372984 22/67 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 589 1.000 Domainoid score I204
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1190 1.000 Inparanoid score I192
Isobase 1 0.950 - 0 Normalized mean entropy S3397
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D20210at2759
OrthoFinder 1 1.000 - - FOG0001033
OrthoInspector 1 1.000 - - oto93882
orthoMCL 1 0.900 - - OOG6_102751
Panther 1 1.100 - - LDO PTHR45812
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R348
SonicParanoid 1 1.000 - - X3116
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.810

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