DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and Pole

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_035262.2	Gene:	Pole / 18973	MGIID:	1196391	Length:	2283	Species:	Mus musculus

Alignment Length:	1680	Identity:	307/1680 - (18%)
Similarity:	504/1680 - (30%)	Gaps:	661/1680 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   691 RDRNPGLSDMFETEDG--KQLPPKKVVRKTRWSTRNQDI----ESLPKAGCEIERP------HRS 743
            |...||.......:||  ..:...|.:.:::| |...|:    |.|.:.|   ||.      |.:
Mouse     9 RHPEPGADGEGSRDDGPSSSVSALKRLERSQW-TDKMDLRFGFERLKEPG---ERTGWLINMHPT 69

  Fly   744 EGSALDELKPRRSA-----------RHKVNSANP----------DECSSEIQTTGPRVTTTSLDR 787
            |  .|||.|...||           |.||  |.|          ..|..|:.      :..|...
Mouse    70 E--ILDEDKRLVSAVDYYFIQDDGSRFKV--ALPYMPYFYIAARKGCDREVS------SFLSKKF 124

  Fly   788 PQKKARLSQSPKEN--------------TKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIE 838
            ..|.|:|...|||:              .|.|.:....|.|..|:.|...:...:|:::..|...
Mouse   125 QGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTT 189

  Fly   839 YLESKPK------KSDETARSCDEKL-----QREL-IPQE------------------------P 867
            .|.|..:      ..|||::...::|     .||. :|..                        |
Mouse   190 MLSSILQGGSVITDEDETSKKIADQLDNIVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRGNAFP 254

  Fly   868 AGISPGDSANSTEE---ITFSPCHDEAIES--------DTESD-------------YIVTKLRKT 908
            ..|:..|......:   :.|.      ||:        |.|:|             |::|.
Mouse   255 VEITRRDDLVERPDPVVLAFD------IETTKLPLKFPDAETDQIMMISYMIDGQGYLITN---- 309

  Fly   909 PNLKRLRWSIRSELLNKQFTPSSGIRPPETETTPQLSP--KSNESNTPELMRSFYEHSLIVNSPS 971
                  |..:..::.:.:|||.     ||.|     .|  ..||.:...|::.::|| :....|:
Mouse   310 ------REIVSEDIEDFEFTPK-----PEYE-----GPFCVFNEPDEVHLIQRWFEH-IQETKPT 357

  Fly   972 VF----SDFLDSPE-------------------------------IHMDSPR-----SAPPSPDS 996
            :.    .||.|.|.                               ||||..|     |..|....
Mouse   358 IMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSH 422

  Fly   997 NSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVSKV-TEVGFLVLHIPGNKLNDCD 1060
            |....|..:|  .||                  |...:|.|:.:: ||
Mouse   423 NLKAAAKAKL--GYD------------------PVELDPEDMCRMATE----------------- 450

  Fly  1061 PFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEPAQL----APTWQE 1121
                   ..:.||::.....:|...|.|...|      ...|:....|.:||.::    :.|..|
Mouse   451 -------QPQTLATYSVSDAVATYYLYMKYVH------PFIFALCTIIPMEPDEVLRKGSGTLCE 502

  Fly  1122 AKIWLKA--KELL---RQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSGDE-DAG---EE 1177
            |.:.::|  ..::   :|.:|..|.:||            ..||.||...||..:. ::|   .:
Mouse   503 ALLMVQAFHANIIFPNKQEQEFNKLTDD------------GHMLDAETYVGGHVEALESGVFRSD 555

  Fly  1178 LDCSLSLTP-----LSQAKDKCKATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSSE-QS 1236
            :.|...:.|     |.|..:|     |...|.|                 ::|:.|..|::. |.
Mouse   556 IPCRFRMNPAAFDFLLQRVEK-----TMRHAIE-----------------EEEKVPVEQATNFQE 598

  Fly  1237 VSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDC---N 1298
            |...                                        .|..|.:|:.....|:|   .
Mouse   599 VCEQ----------------------------------------IKTKLTSLKDVPNRIECPLIY 623

  Fly  1299 HLTIITLEVFVSTRGDLQPDPMHDEIRCL------------------------------FYAIEH 1333
            ||.:..:...:.....|||..:.||..|.                              ::.|:|
Mouse   624 HLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGASCQRKMAWQWRGEFMPASRSEYHRIQH 688

  Fly  1334 SLPDEKLPSKACGYIMVNTVQDLLSEGP---FHGIDRDIEV----------------QVVTSEAE 1379
            .|..||.|             .|..|||   ||.:.|:.:.                ::..::.|
Mouse   689 QLESEKFP-------------PLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHVTKVE 740

  Fly  1380 AFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQFT 1444
              |.|..:|:|.::              :.:|                   .||.|.|. |.:|.
Mouse   741 --ERLTTICQRENS--------------FYVD-------------------TVRAFRDR-RYEFK 769

  Fly  1445 DLD----------------VEMKLCG--RILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHT 1491
            .|.                .|:|.|.  .||.|..:|....|..:.|.:      ::.|...|::
Mouse   770 GLHKVWKKKLSAAVEVGDASEVKRCKNMEILYDSLQLAHKCILNSFYGY------VMRKGARWYS 828

  Fly  1492 -----------------AKSLTEWFGSPCTR-----WIVM-----EYYLERVRGTLTLLDQLDLL 1529
                             |:.|.|..|.|...     |.|:     |.::  ::.|.....:|.:
Mouse   829 MEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFV--IKTTNAKKPKLTI- 890

  Fly  1530 GRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQ 1594
               |....::.|...|..: ..|::      .:.:|.:|..::.|..:........|||:|: |.
Mouse   891 ---SYPGAMLNIMVKEGFT-NHQYQ------ELTEPSSLTYVTHSENSIFFEVDGPYLAMIL-PA 944

  Fly  1595 SRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHD 1659
            |:.....|              ...|......|.:..|.|   ||            :::..|..
Mouse   945 SKEEGKKL--------------KKRYAVFNEDGSLAELKG---FE------------VKRRGELQ 980

  Fly  1660 LVTVSPCGV--VFVKREVRE---GILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLK 1719
            |:.:....|  .|:|....|   |.:.::....||.......:|   .||...:.|..:|.:..|
Mouse   981 LIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANM---PDSELFELISENRSMSRK 1042

  Fly  1720 L-------MANVTYGYTAANFSGRMPSVEVGDS---VVSK---GRETLERAIKLV---------- 1761
            |       ..:::.....|.|.|.....:.|.|   ::|:   |....||||.|.
Mouse  1043 LEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRK 1107

  Fly  1762 ---------ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVT-------EMNPQP- 1809
                     .:.:::.:|.:. |.|....           |:|..|.|.:|       ..||.|
Mouse  1108 HFLRKWLKSSSLQDFDIRTIL-DWDYYIE-----------RLGSAIQKIITIPAALQQVKNPVPR 1160

  Fly  1810 VK---------------LKLEKVYQPCMLQTKKRYVGYMYETADQE----QPVYEAKGIETVRRD 1855
            ||               .|.:|:.:..:|:.|::.|  |.:.::..    .|..|..|:......
Mouse  1161 VKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIV--MAQASENSLSLCTPDMEDIGLTKPHHS 1223

  Fly  1856 GCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVP 1920
            ..|...|.     :.::|||..|                    ||:.....::.:.|..|:....
Mouse  1224 TVPVATKR-----KRVWETQKES--------------------QDIALTVPWQEVLGQPPSLGTT 1263

  Fly  1921 ALEL-------TRKW-MQKDPRHVPRRGER------VPFI--IVNGPP---GMQLIRLVRSPHDI 1966
            ..|.       .:|| :|...|...|:.:|      :|.:  |..||.   |..|.|..||..|:
Mouse  1264 QEEWLVWLQFHKKKWQLQAQQRLALRKKQRLESAEDMPRLGPIREGPSTGLGSFLRRTARSIMDL 1328

  Fly  1967 LANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANE 2021
            ...       |..|::.....|.|...:||.::|....|:||...:...|..|.:
Mouse  1329 PWQ-------IIQISETRQAGLFRLWAIIGNDLHCIKLSIPRVFYVNQRVAKAED 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	54/317 (17%)
		POLBc_zeta	1550..2000	CDD:99917	100/532 (19%)
		zf-C4pol	2041..2107	CDD:405022
Pole	NP_035262.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		5/22 (23%)
		PolB	99..1165	CDD:223494	233/1335 (17%)
		Lyase_I_like	<125..>231	CDD:294018	23/105 (22%)
		DNA_polB_epsilon_exo	268..471	CDD:99822	47/273 (17%)
		POLBc_epsilon	531..1153	CDD:99918	136/796 (17%)
		DUF1744	1528..1924	CDD:285663
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1935..1968
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2014..2041
		CysB motif. /evidence=ECO:0000250\|UniProtKB:P15436	2218..2235
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900