Protein Alignment DNApol-zeta and Pold1

DIOPT Version :9

• Sequence 1: NP_524881.2
• Gene: DNApol-zeta / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_035261.3
• Gene: Pold1 / 18971
• MGIID: 97741
• Length: 1105
• Species: Mus musculus
• Alignment Length: 1169
• Identity: 288/1169 - (24%)
• Similarity: 476/1169 - (40%)
• Gaps: 237/1169 - (20%)

  Fly  1086 LAMLQRHRGEQKVREYFSTQQRIAIEP----------AQLAPTWQEAKIWLKA-----KELLRQR 1135
            ||:|:....|.:::|   .::.:.:.|          |.:.|.|:...  |:|     :.|:.|:
Mouse    37 LALLEEIEAENRLQE---AEEELQLPPEGTVGGQFSTADIDPRWRRPT--LRALDPSTEPLIFQQ 96

  Fly  1136 EE----------------PKKSSDDIDSPIKIKRQKITMM------------------------- 1159
            .|                |.::|..|.....:..:..::.
Mouse    97 LEIDHYVGSAPPLPEGPLPSRNSVPILRAFGVTDEGFSVCCHIQGFAPYFYTPAPPGFGAEHLSE 161

  Fly  1160 LQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKC-----------------KATPTSSKARETG 1207
            ||.|.....|.|:..|:||.     .|...|.:.|                 :.|....:.....
Mouse   162 LQQELNAAISRDQRGGKELS-----GPAVLAIELCSRESMFGYHGHGPSPFLRITLALPRLMAPA 221

  Fly  1208 KSRLKRGTRLSFIGSQDEEPPSSQSSEQSVS-----------SSAAQAELDRSSFLRQLEGSSQD 1261
            :..|::|.|:..:|:     ||....|.:|.           ......||....::|:.|..:..
Mouse   222 RRLLEQGVRVPGLGT-----PSFAPYEANVDFEIRFMVDADIVGCNWLELPAGKYVRRAEKKATL 281

  Fly  1262 RQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDE-IR 1325
            .|.::....|........|....:..|:....||:|            :.|..:.|:|..|. |:
Mouse   282 CQLEVDVLWSDVISHPPEGQWQRIAPLRVLSFDIEC------------AGRKGIFPEPERDPVIQ 334

  Fly  1326 CLFYAIEHSLPDE----KLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQVVTSEAEAFEALLA 1386
            .....:....|:.    .|..:.|..|:                  ..:||....|.:..:|...
Mouse   335 ICSLGLRWGEPEPFLRLALTLRPCAPIL------------------GAKVQSYEREEDLLQAWAD 381

  Fly  1387 LCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVP--TQKVRDFVDEDREQFTDLDVE 1449
            .....|.|:..||.|:.....|:|.||:.|..:..|.|.||.  ...:||...:.|:........
Mouse   382 FILAMDPDVITGYNIQNFDLPYLISRAQALKVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRDSKV 446

  Fly  1450 MKLCGRILLDVWRLMRSEIALTSYTFENVMYHIL--HKRCPWHTAKSLTE-WFGSPCTRWIVMEY 1511
            :.:.||:.:|:.:::..|..|.|||...|.:|.|  .|....|:.  :|: ..|:..||..:..|
Mouse   447 ISMVGRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQHSI--ITDLQNGNEQTRRRLAVY 509

  Fly  1512 YLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQ 1576
            .|:.....|.||::|.:|....|||::.|:....:|:||.|.:|.|.:||.|..:.|  |.|.|:
Mouse   510 CLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLTRGQQVKVVSQLLRQAMRQGL--LMPVVK 572

  Fly  1577 ARAHMRAPEYL-ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCL--GRVEHLGGSSPF 1638
            ...   :.:|. |.::||...:|..|:..|||.|||||:::|:|.|::|.|  |..:.||
Mouse   573 TEG---SEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQKLG----- 629

  Fly  1639 EFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKD 1703
                             |:.|....:|.|..|||..||:|:||::|..:|..|:..|  .:|.::
Mouse   630 -----------------LKPDEFIKTPTGDEFVKSSVRKGLLPQILENLLSARKRAK--AELAQE 675

  Fly  1704 SSALQR-ILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKL------V 1761
            :..|:| :|..|||.||:.||..||:|.|.. |::|.:|:..||...||:.:|:..:|      |
Mouse   676 TDPLRRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTV 739

  Fly  1762 ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTK 1826
            ||..:...:||||||||:.......:.|||..:|.|.|..|:...|.|::|:.||||.|.:|.:|
Mouse   740 ENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYLLISK 804

  Fly  1827 KRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKL 1891
            |||.|.::.:........:.||:|.||||.||.||.::...||.:...:|.....|:.....:.|
Mouse   805 KRYAGLLFSSRSDAHDKMDCKGLEAVRRDNCPLVANLVTSSLRRILVDRDPDGAVAHAKDVISDL 869

  Fly  1892 LSGRANLQDLIFAKE-------FRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVN 1949
            |..|.::..|:..||       :.|...:        :||..:..::||...|..|:|||::|:.
Mouse   870 LCNRIDISQLVITKELTRAAADYAGKQAH--------VELAERMRKRDPGSAPSLGDRVPYVIIG 926

  Fly  1950 GPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNR------------CLLLIGANVHDW 2002
            ...|:........|..:| .....|:..||:.:.:..||.|            .:||.|.:..
Mouse   927 AAKGVAAYMKSEDPLFVL-EHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAESVLLRGDHTR-- 988

  Fly  2003 FASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGR--QTKAGICPDCL-KNATTC 2064
                 .|.::|..||             .:..:....:|.|.|..  ..:..:|..|. :.:...
Mouse   989 -----CKTVLTSKVG-------------GLLAFTKRRNCCIGCRSVIDHQGAVCKFCQPRESELY 1035

  Fly  2065 VVVLSDKTARLERGYQLTRQICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIEHWNKLLE 2127
            ...:|...|..||..:|..| ||.|.|.| ..:.|.|.|||:.|:.:..|::|:..|   :||:
Mouse  1036 QKEVSHLNALEERFSRLWTQ-CQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQE---RLLQ 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	50/230 (22%)
		POLBc_zeta	1550..2000	CDD:99917	149/478 (31%)
		zf-C4pol	2041..2107	CDD:405022	21/69 (30%)
Pold1	NP_035261.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Nuclear localization signal. /evidence=ECO:0000255	4..19
		PTZ00166	78..1098	CDD:240301	279/1125 (25%)
		CysB motif	1056..1074		7/17 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810