Protein Alignment PolZ1 and pola-1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_001255109.1
• Gene: pola-1 / 176544
• WormBaseID: WBGene00012936
• Length: 1428
• Species: Caenorhabditis elegans
• Alignment Length: 1572
• Identity: 305/1572 - (19%)
• Similarity: 550/1572 - (34%)
• Gaps: 474/1572 - (30%)

  Fly   735 CEIERPHRSEGSALDELKPRRSARHKVNSANPDECSSEIQTTGPRVTTTSLDRPQKKARLSQSPK 799
            |.:.:....|.||:::||..||..   .:..|:....::..|        :|..:.:..:::..|
 Worm    19 CGVSQKKSKELSAIEQLKLARSTG---KAYRPELDVEDVYDT--------VDDDEYEKIVAKRQK 72

  Fly   800 ENTKTSMNGTVALEKAT--KDSSSNSESPHQQENSVSEQIEYLESKPKKSDETARSCDEKLQREL 862
            :|.....:|...::...  :|...:..:|...:||.|.:..  |.||||        |:|
 Worm    73 DNFIVDDDGMGYVDNGVDFEDDYEDDYAPSSSKNSNSSKKG--EKKPKK--------DKK----- 122

  Fly   863 IPQEPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVTKLRKTPNLKRLRWSIRSELLNKQF 927
                ..|:....|..||::    |..:..::::.:.|..|..:     |::|
 Worm   123 ----KGGLHAFLSTTSTKK----PIDESVVKAEFDDDEEVKNM-----LEQL------------- 161

  Fly   928 TPSSGIRPPETETTPQLSPKSNESNTPELMRSFYEHSLIVNSPSVFSDFLDSPEIHMDSPRSAPP 992
                |....|.|..|:.:|    :|..:..|.|                        |||
 Worm   162 ----GSSDEEAEEKPKATP----ANPFKRGRKF------------------------DSP----- 189

  Fly   993 SPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVSKVTEVGFLVLHIPGNKLN 1057
               |.|..:||..:........:|     :.|::||:                    |:   |::
 Worm   190 ---SGSDSLAPRPIAKKAKREATG-----LAEHKFQR--------------------HV---KVD 223

  Fly  1058 DCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEPAQLAPTWQEA 1122
            :.:.:.  :.:|..:||                      .|.....|::...:| |..||..|
 Worm   224 EDEDYG--IPDDYPVAS----------------------PVTSPVKTEKMAEVE-APTAPAIQ-- 261

  Fly  1123 KIWLKAKELLRQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSG---DEDAGEELDC---- 1180
                |.:|.::...|..:..:|..:..::          .|:..|||.   |||...|:..
 Worm   262 ----KIEETVKMETEHLEEVEDSLAKFRV----------IEDWTGGSSSQEDEDVKVEVKTGSEA 312

  Fly  1181 ------------SLSLTPLSQAKDKCKA---------TPTSSKARETGKSRLKRGTRLSFIGSQD 1224
                        ::.:..:...:|..||         ..||..|.||....:|...|..:.
 Worm   313 FYTMGGEDNTTKAIRMYWIDAYEDVHKANGTVYLFGKVKTSGNAWETCSIVVKNICRKVYF---- 373

  Fly  1225 EEPPSSQSSEQSVSSSAAQAELDRSSFLR--------QLEGSSQDRQHDLSFG------------ 1269
              .|.:::......||.|:...:....||        :.:...::...|.|||
 Worm   374 --MPRTKNLSTGEESSLAELHKEIGDVLRNKFNTHEFKCKMVEKELIRDESFGYGCGTKSPLMEV 436

  Fly  1270 ------------LSHATLDNTFG---------------------------------------FKV 1283
                        |...|..|||.                                       |:|
 Worm   437 LYPAEKGKLPSDLKGDTFSNTFNTSVTPLERLLIEKKFMGPGWIELYNYSDPKAKTSNCKYEFEV 501

  Fly  1284 NLENLQQAK----ADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYA---IEHSLPDEKLP 1341
            ::|.::..|    :|.....:.::.|.| |:|..| :.|.....|..||..   :.|...|.|..
 Worm   502 DMEKMRNIKYLESSDAPPPTIKLLALNV-VTTLND-RKDNEICMISMLFNPKCDLAHPSGDSKDL 564

  Fly  1342 SKACGYIMVNTVQDLLSEGPFHGIDRDIE-----------VQVVTSEAEAFEALLALCERWDADI 1395
            ...|          |:::.|...:..||:           |:.|.:|.......||:....:.|:
 Worm   565 KPKC----------LVTKPPGGSLPYDIQKRLETEKLSKFVKSVANEKALLTLFLAMINEDEPDM 619

  Fly  1396 YAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQFTDLDVEMKL-------- 1452
            ..|:::..:               ||.|:||:...|:.::     .:.:.|...:.:
 Worm   620 IVGHDLSAT---------------IALLVSRLEKLKLPNW-----SRISRLKRSINIGKIGHSKS 664

  Fly  1453 ------CGRILLD----VWRLMRSEIALTSYTFENVMYHILHKRCPWHTAKSLTEWFGSPCTRWI 1507
                  .||::||    ...|::|.    |:....:...||........|..:.:.:........
 Worm   665 GQWELTAGRMMLDSKLAAMELVKSR----SFDLTELSQQILGAERREIYANEIPQLYVDSKDLIS 725

  Fly  1508 VMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLS 1572
            ::.:....:..:|.::.:|:.|....::::::|......:..|...|.|.::|...:..:|:...
 Worm   726 LINWSWNDLLLSLRIVVRLNALPLYIQISQIVGGIASRTMMGGRAERNEYLLLHAFEKADLIAPD 790

  Fly  1573 PSVQARAHMRAPEYL--------------ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFS 1623
            ....:.:..:..|..              .|::||:...|...:::|||.|||||:|..||.|::
 Worm   791 KYNSSESKKKKEESQEGDEKKSGKAQYSGGLVLEPKKGLYETLILLLDFNSLYPSIIQEYNICYT 855

  Fly  1624 TCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEIL 1688
            |    :|:...|.      .||.|.:..       |:                ||:|||.:.:::
 Worm   856 T----LEYSKDSD------EQLSVPQST-------DI----------------EGVLPREIRKLV 887

  Fly  1689 DTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRET 1753
            :.|:.||..||..: :.|.::.:..||:.|||.||..||.....:| |..:..:...|.:||||.
 Worm   888 ECRRDVKSLMKSER-NEAKKKQMDIRQMALKLTANSMYGCLGFQYS-RFYAKPLAALVTAKGREI 950

  Fly  1754 LERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVY 1818
            |..:..||   |:....||||||||:.:.....:...|.::|.||.|||.:.: :.::|.|:.|:
 Worm   951 LMHSKDLV---EKMGYSVVYGDTDSIMINTNSVDLVAAKKLGNEIKKAVNKCH-RLLELDLDGVF 1011

  Fly  1819 QPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRD--------GCPAVAKMLEKVLRILFETQ 1875
            :..:|..||:|.. :....|.:....|.||::.||||        |...|.|:|:..|     |:
 Worm  1012 KRMLLLKKKKYAA-LTINPDTKVEAKELKGLDIVRRDWSQLAKETGTAVVDKILDASL-----TR 1070

  Fly  1876 D--VSKIKAYVCRQFTKLLSGRANLQDLIFAKEF-RGLNGYK--PTACVPALELTRKWMQKDPRH 1935
            |  ||.|...:.....||.||...|:....:|:. |....|.  ...|..|:   .:.:.|..:.
 Worm  1071 DEMVSSIDDLLREIRAKLDSGTVPLEMFQISKQLTRNPEQYADVKAQCHAAV---AQRLNKSGKF 1132

  Fly  1936 VPRRGERVPFIIV---NGPPGMQLIRLVRSPH--DILANEGHKINAIYYITKAIIPPLNRCLLLI 1995
            ..|..:.|.::|.   ...|..|     |:.|  ::..|...||:.:||:.:.|.|.::|
 Worm  1133 NLRHNDIVEYVICEDGTDNPATQ-----RAYHRTEMAENSALKIDLLYYLAQQIHPVVSR----- 1187

  Fly  1996 GANVHDWFASLPRKLLMTPAVGTANELA-----GARGAKSTISQYFSTTSCV------------- 2042
                      |...:..|.||..|..|.     ..|.|.:..||..:...|.
 Worm  1188 ----------LVEPIEETDAVRIAENLGLDSTNYRRAAAAQASQRAAEEDCAWHQENYDLCEGIH 1242

  Fly  2043 ----ID-CGRQTKAGICPDCLKNATTCVVVLSD----------KTARLERGYQLTRQICQ-ACCG 2091
                :| ||.........||:.:|::..::.|.          :..:...|.|:.||:.: ....
 Worm  1243 VICPLDGCGHSNVIRETFDCVTDASSPRLLFSGCAQCQGSWDLQEHQAVIGNQVDRQMSEFVARH 1307

  Fly  2092 RLGSLQCDSLDC 2103
            .|.:.:||...|
 Worm  1308 HLAAFKCDEPTC 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	41/252 (16%)
		POLBc_zeta	1550..2000	CDD:99917	126/481 (26%)
		zf-C4pol	2041..2107	CDD:464119	16/92 (17%)
pola-1	NP_001255109.1	pol2	48..1190	CDD:273159	271/1409 (19%)
		zf-DNA_Pol	1232..1421	CDD:462651	15/88 (17%)