DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and pola-1

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001255109.1	Gene:	pola-1 / 176544	WormBaseID:	WBGene00012936	Length:	1428	Species:	Caenorhabditis elegans

Alignment Length:	1572	Identity:	305/1572 - (19%)
Similarity:	550/1572 - (34%)	Gaps:	474/1572 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 CEIERPHRSEGSALDELKPRRSARHKVNSANPDECSSEIQTTGPRVTTTSLDRPQKKARLSQSPK 799
            |.:.:....|.||:::||..||..   .:..|:....::..|        :|..:.:..:::..|
Worm    19 CGVSQKKSKELSAIEQLKLARSTG---KAYRPELDVEDVYDT--------VDDDEYEKIVAKRQK 72

  Fly   800 ENTKTSMNGTVALEKAT--KDSSSNSESPHQQENSVSEQIEYLESKPKKSDETARSCDEKLQREL 862
            :|.....:|...::...  :|...:..:|...:||.|.:..  |.||||        |:|
Worm    73 DNFIVDDDGMGYVDNGVDFEDDYEDDYAPSSSKNSNSSKKG--EKKPKK--------DKK----- 122

  Fly   863 IPQEPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVTKLRKTPNLKRLRWSIRSELLNKQF 927
                ..|:....|..||::    |..:..::::.:.|..|..:     |::|
Worm   123 ----KGGLHAFLSTTSTKK----PIDESVVKAEFDDDEEVKNM-----LEQL------------- 161

  Fly   928 TPSSGIRPPETETTPQLSPKSNESNTPELMRSFYEHSLIVNSPSVFSDFLDSPEIHMDSPRSAPP 992
                |....|.|..|:.:|    :|..:..|.|                        |||
Worm   162 ----GSSDEEAEEKPKATP----ANPFKRGRKF------------------------DSP----- 189

  Fly   993 SPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVSKVTEVGFLVLHIPGNKLN 1057
               |.|..:||..:........:|     :.|::||:                    |:   |::
Worm   190 ---SGSDSLAPRPIAKKAKREATG-----LAEHKFQR--------------------HV---KVD 223

  Fly  1058 DCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEPAQLAPTWQEA 1122
            :.:.:.  :.:|..:||                      .|.....|::...:| |..||..|
Worm   224 EDEDYG--IPDDYPVAS----------------------PVTSPVKTEKMAEVE-APTAPAIQ-- 261

  Fly  1123 KIWLKAKELLRQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSG---DEDAGEELDC---- 1180
                |.:|.::...|..:..:|..:..::          .|:..|||.   |||...|:..
Worm   262 ----KIEETVKMETEHLEEVEDSLAKFRV----------IEDWTGGSSSQEDEDVKVEVKTGSEA 312

  Fly  1181 ------------SLSLTPLSQAKDKCKA---------TPTSSKARETGKSRLKRGTRLSFIGSQD 1224
                        ::.:..:...:|..||         ..||..|.||....:|...|..:.
Worm   313 FYTMGGEDNTTKAIRMYWIDAYEDVHKANGTVYLFGKVKTSGNAWETCSIVVKNICRKVYF---- 373

  Fly  1225 EEPPSSQSSEQSVSSSAAQAELDRSSFLR--------QLEGSSQDRQHDLSFG------------ 1269
              .|.:::......||.|:...:....||        :.:...::...|.|||
Worm   374 --MPRTKNLSTGEESSLAELHKEIGDVLRNKFNTHEFKCKMVEKELIRDESFGYGCGTKSPLMEV 436

  Fly  1270 ------------LSHATLDNTFG---------------------------------------FKV 1283
                        |...|..|||.                                       |:|
Worm   437 LYPAEKGKLPSDLKGDTFSNTFNTSVTPLERLLIEKKFMGPGWIELYNYSDPKAKTSNCKYEFEV 501

  Fly  1284 NLENLQQAK----ADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYA---IEHSLPDEKLP 1341
            ::|.::..|    :|.....:.::.|.| |:|..| :.|.....|..||..   :.|...|.|..
Worm   502 DMEKMRNIKYLESSDAPPPTIKLLALNV-VTTLND-RKDNEICMISMLFNPKCDLAHPSGDSKDL 564

  Fly  1342 SKACGYIMVNTVQDLLSEGPFHGIDRDIE-----------VQVVTSEAEAFEALLALCERWDADI 1395
            ...|          |:::.|...:..||:           |:.|.:|.......||:....:.|:
Worm   565 KPKC----------LVTKPPGGSLPYDIQKRLETEKLSKFVKSVANEKALLTLFLAMINEDEPDM 619

  Fly  1396 YAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQFTDLDVEMKL-------- 1452
            ..|:::..:               ||.|:||:...|:.::     .:.:.|...:.:
Worm   620 IVGHDLSAT---------------IALLVSRLEKLKLPNW-----SRISRLKRSINIGKIGHSKS 664

  Fly  1453 ------CGRILLD----VWRLMRSEIALTSYTFENVMYHILHKRCPWHTAKSLTEWFGSPCTRWI 1507
                  .||::||    ...|::|.    |:....:...||........|..:.:.:........
Worm   665 GQWELTAGRMMLDSKLAAMELVKSR----SFDLTELSQQILGAERREIYANEIPQLYVDSKDLIS 725

  Fly  1508 VMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLS 1572
            ::.:....:..:|.::.:|:.|....::::::|......:..|...|.|.::|...:..:|:...
Worm   726 LINWSWNDLLLSLRIVVRLNALPLYIQISQIVGGIASRTMMGGRAERNEYLLLHAFEKADLIAPD 790

  Fly  1573 PSVQARAHMRAPEYL--------------ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFS 1623
            ....:.:..:..|..              .|::||:...|...:::|||.|||||:|..||.|::
Worm   791 KYNSSESKKKKEESQEGDEKKSGKAQYSGGLVLEPKKGLYETLILLLDFNSLYPSIIQEYNICYT 855

  Fly  1624 TCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEIL 1688
            |    :|:...|.      .||.|.:..       |:                ||:|||.:.:::
Worm   856 T----LEYSKDSD------EQLSVPQST-------DI----------------EGVLPREIRKLV 887

  Fly  1689 DTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRET 1753
            :.|:.||..||..: :.|.::.:..||:.|||.||..||.....:| |..:..:...|.:||||.
Worm   888 ECRRDVKSLMKSER-NEAKKKQMDIRQMALKLTANSMYGCLGFQYS-RFYAKPLAALVTAKGREI 950

  Fly  1754 LERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVY 1818
            |..:..||   |:....||||||||:.:.....:...|.::|.||.|||.:.: :.::|.|:.|:
Worm   951 LMHSKDLV---EKMGYSVVYGDTDSIMINTNSVDLVAAKKLGNEIKKAVNKCH-RLLELDLDGVF 1011

  Fly  1819 QPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRD--------GCPAVAKMLEKVLRILFETQ 1875
            :..:|..||:|.. :....|.:....|.||::.||||        |...|.|:|:..|     |:
Worm  1012 KRMLLLKKKKYAA-LTINPDTKVEAKELKGLDIVRRDWSQLAKETGTAVVDKILDASL-----TR 1070

  Fly  1876 D--VSKIKAYVCRQFTKLLSGRANLQDLIFAKEF-RGLNGYK--PTACVPALELTRKWMQKDPRH 1935
            |  ||.|...:.....||.||...|:....:|:. |....|.  ...|..|:   .:.:.|..:.
Worm  1071 DEMVSSIDDLLREIRAKLDSGTVPLEMFQISKQLTRNPEQYADVKAQCHAAV---AQRLNKSGKF 1132

  Fly  1936 VPRRGERVPFIIV---NGPPGMQLIRLVRSPH--DILANEGHKINAIYYITKAIIPPLNRCLLLI 1995
            ..|..:.|.::|.   ...|..|     |:.|  ::..|...||:.:||:.:.|.|.::|
Worm  1133 NLRHNDIVEYVICEDGTDNPATQ-----RAYHRTEMAENSALKIDLLYYLAQQIHPVVSR----- 1187

  Fly  1996 GANVHDWFASLPRKLLMTPAVGTANELA-----GARGAKSTISQYFSTTSCV------------- 2042
                      |...:..|.||..|..|.     ..|.|.:..||..:...|.
Worm  1188 ----------LVEPIEETDAVRIAENLGLDSTNYRRAAAAQASQRAAEEDCAWHQENYDLCEGIH 1242

  Fly  2043 ----ID-CGRQTKAGICPDCLKNATTCVVVLSD----------KTARLERGYQLTRQICQ-ACCG 2091
                :| ||.........||:.:|::..::.|.          :..:...|.|:.||:.: ....
Worm  1243 VICPLDGCGHSNVIRETFDCVTDASSPRLLFSGCAQCQGSWDLQEHQAVIGNQVDRQMSEFVARH 1307

  Fly  2092 RLGSLQCDSLDC 2103
            .|.:.:||...|
Worm  1308 HLAAFKCDEPTC 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	41/252 (16%)
		POLBc_zeta	1550..2000	CDD:99917	126/481 (26%)
		zf-C4pol	2041..2107	CDD:405022	16/92 (17%)
pola-1	NP_001255109.1	DNA_pol_alpha_N	33..89	CDD:289058	10/66 (15%)
		pol2	48..1190	CDD:273159	271/1409 (19%)
		DTHCT	154..242	CDD:285332	28/197 (14%)
		DNA_polB_alpha_exo	520..752	CDD:99819	44/267 (16%)
		POLBc_alpha	810..1207	CDD:99915	126/464 (27%)
		zf-DNA_Pol	1232..1421	CDD:286132	15/88 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910