DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-zeta and rev-3

DIOPT Version :9

Sequence 1:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster
Sequence 2:	NP_001299851.1	Gene:	rev-3 / 175809	WormBaseID:	WBGene00021344	Length:	1303	Species:	Caenorhabditis elegans

Alignment Length:	2143	Identity:	471/2143 - (21%)
Similarity:	727/2143 - (33%)	Gaps:	917/2143 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPYD 76
            :.:|..|.:...|.|. .||..|:..|.|    :||..::|.....||.|:|:|||.|||.:...
Worm     3 FCIRNFICEHSQEIPG-PMDTVYNFRRNK----IPVFHIYGVTDTYQKACLHIHGVLPYLVLRVG 62

  Fly    77 KKDFESLERGILQMAMHLDKAI--NISLGQGSSN---AQHVFKIQLVKGIPFYGYHRVEHQFLKI 136
            .|...|:   :..|...::|.|  .|....|.:|   ..:|:|::.......|||...|..|:::
Worm    63 NKVTPSV---LAAMRAKVNKGIEKEIETSTGKTNKFSVDYVYKMESFSSRSLYGYQDEEEDFVRV 124

  Fly   137 YMFNPRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFRR-NHD 200
            |..:|.::::|.:.|....|....|.|:|:|:|:.|||.||.:::||..::  |:.:|||. :.|
Worm   125 YFSSPWYLKKATHSLGKEVIDKPLFQPYEAHLPFHLQFFIDNSIFGMDNIY--LKKVKFRMDSRD 187

  Fly   201 DDV------IPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSNH-TNPGIEA 258
            :|.      :...:::..:||.....||..|. :|.|.....|||   :..::.:.| :|||:|.
Worm   188 EDATLIYKDLSVGDIRNNELLLSPYEKKTTCH-VECDALVTDILN---MEMQADNVHSSNPGLEY 248

  Fly   259 IWNDEKLRRQKLVEKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTALESKLMTLEQS 323
            :|.:||                |:.:|:.: ||             .|:|
Worm   249 LWREEK----------------ERCDALGI-EL-------------KDVF--------------- 268

  Fly   324 TLSEQTLSDQTILPQATMQTTMPGTKAQKRRFNLQKLLANAVYPEECSQDQQQLLVNASFIQNHV 388
                                                   |:..|.:
Worm   269 ---------------------------------------NSYEPRK------------------- 275

  Fly   389 TCGYSSSVSLSTSKDESDDLDETVVDEELILSLTQPHGAIPHDATLREEDLELLDALQLLEEQNE 453

Worm   276 ----------------------------------------------------------------- 275

  Fly   454 SESHVDLDSSLAPLSQHKKFELTPELLDKETAATAALFDEDVDSDEDADQETRHDFSTVLDDVDE 518
                                                                    ||:.
Worm   276 --------------------------------------------------------STIC----- 279

  Fly   519 LLLKLTQSQPAESKELKASSKLPQIDGADDRLQRTPIKSISSKSKSSPSKTPTTPIGQKSLPKSP 583
                     |.|...|:.:.|:
Worm   280 ---------PQERDMLRTARKM------------------------------------------- 292

  Fly   584 RTPKTSAAKKYAPLALTIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPEISLRKKLAMS 648
                   |||:                                               |::..||
Worm   293 -------AKKF-----------------------------------------------RQERCMS 303

  Fly   649 EMRRKSFEDSFVLLKNDCTPVRSTRRSTSNLDKTHIICSLTPRDRNPGLSDMFETEDGKQLPPKK 713
            |    ..:|..|      |.:..::::||::                |.||
Worm   304 E----QLDDLMV------TRIAESQQTTSSV----------------GASD-------------- 328

  Fly   714 VVRKTRWSTRNQDIESLPKAGCEIERPHRSEGSALDELKPRRSARHKVNSANPDECSSEIQTTGP 778
               .|.|                 |:|..      |.::..|..|.|    .|:|..:|.|
Worm   329 ---TTIW-----------------EQPGE------DPMEEDRIGREK----TPEELDAERQ---- 359

  Fly   779 RVTTTSLDRPQKKARLSQSPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLES- 842
                                ||..:         |:|.:|..::   |..||   :|...:.:|
Worm   360 --------------------KEEDR---------EEAAEDDDND---PKNQE---AEMTMFADSQ 389

  Fly   843 KPKKSDETARSCDEKLQRELIPQEPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVTKLRK 907
            ||.:.||....                                   ||.:|.|.|
Worm   390 KPVERDEAMDV-----------------------------------DEEVEDDEE---------- 409

  Fly   908 TPNLKRLRWSIRSELLNKQFTPSSGIRPPETETTPQLSPKSNESNTPELMRSFYEHSLIVNSPSV 972
                                                    .|:..|.|::
Worm   410 ----------------------------------------LNDKGTGEVI--------------- 419

  Fly   973 FSDFLDSPEIHMDSPRSAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSD 1037
                    ||..|.        |.:..::..:....:||:     ..:.:.|:.|......|...
Worm   420 --------EISSDG--------DDDQDIVQWITTKSAYDQ-----NFISMNEFLFDAKKIENQRQ 463

  Fly  1038 VSKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYF 1102
            .|:              ::..|    |::.::
Worm   464 FSR--------------EMTAC----SVMTDE--------------------------------- 477

  Fly  1103 STQQRIAIEPAQLAPTWQEAKIWLKAKELLRQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDG 1167
                                                                  |::..||...
Worm   478 ------------------------------------------------------TVVAAAEHSQ- 487

  Fly  1168 GSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQS 1232
                              |:.|                   :||...|.:.       ||.:|:.
Worm   488 ------------------PVEQ-------------------TRLLSQTSIG-------EPSTSEK 508

  Fly  1233 SEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDC 1297
            |.:|                                                           |.
Worm   509 SVES-----------------------------------------------------------DI 514

  Fly  1298 NHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEGPF 1362
            ..|.:.:||:.|.|:..: ||....||..:..||.:.:       ..|....::.:...|..||.
Worm   515 VGLCVASLELLVDTKMPM-PDAASSEIVSVSLAIYNDV-------CRCSSPKLHVLLTTLPVGPA 571

  Fly  1363 HGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRV 1427
            :...|.:.::   :|.|..|.:.....::|.|:..|||....|||:...|.|.|...|:  :.|.
Worm   572 YSDRRVVHME---TELEMLEEVAKWIVQYDVDVMIGYETIRLSWGFFFRRIKLLGSRIS--MDRA 631

  Fly  1428 PTQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHTA 1492
            ......|.::.|.::.|....:    ||:|:.||:::||::||.:|...:.:.::|.|:.|....
Worm   632 LIDAYEDHIEVDDQEITVAPPK----GRLLVSVWKVVRSDLALRNYDLGSAVANVLRKKIPMLDN 692

  Fly  1493 KSLTEWFGSPCTRWIVMEYYLERVRG-------------------TLTLLDQLDLLGRTSEMAKL 1538
            .:|                 :.|::|                   .::||.:::...:.:|||::
Worm   693 AAL-----------------MRRIKGERSAIRNDVHLHLLKLSSLNISLLTEMNWFLKNAEMARV 740

  Fly  1539 IGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLI 1603
            .||||:||.:||||.|||||:||:|...|.|..|.:...|..|.:||.|.||:||||:.|.||:|
Worm   741 YGIQFHEVWTRGSQLRVESMLLRLAHRMNFVAPSITHLQRNMMGSPEQLQLILEPQSKVYFDPVI 805

  Fly  1604 VLDFQSLYPSMIIAYNYCFSTCLGRVEHL-------GGSSPFEFGASQLRVSRQMLQKLLEHDLV 1661
            |||||||||||:||||||:||.||::.:|       ........||.:...|:..:.||:.:..|
Worm   806 VLDFQSLYPSMVIAYNYCYSTILGKIGNLVQMNDESRNREEIVLGAIKYHPSKDDIVKLVAYKEV 870

  Fly  1662 TVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTY 1726
            ..||...:|||:..|||::|.:|.|||..|.|||.:||..|:.. |:|||.:|||.|||:|||:|
Worm   871 CASPLASMFVKKSKREGVMPLLLREILAARIMVKSAMKRTKNKK-LKRILDARQLALKLVANVSY 934

  Fly  1727 GYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEA 1791
            ||||||:|||||..|:.|:::.||||||||:|::|:..:.....|:|||||||||||.|.:..||
Worm   935 GYTAANWSGRMPCAELADAILGKGRETLERSIEMVQRGDYGGAEVIYGDTDSMFVLVRGASVEEA 999

  Fly  1792 FRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDG 1856
            |.||..|...||..||.||.|||||||:.|:|:|||||.|:|||..:.|..: :||||||||||.
Worm  1000 FEIGRRIVDDVTNSNPDPVVLKLEKVYKGCVLETKKRYAGWMYEHENDEGSL-DAKGIETVRRDT 1063

  Fly  1857 CPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLS-GRANLQDLIFAKEFRGLNGYKPTACVP 1920
            ||.||::|||.|.::|.    ...|.::....|.:|: .:.|....:|.||:||  .|...|.||
Worm  1064 CPIVAEVLEKSLGLIFS----QNWKTFITYLNTVVLNLPQENFSKFVFCKEYRG--DYSARAMVP 1122

  Fly  1921 ALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAII 1985
            ..::....::|.|.|:..||||||::|::|..|..:...|||......|..:|||..||:...|:
Worm  1123 QKKIAEARIRKCPSHITLRGERVPYVIIDGVTGSTVYSCVRSIDQFARNPEYKINTFYYLNAHIL 1187

  Fly  1986 PPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSC-VIDCGRQT 2049
            ..|.|...||           |.|:...|                     |:...| |.||.|..
Worm  1188 AALRRVTDLI-----------PMKIDFLP---------------------FAAEQCFVSDCSRIG 1220

  Fly  2050 KAGICPDCLKNATTCVVVLSDKTARLERGYQLTRQI------CQACCGRLGS---LQCDSLDC 2103
            |...|.:|.:|.....:.|    .:|.|..:...||      ||:...|||.   :.|.:..|
Worm  1221 KTPWCIECEQNPEELALAL----VQLGRESRARSQIIQYCTSCQSSSQRLGEDQVVDCANFTC 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301	54/180 (30%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	50/220 (23%)
		POLBc_zeta	1550..2000	CDD:99917	216/457 (47%)
		zf-C4pol	2041..2107	CDD:405022	21/73 (29%)
rev-3	NP_001299851.1	DnaQ_like_exo	517..725	CDD:299142	51/241 (21%)
		POLBc_zeta	752..1201	CDD:99917	217/467 (46%)
		DNA_pol_B	752..1193	CDD:278562	213/448 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159089
Domainoid	1	1.000	388	1.000	Domainoid score	I420
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3397
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	1	1.000	-	-		oto20175
orthoMCL	1	0.900	-	-		OOG6_102751
Panther	1	1.100	-	-	LDO	PTHR45812
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.700