Protein Alignment PolZ1 and DNApol-alpha180

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: XP_321134.6
• Gene: DNApol-alpha180 / 1281195
• VectorBaseID: AGAMI1_005291
• Length: 1591
• Species: Anopheles gambiae
• Alignment Length: 1565
• Identity: 324/1565 - (20%)
• Similarity: 542/1565 - (34%)
• Gaps: 476/1565 - (30%)

  Fly   767 DECSSEIQTTGPRVTTTSLDRPQKKARLSQSPKENTKTSMNGTVALEKATKDSSSNSESPH---Q 828
            ||...:..|:|.|..:....:.:|:.|      ::...|.:|.|...|:.|:..:..::|.   :
Mosquito    87 DEDELDPLTSGSRSASKKGTKSKKRVR------DDPGHSQSGPVTGRKSLKNYFNREQAPKTKVE 145

  Fly   829 QENSVSEQIEYLESKPKKSDETARSCDEKLQRELIPQEPAG---ISPGDSANSTEEITFSPCHDE 890
            .::::::.:..::|:...:.|...|.:..      |...:|   |.|...|..|     :|...:
Mosquito   146 DDDALADILGEIKSENGGAGEADGSSENG------PGSSSGRKEIRPLQRATKT-----APVKPK 199

  Fly   891 AIESDTESDYIVTKLRKTPNLKR-------LRWSIRSELLNKQFTPS----SGIRPPETETT--- 941
            .:.::.|....:..|.|  ||||       :......|:|......|    :|.:||.|:||
Mosquito   200 ELTAEEEMKRYMANLSK--NLKRSEKKAAVVEEDSDEEMLKNLMAESEGKPAGKKPPATQTTATL 262

  Fly   942 -----PQLSPKSNESNTPELMRSFYEHSLIVNSPSVFSDFLDSPEIHMDS----PRSAPPSPDSN 997
                 ||.:..:..::.|               |::..:.:..||...:.    .::.|||.:..
Mosquito   263 IKQEAPQPAVVAAATSAP---------------PTIKQEPMTQPEPRTEEVKELVKAEPPSQEQL 312

  Fly   998 SFVIAP----------LELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVSKVTEVGFLVLHIP 1052
            ...:..          .|:....::|..|.:|.|..:.|        |::..:         .||
Mosquito   313 GGTVESHFLDDMDDDFAEMANVGEQVEGGPKKADDKKAE--------PAEQEE---------EIP 360

  Fly  1053 GNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEPAQLAP 1117
            .|.||..|...|      |:....::     ||     ...||..|.         |...|:.:.
Mosquito   361 KNLLNAWDSIFS------GIEDGGKK-----GG-----TETGETGVE---------ASGEAECST 400

  Fly  1118 TWQEAKIWL----------KAKELLRQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSGDE 1172
              :..|.|.          :.:..|..|.......|.....:.::.....|.|.|.|....:|..
Mosquito   401 --ETMKFWFWDAWNDPNKCQGELYLFGRISAGNGRDFQSICVHVQNVDRCMYLLARETHTETGAP 463

  Fly  1173 ----DAGEELDCSLSLTPLSQAKDKCKATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSS 1233
                |...|. |:...|.|:..|.:.|.. |.|.|..:..|.|             :.|.:::..
Mosquito   464 VSMLDVYNEF-CNDISTKLNITKYRTKVV-TKSFAYTSATSSL-------------QVPVTAEYL 513

  Fly  1234 EQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVN-------------- 1284
            |...|:..|...||:                      .:.|:.:.||...|
Mosquito   514 EVRYSAKLAAPPLDK----------------------RYRTIAHIFGANTNVVEQFLLERKVKGP 556

  Fly  1285 ----LENL--QQAKA----------DIDC-------------------------------NHLTI 1302
                |.|.  ::.|:          ||.|                               |.:.:
Mosquito   557 CWMELRNTTPRETKSSWCKREVTVPDISCVTLATDAAATVTPPPLVFCSINVRSTLRNNANEIVM 621

  Fly  1303 ITLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLPDEKLPSKACGYIM-VNTV------------- 1353
            ||:  .|:.|..|...|                |:.....:.||... .|||
Mosquito   622 ITM--LVNDRFSLAQPP----------------PNPPFTRQYCGVTRPTNTVWPLNFNPADCKAK 668

  Fly  1354 -------QDLLS--EGPFHGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYV 1409
                   :.|||  ...|..||.|:   |||.::|.|: |..:|:|.       ...:|:.|
Mosquito   669 VTKCESERTLLSWFLSTFQVIDPDL---VVTFDSEDFQ-LDLICQRL-------MTTKMALW--- 719

  Fly  1410 IDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYT 1474
                           ||:...||:.......:.|        ..||::.||.......|...||.
Mosquito   720 ---------------SRIGRLKVKSPASRRVDDF--------FVGRMICDVKTSAEELIRSRSYD 761

  Fly  1475 FENVMYHIL-----HKR--------CPWHTAKSLTEWFGSPCTRWIVME--YYLERVRGTLTLLD 1524
            ...:...:|     .:|        ..:..|.||.:..|      :.|:  :|      ||.|:.
Mosquito   762 LNTLCAEVLKIGEGERRDVLLDEIPAMYEQADSLVQLVG------LTMQDNFY------TLRLMC 814

  Fly  1525 QLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKN-LVPLSPSVQ------------ 1576
            :|:.|....::.::.|......|..|...|.|.::|.....|: ::|.....|
Mosquito   815 ELNALPLALQITQIAGNLMNRTLHGGRAERNEFLLLHAFHEKDYILPDKVGFQAGGGGGGQKNGK 879

  Fly  1577 ------ARAHMRAPEYLA-----LIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVE 1630
                  |.|..|.|:..|     |:::|...||...::::||.|||||:|..||.||:|.|....
Mosquito   880 GGGEEAAAAEKRKPKNKAAYAGGLVLDPIKGFYDKFVLLMDFNSLYPSIIQEYNICFTTVLPPAV 944

  Fly  1631 HLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVK 1695
            ..|...|...|                 |...:.|  .:....|:  |||||.:.:::::|:.||
Mosquito   945 GEGQEGPDPDG-----------------DTALLEP--TILATNEI--GILPRQIRKLVESRRAVK 988

  Fly  1696 QSMKLHKDSSALQRILHSRQLGLKLMANVTY---GYTAANFSGRMPSVEVGDSVVSKGRETLERA 1757
            |.||....|..|....:.||:.|||.||..|   |||.:.|..:    .:...:..||||.|...
Mosquito   989 QLMKASDLSPELAMQYNIRQMALKLTANSLYGCLGYTRSRFYAQ----HLASLITLKGREILMNT 1049

  Fly  1758 IKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCM 1822
            ..:|   |....:|:||||||:.|.....:..:.:|||..|.:.|.:.. :.::|.::.:|:..:
Mosquito  1050 KSIV---ERMNYQVIYGDTDSIMVSTNITDYEQVYRIGASIKQHVNKAY-RCLELDVDGIYKYLL 1110

  Fly  1823 LQTKKRYVGY-MYETADQE-QPVYEAKGIETVRRD--------GCPAVAKML------EKVLRIL 1871
            |..||:|... :.:.||.. ....|.||::.||||        |...:|::|      |::..|.
Mosquito  1111 LLKKKKYAAVSISKKADGAFVCTQELKGLDIVRRDWSRIAVLAGNMILAQILSDAPMDERIENIH 1175

  Fly  1872 FETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEF-RGLNGYKPTACVPALELTRKWMQKDPRH 1935
            ..   :.|:|       ..|::|..:||.|...|:. |.||.|.....:|.:::.:: |.|....
Mosquito  1176 LR---LEKLK-------DDLVAGTLSLQLLEITKQLTRSLNEYGDAGQLPHVQVAQR-MNKQRNR 1229

  Fly  1936 VPRRGERVPFIIVNGPPGMQLIRLVRSPH----------DILANEGHKINAIYYITKAIIP---- 1986
            ..:||:.|.:||..  .|.....:.|:.|          |:|     |::..||:.:.|.|
Mosquito  1230 NYKRGDMVNYIICQ--DGTSAAAMKRAYHIDEIRDPANADLL-----KVDVEYYLAQQIHPVVFR 1287

  Fly  1987 ---PLN-----RCLLLIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSCVI 2043
               ||:     |..|.:|.:        |:| ..|...|      |..|......||....|.:
Mosquito  1288 ICEPLDGTDACRLALCLGLD--------PKK-YRTMVSG------GGGGGGPDGGQYQDGESLI- 1336

  Fly  2044 DCGRQTKAGICPDCLKNATTCVVVLSDKTARLERGYQLT-----RQICQACCGRLGSLQCDSLDC 2103
                :|.|.....|.:...|||.......  :..|::.:     |.:.:.|....|...|.:  .
Mosquito  1337 ----KTAAERYRLCHRFEFTCVACKGKNP--VASGFRPSAGGRHRSVFERCANEEGGAVCTA--A 1393

  Fly  2104 PVLYV 2108
            ||.|:
Mosquito  1394 PVQYL 1398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	51/289 (18%)
		POLBc_zeta	1550..2000	CDD:99917	136/515 (26%)
		zf-C4pol	2041..2107	CDD:464119	13/70 (19%)
DNApol-alpha180	XP_321134.6	None