DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and NADP-ME4

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_178093.1	Gene:	NADP-ME4 / 844314	AraportID:	AT1G79750	Length:	646	Species:	Arabidopsis thaliana

Alignment Length:	647	Identity:	297/647 - (45%)
Similarity:	401/647 - (61%)	Gaps:	27/647 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IALATDLELPKGLPLSLSSRHHWNQLQSSL---------HALHHQQQQQQQQLRSYSSTSETNLE 183
            |:|...|.|.|.:....|:|....|.::.:         .:|...|......|...::||.::||
plant     2 ISLTPSLFLNKTVVPGCSTRLSLRQPRTIITPPASLRVFSSLGSNQDPTGSVLIETTATSSSSLE 66

  Fly   184 DKMSK--PDSKL-----DKYAQRDRLGLWGTGDNEV----VGSLSGFTRLLDKRYSKGLAFTHEE 237
            ...:.  |.|.:     |.|.:..     .|.|..:    :...||:|.|.|..::|||||:|.|
plant    67 TSAADIVPKSTVSGGVQDVYGEDA-----ATEDMPITPWSLSVASGYTLLRDPHHNKGLAFSHRE 126

  Fly   238 RQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLSERNERLFYNVLSSDIAYMMP 302
            |....:.|:||..|.....||:.....|.:....|.|||.::.|.|.||||||.:|...:..::|
plant   127 RDAHYLRGLLPPTVISQDLQVKKIMHTLRQYQVPLQKYMAMMDLQETNERLFYKLLIDHVEELLP 191

  Fly   303 LVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAIVVTDGERILGLGDLGA 367
            ::||||||.|||:|..|....:|:|||:|:||.|::||:||||.:::.||||||||||||||||.
plant   192 VIYTPTVGEACQKYGSIFLRPQGLFISLKEKGKIHEVLRNWPEKNIQVIVVTDGERILGLGDLGC 256

  Fly   368 NGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRERRATGDLYDEFIDEFM 432
            .|||||||||||||||.|::||.|||:|:|||||.|.:|.|..|||||:|||||:.|.|.:.|||
plant   257 QGMGIPVGKLSLYTALGGVRPSACLPVTIDVGTNNEKLLNDEFYIGLRQRRATGEEYSELMHEFM 321

  Fly   433 HACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAVAGLLASLKIKKTQLKD 497
            .|..:.:|:..:||||||||.|||.||:||..:...|||||||||||.:|||:|:|:.....|.|
plant   322 TAVKQNYGEKVVIQFEDFANHNAFDLLAKYGTTHLVFNDDIQGTASVVLAGLIAALRFVGGSLSD 386

  Fly   498 NTLLFLGAGEAALGIANL-CLMAMKVEGLTEEEAKARIWMVDSRGVITRDRPKGGLTEHKLHFAQ 561
            :..||||||||..|||.| .|...|...:..|||:..||:|||:|:|...| |..:...|..:|.
plant   387 HRFLFLGAGEAGTGIAELIALEISKKSHIPLEEARKNIWLVDSKGLIVSSR-KESIQHFKKPWAH 450

  Fly   562 LHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPIIFALSNPTSKAECTAEEAY 626
            .||||..|.:||:.::|.||||.:..|..|.|:::|.||.:||.|||.:||||||::||||||||
plant   451 DHEPIRELVDAVKAIKPTVLIGTSGVGQTFTQDVVETMAKLNEKPIILSLSNPTSQSECTAEEAY 515

  Fly   627 TYTKGRCIFASGSPFAPVTYNNKKFYPGQGNNSYIFPGVALGVLCAGMLNIPEQVFLVAAERLAE 691
            |:::||.|||||||||||.|..|.|.|||.||:|||||..||::.:|.:.:.:.:.|.|:|.|||
plant   516 TWSQGRAIFASGSPFAPVEYEGKTFVPGQANNAYIFPGFGLGLIMSGTIRVHDDMLLAASEALAE 580

  Fly   692 LVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEPVNKLAFIKAQMYDLDY 753
            .:.::...||.:|||..:|...|..||.::...||:.||||..|:|.......::.||...|
plant   581 ELMEEHYEKGMIYPPFRNIRKISARIAAKVAAKAYELGLATRLPQPKELEQCAESSMYSPSY 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	276/542 (51%)
		malic	282..463	CDD:278802	111/180 (62%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	133/277 (48%)
NADP-ME4	NP_178093.1	PLN03129	67..646	CDD:215594	282/582 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	263	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134785
Inparanoid	1	1.050	559	1.000	Inparanoid score	I249
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm1109
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840