DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Men and NADP-ME3

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_197960.1	Gene:	NADP-ME3 / 832657	AraportID:	AT5G25880	Length:	588	Species:	Arabidopsis thaliana

Alignment Length:	599	Identity:	291/599 - (48%)
Similarity:	394/599 - (65%)	Gaps:	39/599 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 TSETNLEDKMSKPDSKLDKYAQRDRLGLWGTGDNEVVGS----------------LSGFTRLLDK 225
            |::|.:.          |:|...:..|: |.|.::|.|.                .||:|.:.|.
plant     3 TNQTQIS----------DEYVTGNSSGV-GGGISDVYGEDSATLDQLVTPWVTSVASGYTLMRDP 56

  Fly   226 RYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQ---DLDKYMYLISLSERNER 287
            ||:||||||.:||....|.|:||.||.  |:.|:. |.::..|.|   .|.:||.|:.|.|||||
plant    57 RYNKGLAFTDKERDAHYITGLLPPVVL--SQDVQE-RKVMHNLRQYTVPLQRYMALMDLQERNER 118

  Fly   288 LFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAIV 352
            |||.:|..::..::|:|||||||.|||:|..|::..:|::||:|:||.|.:||||||:..::.||
plant   119 LFYKLLIDNVEELLPVVYTPTVGEACQKYGSIYRRPQGLYISLKEKGKILEVLKNWPQRGIQVIV 183

  Fly   353 VTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRER 417
            ||||||||||||||..|||||||||||||||.||:||.|||||:|||||.|.:|.:..||||:::
plant   184 VTDGERILGLGDLGCQGMGIPVGKLSLYTALGGIRPSACLPITIDVGTNNEKLLNNEFYIGLKQK 248

  Fly   418 RATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAVA 482
            ||.|:.|.||:.|||.|..:.:|:..|:|||||||.:||.|||||..|...|||||||||||.:|
plant   249 RANGEEYAEFLQEFMCAVKQNYGEKVLVQFEDFANHHAFELLSKYCSSHLVFNDDIQGTASVVLA 313

  Fly   483 GLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVE---GLTEEEAKARIWMVDSRGVIT 544
            ||:|:.|:....|.|:|.||||||||..|||.  |:|:|:.   |...:|.:.:||:|||:|:|.
plant   314 GLIAAQKVLGKSLADHTFLFLGAGEAGTGIAE--LIALKISKETGKPIDETRKKIWLVDSKGLIV 376

  Fly   545 RDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPIIF 609
            .:| |..|...|..:|..|:|:..|..||..::|.||||.:..|..|.:|::|.||.:||.|:|.
plant   377 SER-KESLQHFKQPWAHDHKPVKELLAAVNAIKPTVLIGTSGVGKTFTKEVVEAMATLNEKPLIL 440

  Fly   610 ALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKFYPGQGNNSYIFPGVALGVLCAGM 674
            |||||||:||||||||||:||||.||||||||.||.|:.|||.|||.||.|||||:.||::.:|.
plant   441 ALSNPTSQAECTAEEAYTWTKGRAIFASGSPFDPVQYDGKKFTPGQANNCYIFPGLGLGLIMSGA 505

  Fly   675 LNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEPVN 739
            :.:.:.:.|.|:|.||..|::::.|.|.:|||.::|...|..||..:....|:.|||:..|.|.:
plant   506 IRVRDDMLLAASEALASQVTEENFANGLIYPPFANIRKISANIAASVGAKTYELGLASNLPRPKD 570

  Fly   740 KLAFIKAQMYDLDY 753
            .:...::.||...|
plant   571 LVKMAESCMYSPVY 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	283/563 (50%)
		malic	282..463	CDD:278802	111/180 (62%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	133/279 (48%)
NADP-ME3	NP_197960.1	PLN03129	20..588	CDD:215594	286/572 (50%)
		malic	113..293	CDD:278802	110/179 (61%)
		NAD_bind_1_malic_enz	304..582	CDD:133454	134/280 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	263	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I249
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm1109
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840